{"id":6687,"date":"2024-11-04T15:45:15","date_gmt":"2024-11-04T21:45:15","guid":{"rendered":"https:\/\/shockwavemedical.com\/clinical-evidence\/disrupt-btk-ii\/"},"modified":"2026-02-17T15:48:28","modified_gmt":"2026-02-17T21:48:28","slug":"btk-ii","status":"publish","type":"clinical-evidence","link":"https:\/\/shockwavemedical.com\/de\/clinical-evidence\/btk-ii\/","title":{"rendered":"DISRUPT BTK II"},"content":{"rendered":"\n\n\n<section id=\"block_60e4e901c2b92db47fae460578e39dff\" class=\"block block--primary-header u-darkMode u-bgColor_primary\"\n\tstyle=\"--desktop-bg-image: url('https:\/\/shockwavemedical.com\/wp-content\/uploads\/2024\/11\/Background-Pulses.png');\n\t\t\t\t --mobile-bg-image: url('');\">\n\n\t<div class=\"primary-header-container text_colors\">\n\n\t\t<!-- Heading -->\n\t\t<div class=\"heading\">\n\t\t\t<h1 class=\"main-heading\">DISRUPT BTK II<\/h1>\n\t\t\t<h3 class=\"sub-heading\">Count on it: New data confirms Shockwave Intravascular Lithotripsy\u2019s (IVL) impact below the knee (BTK): Acute, 30-day, 6-month and 12-month outcomes in the global prospective, multi-center, single-arm IVL study assessing the safety and effectiveness of the Shockwave peripheral IVL system for the treatment of calcified, stenotic BTK lesions. <\/h3>\n\t\t<\/div>\n\n\t\t<!-- Optional links -->\n\t\t\n\t\t<!-- links - J&J -->\n\t\t\n\t\t<!-- Social share -->\n\t\t\t\t<!-- Foreground for Desktop -->\n\t\t\t\t\t<div class=\"desktop-foreground-file\">\n\t\t\t\t\t\t\t\t\t<img decoding=\"async\" data-src=\"https:\/\/shockwavemedical.com\/wp-content\/uploads\/2024\/11\/DISRUPT-BTK-II-clinical-hero-image-3.png\" alt=\"DISRUPT BTK II logo\" role=\"img\" aria-label=\"Foreground image for desktop\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" class=\"lazyload\" style=\"--smush-placeholder-width: 955px; --smush-placeholder-aspect-ratio: 955\/970;\">\n\t\t\t\t\t\t\t<\/div>\n\t\t\n\t\t<!-- Foreground for Mobile -->\n\t\t\t\t\t<div class=\"mobile-foreground-file\">\n\t\t\t\t\t\t\t\t\t<img decoding=\"async\" data-src=\"https:\/\/shockwavemedical.com\/wp-content\/uploads\/2024\/11\/Clinical-Hero-Images-mobile-08.png\" alt=\"DISRUPT BTK II logo\" role=\"img\" aria-label=\"Foreground image for mobile\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" class=\"lazyload\" style=\"--smush-placeholder-width: 814px; --smush-placeholder-aspect-ratio: 814\/416;\">\n\t\t\t\t\t\t\t<\/div>\n\t\t\t<\/div>\n<\/section>\n\n\n<section id=\"block_e6e2046efb25c696fc233d419fab2211\" class=\"block block--content-3-or-4-up text_colors \" aria-labelledby=\"section-heading-block_e6e2046efb25c696fc233d419fab2211\">\n\t<div class=\"container\">\n\n\t\t<!-- Header -->\n\t\t\t\t\t<header class=\"heading-row\">\n\t\t\t\t\t\t\t\t\t<h2 id=\"section-heading-block_e6e2046efb25c696fc233d419fab2211\" class=\"optional-heading\">\n\t\t\t\t\t\tFull Cohort Key Findings \t\t\t\t\t<\/h2>\n\t\t\t\t\n\t\t\t\t\t\t\t<\/header>\n\t\t\n\t\t<!-- Cards Section -->\n\t\t<ul class=\"cards three-cards\" role=\"list\">\n\t\t\t\t\t\t\t<li class=\"card content-3-or-4-up-card three-cards\" role=\"listitem\">\n\t\t\t\t\t\n\t\t\t\t\t<!-- Card Content -->\n\t\t\t\t\t<div class=\"card-heading-description-link\">\n\t\t\t\t\t\t<h3 class=\"card-heading\">Limb Preservation <\/h3>\n\n\t\t\t\t\t\t<div class=\"card-description-link\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"card-description small_body\">The 12-month outcomes confirm the durability of IVL in complex BTK anatomy through sustained vessel patency and low reintervention rates which lead to limb preservation and ongoing symptom relief.  <\/div>\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/li>\n\t\t\t\t\t\t\t<li class=\"card content-3-or-4-up-card three-cards\" role=\"listitem\">\n\t\t\t\t\t\n\t\t\t\t\t<!-- Card Content -->\n\t\t\t\t\t<div class=\"card-heading-description-link\">\n\t\t\t\t\t\t<h3 class=\"card-heading\">Safety & Effectiveness <\/h3>\n\n\t\t\t\t\t\t<div class=\"card-description-link\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"card-description small_body\">At 12 months, IVL continues to demonstrate a strong safety profile and consistent effectiveness in high-risk patients with challenging calcium BTK. <\/div>\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/li>\n\t\t\t\t\t\t\t<li class=\"card content-3-or-4-up-card three-cards\" role=\"listitem\">\n\t\t\t\t\t\n\t\t\t\t\t<!-- Card Content -->\n\t\t\t\t\t<div class=\"card-heading-description-link\">\n\t\t\t\t\t\t<h3 class=\"card-heading\">Frontline BTK Strategy <\/h3>\n\n\t\t\t\t\t\t<div class=\"card-description-link\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"card-description small_body\">The DISRUPT BTK II 12-month data establishes IVL as a frontline calcium modification strategy* for complex BTK lesions, delivering outcomes that redefine the benchmark for success in the treatment of patients with chronic limb-threatening ischemia (CLTI). <\/div>\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/li>\n\t\t\t\t\t<\/ul>\n\t<\/div>\n<\/section>\n\n\n<section id=\"block_60d81cf2cf4c29f6cad644119182084a\" class=\"block block--wysiwyg wysiwyg_styles u-bgColorNone container\">\n\t<div class=\"u-wysiwyg u-animation\">\n\t\t<p><span class=\"legal_copy\">*Frontline Strategy: The approach of utilizing IVL as the primary treatment method, implemented without the use of atherectomy. This strategy is backed by the BTK II data based on the percentage of procedures involving pre-dilatation and post-dilatation, as well as the proportion of stenting performed. Our BTK II data indicates a notably low usage of both pre-dilatation and post-stenting in these cases.<br \/>\n<\/span><span class=\"legal_copy\">Armstrong E, VIVA 2025<\/span><\/p>\n\t<\/div>\n\t<\/section>\n\n<section\n\tid=\"block_41d3bcb93e9334b463a2405c965d7ded\"\n\tclass=\"block block--spacer-with-optional-divider \"\n\taria-label=\"Spacer section with optional divider\">\n\t<div class=\"spacer-with-optional-divider-container container\">\n\n\t\t<!-- Space Above -->\n\t\t<div\n\t\t\tclass=\"space-above\"\n\t\t\tstyle=\"--aboveDesktop: 60px; --aboveMobile: 30px;\"\n\t\t\taria-hidden=\"true\"\n\t\t\trole=\"presentation\">\n\t\t<\/div>\n\n\t\t<!-- Optional Divider -->\n\t\t\n\t\t<!-- Space Below -->\n\t\t<div\n\t\t\tclass=\"space-below\"\n\t\t\tstyle=\"--belowDesktop: 0px; --belowMobile: 0px;\"\n\t\t\taria-hidden=\"true\"\n\t\t\trole=\"presentation\">\n\t\t<\/div>\n\n\t<\/div>\n<\/section>\n\n\n<section id=\"block_c19444fb04e3b9b6469600e0098da6ee\" class=\"block block--attribution \" role=\"region\" aria-labelledby=\"block_c19444fb04e3b9b6469600e0098da6ee-heading\" aria-describedby=\"block_c19444fb04e3b9b6469600e0098da6ee-desc\">\n\t<div class=\"container\">\n\t\t<div class=\"container-inner\">\n\t\t\t\t\t\t\t<h3 id=\"block_c19444fb04e3b9b6469600e0098da6ee-heading\" class=\"heading\">\n\t\t\t\t\tStudy Leadership \t\t\t\t<\/h3>\n\t\t\t\t\t\t<p id=\"block_c19444fb04e3b9b6469600e0098da6ee-desc\" class=\"sr-only\">This section contains attributions including profile pictures, titles, descriptions, and Twitter handles.<\/p>\n\n\t\t\t\t\t\t\t<ul class=\"attributions-container\" role=\"list\">\n\t\t\t\t\t\t\t\t\t\t\t<li class=\"attribution\" role=\"listitem\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"details\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"title\">Venita Chandra, MD <\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"description\">Clinical Associate Professor of Surgery, Associate Program Director \u2013 Vascular Surgery, Medical Director \r\nStanford Advanced Wound Center <\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t\t\t\t<li class=\"attribution\" role=\"listitem\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"details\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"title\">Ehrin Armstrong, MD <\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"description\">Medical Director, Aurora Denver Cardiology Associates, Swedish Medical Center<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t\t<\/ul>\n\t\t\t\t\t<\/div>\n\t<\/div>\n<\/section>\n\n\n<section id=\"design\" class=\"block block--study-design-patient-chars \" role=\"region\" aria-labelledby=\"design-heading\">\n\t<div class=\"container\">\n\t\t\t\t\t<div class=\"heading-row wysiwyg_styles\">\n\t\t\t\t\t\t\t\t\t<h2 id=\"design-heading\" class=\"heading\">\n\t\t\t\t\t\tDISRUPT BTK II Study Design\t\t\t\t\t<\/h2>\n\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"columns wysiwyg_styles\" aria-label=\"Study Design Columns\">\n\t\t\t<div class=\"columns-2-and-3\">\n\t\t\t\t<div class=\"column-2\">\n\t\t\t\t\t<p><b><span data-contrast=\"auto\">Objective<\/span><\/b><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">Assess the continued safety and effectiveness of the Shockwave Medical peripheral IVL system for the treatment of calcified, stenotic lesions in BTK arteries. Products included Shockwave M5+ and Shockwave S4<\/span><\/p>\n<p><strong>Key Inclusion Criteria<\/strong><\/p>\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"5\" data-list-defn-props=\"{\"335552541\":1,\"335559685\":360,\"335559991\":360,\"469769226\":\"Symbol\",\"469769242\":[8226],\"469777803\":\"left\",\"469777804\":\"\uf0b7\",\"469777815\":\"hybridMultilevel\"}\" aria-setsize=\"-1\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"auto\">Rutherford classification (RC) 3-5, RC 3 capped at 20% of enrolled patients<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"5\" data-list-defn-props=\"{\"335552541\":1,\"335559685\":360,\"335559991\":360,\"469769226\":\"Symbol\",\"469769242\":[8226],\"469777803\":\"left\",\"469777804\":\"\uf0b7\",\"469777815\":\"hybridMultilevel\"}\" aria-setsize=\"-1\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"auto\">Moderate-severe calcification*<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"5\" data-list-defn-props=\"{\"335552541\":1,\"335559685\":360,\"335559991\":360,\"469769226\":\"Symbol\",\"469769242\":[8226],\"469777803\":\"left\",\"469777804\":\"\uf0b7\",\"469777815\":\"hybridMultilevel\"}\" aria-setsize=\"-1\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"auto\">Up to two BTK lesions \u2264 200 mm in length<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/li>\n<\/ul>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"column-3\">\n\t\t\t\t\t<p><b><span data-contrast=\"auto\">Primary Safety Endpoint<\/span><\/b><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">Major adverse limb events (MALE) or post-operative death (POD) at 30-days<\/span><\/p>\n<p><b><span data-contrast=\"auto\">Primary Effectiveness Endpoint<\/span><\/b><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">Procedural success, defined as <\/span><b><span data-contrast=\"auto\">\u2264 50%<\/span><\/b><span data-contrast=\"auto\"> residual stenosis for all treated target lesions without serious angiographic complications<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">Additional analysis to include lesions with <\/span><b><span data-contrast=\"auto\">\u2264 30%<\/span><\/b><span data-contrast=\"auto\"> residual stenosis without angiographic complications<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<p>Independent Clinical Events Committee (CEC), Angiographic Core Laboratory, and Duplex Ultrasound Core Laboratory<\/p>\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t<div class=\"column-1\">\n\t\t\t\t<div class=\"column-1-content\">\n\t\t\t\t\t<div class=\"column-1-content-top\">\n\t\t\t\t\t\tStudy cohort represents complex patients with challenging calcified lesions below the knee\t\t\t\t\t<\/div>\n\t\t\t\t\t<div class=\"column-1-content-bottom\">\n\t\t\t\t\t\tResults validate Shockwave IVL as a safe and effective treatment for challenging calcific below-the-knee lesions with minimal need for provisional stenting\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"column-1-arrow\" aria-hidden=\"true\" aria-label=\"Arrow pointing downwards to indicate result\"><i class=\"fa-regular fa-arrow-down\"><\/i><\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t<\/div>\n<\/section>\n\n\n<section id=\"block_e265d8a78a758886b0bfc985bfe78712\" class=\"block block--wysiwyg wysiwyg_styles u-bgColorNone container\">\n\t<div class=\"u-wysiwyg u-animation\">\n\t\t<p><span class=\"legal_copy\">* Presence of fluoroscopic evidence of calcification by PARC (Peripheral Academic Research Consortium) definition: 1) on parallel sides of the vessel and 2) extending > 50% the length of the lesion if lesion is \u2265 50 mm in length; or extending for minimum of 20 mm if lesion is < 50 mm in length.\u00a0<\/span><\/p>\n\t<\/div>\n\t<\/section>\n\n<section\n\tid=\"block_41d3bcb93e9334b463a2405c965d7ded\"\n\tclass=\"block block--spacer-with-optional-divider \"\n\taria-label=\"Spacer section with optional divider\">\n\t<div class=\"spacer-with-optional-divider-container container\">\n\n\t\t<!-- Space Above -->\n\t\t<div\n\t\t\tclass=\"space-above\"\n\t\t\tstyle=\"--aboveDesktop: 60px; --aboveMobile: 30px;\"\n\t\t\taria-hidden=\"true\"\n\t\t\trole=\"presentation\">\n\t\t<\/div>\n\n\t\t<!-- Optional Divider -->\n\t\t\n\t\t<!-- Space Below -->\n\t\t<div\n\t\t\tclass=\"space-below\"\n\t\t\tstyle=\"--belowDesktop: 0px; --belowMobile: 0px;\"\n\t\t\taria-hidden=\"true\"\n\t\t\trole=\"presentation\">\n\t\t<\/div>\n\n\t<\/div>\n<\/section>\n\n<section id=\"block_367395188e24ba4058a03aae43e997e0\" class=\"block block--featured-clinical-evidence \" aria-labelledby=\"featured-clinical-evidence-title\">\n\t\t\t<div class=\"featured-clinical-evidence--top text_colors has-stat-callout on-dark\">\n\t\t\t<div class=\"featured-clinical-evidence--title\">\n\t\t\t\t\t\t\t\t\t<h2 id=\"featured-clinical-evidence-title\" class=\"heading\">By the Numbers<\/h2>\n\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\n\t\t\t\n\t\t\t\n<section id=\"block_367395188e24ba4058a03aae43e997e0\" class=\"block block--stat-callout \" role=\"region\" aria-labelledby=\"statCalloutTitle\" aria-describedby=\"statCalloutDesc\">\n\t<h2 id=\"statCalloutTitle\" class=\"sr-only\">Statistics Callout<\/h2> <!-- Add a hidden heading for accessibility -->\n\t<p id=\"statCalloutDesc\" class=\"sr-only\">This section presents key statistical information with numbers and descriptions.<\/p> <!-- Hidden description -->\n\n\t<!-- Changing container to ul for better semantics -->\n\t<ul class=\"container\" role=\"list\">\n\t\t\t\t\t\t<!-- Each card is now an li element for semantic correctness -->\n\t\t\t<li class=\"card\" id=\"block_367395188e24ba4058a03aae43e997e0-card-0\" role=\"listitem\" aria-labelledby=\"block_367395188e24ba4058a03aae43e997e0-card-0-number\" aria-describedby=\"block_367395188e24ba4058a03aae43e997e0-card-0-description\">\n\t\t\t\t<div class=\"card-top\">\n\t\t\t\t\t\t\t\t\t\t\t<div class=\"card-number\" id=\"block_367395188e24ba4058a03aae43e997e0-card-0-number\">250<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"card-symbol\">\n\t\t\t\t\t\t\t<span><\/span>\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t\t\t<div class=\"card-description font--p\" id=\"block_367395188e24ba4058a03aae43e997e0-card-0-description\">\n\t\t\t\t\t\tPatients\t\t\t\t\t<\/div>\n\t\t\t\t\n\t\t\t<\/li>\n\t\t\t\t\t<!-- Each card is now an li element for semantic correctness -->\n\t\t\t<li class=\"card\" id=\"block_367395188e24ba4058a03aae43e997e0-card-1\" role=\"listitem\" aria-labelledby=\"block_367395188e24ba4058a03aae43e997e0-card-1-number\" aria-describedby=\"block_367395188e24ba4058a03aae43e997e0-card-1-description\">\n\t\t\t\t<div class=\"card-top\">\n\t\t\t\t\t\t\t\t\t\t\t<div class=\"card-number\" id=\"block_367395188e24ba4058a03aae43e997e0-card-1-number\">305<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"card-symbol\">\n\t\t\t\t\t\t\t<span><\/span>\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t\t\t<div class=\"card-description font--p\" id=\"block_367395188e24ba4058a03aae43e997e0-card-1-description\">\n\t\t\t\t\t\tLesions\t\t\t\t\t<\/div>\n\t\t\t\t\n\t\t\t<\/li>\n\t\t\t\t\t<!-- Each card is now an li element for semantic correctness -->\n\t\t\t<li class=\"card\" id=\"block_367395188e24ba4058a03aae43e997e0-card-2\" role=\"listitem\" aria-labelledby=\"block_367395188e24ba4058a03aae43e997e0-card-2-number\" aria-describedby=\"block_367395188e24ba4058a03aae43e997e0-card-2-description\">\n\t\t\t\t<div class=\"card-top\">\n\t\t\t\t\t\t\t\t\t\t\t<div class=\"card-number\" id=\"block_367395188e24ba4058a03aae43e997e0-card-2-number\">38<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"card-symbol\">\n\t\t\t\t\t\t\t<span><\/span>\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t\t\t<div class=\"card-description font--p\" id=\"block_367395188e24ba4058a03aae43e997e0-card-2-description\">\n\t\t\t\t\t\tGlobal sites\t\t\t\t\t<\/div>\n\t\t\t\t\n\t\t\t<\/li>\n\t\t\t\t\t<!-- Each card is now an li element for semantic correctness -->\n\t\t\t<li class=\"card\" id=\"block_367395188e24ba4058a03aae43e997e0-card-3\" role=\"listitem\" aria-labelledby=\"block_367395188e24ba4058a03aae43e997e0-card-3-number\" aria-describedby=\"block_367395188e24ba4058a03aae43e997e0-card-3-description\">\n\t\t\t\t<div class=\"card-top\">\n\t\t\t\t\t\t\t\t\t\t\t<div class=\"card-number\" id=\"block_367395188e24ba4058a03aae43e997e0-card-3-number\">2<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"card-symbol\">\n\t\t\t\t\t\t\t<span><\/span>\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t\t\t<div class=\"card-description font--p\" id=\"block_367395188e24ba4058a03aae43e997e0-card-3-description\">\n\t\t\t\t\t\tYear follow-up\t\t\t\t\t<\/div>\n\t\t\t\t\n\t\t\t<\/li>\n\t\t\t\t<\/ul>\n<\/section>\t\t<\/div>\n\t\t<ul class=\"featured-clinical-evidence-list text_colors\" role=\"list\">\n\t\t\t<\/ul>\n<\/section>\n\n\n<section\n\tid=\"block_41d3bcb93e9334b463a2405c965d7ded\"\n\tclass=\"block block--spacer-with-optional-divider \"\n\taria-label=\"Spacer section with optional divider\">\n\t<div class=\"spacer-with-optional-divider-container container\">\n\n\t\t<!-- Space Above -->\n\t\t<div\n\t\t\tclass=\"space-above\"\n\t\t\tstyle=\"--aboveDesktop: 60px; --aboveMobile: 30px;\"\n\t\t\taria-hidden=\"true\"\n\t\t\trole=\"presentation\">\n\t\t<\/div>\n\n\t\t<!-- Optional Divider -->\n\t\t\n\t\t<!-- Space Below -->\n\t\t<div\n\t\t\tclass=\"space-below\"\n\t\t\tstyle=\"--belowDesktop: 0px; --belowMobile: 0px;\"\n\t\t\taria-hidden=\"true\"\n\t\t\trole=\"presentation\">\n\t\t<\/div>\n\n\t<\/div>\n<\/section>\n\n\n<section id=\"block_0b66ecedd6ed49996e946fa58df7374d\" class=\"block block--wysiwyg wysiwyg_styles u-bgColorNone container\">\n\t<div class=\"u-wysiwyg u-animation\">\n\t\t<h2>Full Cohort Baseline Demographics<\/h2>\n<p>The DISRUPT BTK II study enrolled the largest cohort of real-world, complex patients* with moderate to severe calcium below the knee; no other technology has been evaluated in such severely calcified BTK lesions to date. BTK II sets a new benchmark for what\u2019s possible for these challenging lesions.<\/p>\n<p><span class=\"legal_copy\">*The majority of patients enrolled had CLTI, thus a majority of the comorbidities are attributed to this population.<\/span><\/p>\n<h3><span class=\"TextRun SCXW250675636 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW250675636 BCX0\">Medical History<\/span><\/span><span class=\"EOP SCXW250675636 BCX0\" data-ccp-props=\"{}\">\u00a0<\/span><\/h3>\n\t<\/div>\n\t<\/section>\n\n\n<section id=\"block_13a06e25e42695c9881ca225366a7fb7\" class=\"block block--stat-callout \" role=\"region\" aria-labelledby=\"statCalloutTitle\" aria-describedby=\"statCalloutDesc\">\n\t<h2 id=\"statCalloutTitle\" class=\"sr-only\">Statistics Callout<\/h2> <!-- Add a hidden heading for accessibility -->\n\t<p id=\"statCalloutDesc\" class=\"sr-only\">This section presents key statistical information with numbers and descriptions.<\/p> <!-- Hidden description -->\n\n\t<!-- Changing container to ul for better semantics -->\n\t<ul class=\"container\" role=\"list\">\n\t\t\t\t\t\t<!-- Each card is now an li element for semantic correctness -->\n\t\t\t<li class=\"card\" id=\"block_13a06e25e42695c9881ca225366a7fb7-card-0\" role=\"listitem\" aria-labelledby=\"block_13a06e25e42695c9881ca225366a7fb7-card-0-number\" aria-describedby=\"block_13a06e25e42695c9881ca225366a7fb7-card-0-description\">\n\t\t\t\t<div class=\"card-top\">\n\t\t\t\t\t\t\t\t\t\t\t<div class=\"card-number\" id=\"block_13a06e25e42695c9881ca225366a7fb7-card-0-number\">58.5<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"card-symbol\">\n\t\t\t\t\t\t\t<span>%<\/span>\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t\t\t<div class=\"card-description font--p\" id=\"block_13a06e25e42695c9881ca225366a7fb7-card-0-description\">\n\t\t\t\t\t\tPatients had wounds at baseline\t\t\t\t\t<\/div>\n\t\t\t\t\n\t\t\t<\/li>\n\t\t\t\t\t<!-- Each card is now an li element for semantic correctness -->\n\t\t\t<li class=\"card\" id=\"block_13a06e25e42695c9881ca225366a7fb7-card-1\" role=\"listitem\" aria-labelledby=\"block_13a06e25e42695c9881ca225366a7fb7-card-1-number\" aria-describedby=\"block_13a06e25e42695c9881ca225366a7fb7-card-1-description\">\n\t\t\t\t<div class=\"card-top\">\n\t\t\t\t\t\t\t\t\t\t\t<div class=\"card-number\" id=\"block_13a06e25e42695c9881ca225366a7fb7-card-1-number\">15<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"card-symbol\">\n\t\t\t\t\t\t\t<span>%<\/span>\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t\t\t<div class=\"card-description font--p\" id=\"block_13a06e25e42695c9881ca225366a7fb7-card-1-description\">\n\t\t\t\t\t\tHemodialysis-dependent\t\t\t\t\t<\/div>\n\t\t\t\t\n\t\t\t<\/li>\n\t\t\t\t\t<!-- Each card is now an li element for semantic correctness -->\n\t\t\t<li class=\"card\" id=\"block_13a06e25e42695c9881ca225366a7fb7-card-2\" role=\"listitem\" aria-labelledby=\"block_13a06e25e42695c9881ca225366a7fb7-card-2-number\" aria-describedby=\"block_13a06e25e42695c9881ca225366a7fb7-card-2-description\">\n\t\t\t\t<div class=\"card-top\">\n\t\t\t\t\t\t\t\t\t\t\t<div class=\"card-number\" id=\"block_13a06e25e42695c9881ca225366a7fb7-card-2-number\">70<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"card-symbol\">\n\t\t\t\t\t\t\t<span>%<\/span>\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t\t\t<div class=\"card-description font--p\" id=\"block_13a06e25e42695c9881ca225366a7fb7-card-2-description\">\n\t\t\t\t\t\tDiabetes mellitus\t\t\t\t\t<\/div>\n\t\t\t\t\n\t\t\t<\/li>\n\t\t\t\t<\/ul>\n<\/section>\n\n<section\n\tid=\"block_358ba80a1d69d18b6a85a8b6bca2c48b\"\n\tclass=\"block block--spacer-with-optional-divider \"\n\taria-label=\"Spacer section with optional divider\">\n\t<div class=\"spacer-with-optional-divider-container container\">\n\n\t\t<!-- Space Above -->\n\t\t<div\n\t\t\tclass=\"space-above\"\n\t\t\tstyle=\"--aboveDesktop: 30px; --aboveMobile: 20px;\"\n\t\t\taria-hidden=\"true\"\n\t\t\trole=\"presentation\">\n\t\t<\/div>\n\n\t\t<!-- Optional Divider -->\n\t\t\n\t\t<!-- Space Below -->\n\t\t<div\n\t\t\tclass=\"space-below\"\n\t\t\tstyle=\"--belowDesktop: 0px; --belowMobile: 0px;\"\n\t\t\taria-hidden=\"true\"\n\t\t\trole=\"presentation\">\n\t\t<\/div>\n\n\t<\/div>\n<\/section>\n\n\n<section id=\"block_aebed64cd2afacc09562559c07f41c9a\" class=\"block block--wysiwyg wysiwyg_styles u-bgColorNone container\">\n\t<div class=\"u-wysiwyg u-animation\">\n\t\t<h3><span class=\"TextRun SCXW167493589 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW167493589 BCX0\">Rutherford Category<\/span><\/span><span class=\"EOP SCXW167493589 BCX0\" data-ccp-props=\"{}\">\u00a0<\/span><\/h3>\n\t<\/div>\n\t<\/section>\n\n\n<section id=\"block_bb151349352246c792b88c473cf1d91a\" class=\"block block--stat-callout \" role=\"region\" aria-labelledby=\"statCalloutTitle\" aria-describedby=\"statCalloutDesc\">\n\t<h2 id=\"statCalloutTitle\" class=\"sr-only\">Statistics Callout<\/h2> <!-- Add a hidden heading for accessibility -->\n\t<p id=\"statCalloutDesc\" class=\"sr-only\">This section presents key statistical information with numbers and descriptions.<\/p> <!-- Hidden description -->\n\n\t<!-- Changing container to ul for better semantics -->\n\t<ul class=\"container\" role=\"list\">\n\t\t\t\t\t\t<!-- Each card is now an li element for semantic correctness -->\n\t\t\t<li class=\"card\" id=\"block_bb151349352246c792b88c473cf1d91a-card-0\" role=\"listitem\" aria-labelledby=\"block_bb151349352246c792b88c473cf1d91a-card-0-number\" aria-describedby=\"block_bb151349352246c792b88c473cf1d91a-card-0-description\">\n\t\t\t\t<div class=\"card-top\">\n\t\t\t\t\t\t\t\t\t\t\t<div class=\"card-number\" id=\"block_bb151349352246c792b88c473cf1d91a-card-0-number\">57<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"card-symbol\">\n\t\t\t\t\t\t\t<span>%<\/span>\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t\t\t<div class=\"card-description font--p\" id=\"block_bb151349352246c792b88c473cf1d91a-card-0-description\">\n\t\t\t\t\t\tRC 5, minor tissue loss, CLTI\t\t\t\t\t<\/div>\n\t\t\t\t\n\t\t\t<\/li>\n\t\t\t\t\t<!-- Each card is now an li element for semantic correctness -->\n\t\t\t<li class=\"card\" id=\"block_bb151349352246c792b88c473cf1d91a-card-1\" role=\"listitem\" aria-labelledby=\"block_bb151349352246c792b88c473cf1d91a-card-1-number\" aria-describedby=\"block_bb151349352246c792b88c473cf1d91a-card-1-description\">\n\t\t\t\t<div class=\"card-top\">\n\t\t\t\t\t\t\t\t\t\t\t<div class=\"card-number\" id=\"block_bb151349352246c792b88c473cf1d91a-card-1-number\">23<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"card-symbol\">\n\t\t\t\t\t\t\t<span>%<\/span>\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t\t\t<div class=\"card-description font--p\" id=\"block_bb151349352246c792b88c473cf1d91a-card-1-description\">\n\t\t\t\t\t\tRC 4, ischemic rest pain, CLTI\t\t\t\t\t<\/div>\n\t\t\t\t\n\t\t\t<\/li>\n\t\t\t\t\t<!-- Each card is now an li element for semantic correctness -->\n\t\t\t<li class=\"card\" id=\"block_bb151349352246c792b88c473cf1d91a-card-2\" role=\"listitem\" aria-labelledby=\"block_bb151349352246c792b88c473cf1d91a-card-2-number\" aria-describedby=\"block_bb151349352246c792b88c473cf1d91a-card-2-description\">\n\t\t\t\t<div class=\"card-top\">\n\t\t\t\t\t\t\t\t\t\t\t<div class=\"card-number\" id=\"block_bb151349352246c792b88c473cf1d91a-card-2-number\">20<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"card-symbol\">\n\t\t\t\t\t\t\t<span>%<\/span>\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t\t\t<div class=\"card-description font--p\" id=\"block_bb151349352246c792b88c473cf1d91a-card-2-description\">\n\t\t\t\t\t\tRC 3, severe claudication*\t\t\t\t\t<\/div>\n\t\t\t\t\n\t\t\t<\/li>\n\t\t\t\t<\/ul>\n<\/section>\n\n<section\n\tid=\"block_358ba80a1d69d18b6a85a8b6bca2c48b\"\n\tclass=\"block block--spacer-with-optional-divider \"\n\taria-label=\"Spacer section with optional divider\">\n\t<div class=\"spacer-with-optional-divider-container container\">\n\n\t\t<!-- Space Above -->\n\t\t<div\n\t\t\tclass=\"space-above\"\n\t\t\tstyle=\"--aboveDesktop: 30px; --aboveMobile: 20px;\"\n\t\t\taria-hidden=\"true\"\n\t\t\trole=\"presentation\">\n\t\t<\/div>\n\n\t\t<!-- Optional Divider -->\n\t\t\n\t\t<!-- Space Below -->\n\t\t<div\n\t\t\tclass=\"space-below\"\n\t\t\tstyle=\"--belowDesktop: 0px; --belowMobile: 0px;\"\n\t\t\taria-hidden=\"true\"\n\t\t\trole=\"presentation\">\n\t\t<\/div>\n\n\t<\/div>\n<\/section>\n\n\n<section id=\"block_5ee6e741a59ac71edd8623011ae871fb\" class=\"block block--wysiwyg wysiwyg_styles u-bgColorNone container\">\n\t<div class=\"u-wysiwyg u-animation\">\n\t\t<h3><span class=\"TextRun SCXW223266547 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW223266547 BCX0\">Lesions<\/span><\/span><span class=\"EOP SCXW223266547 BCX0\" data-ccp-props=\"{}\">\u00a0<\/span><\/h3>\n\t<\/div>\n\t<\/section>\n\n\n<section id=\"block_0c61faefbfea2415427c4ca5cf8ca8f2\" class=\"block block--stat-callout \" role=\"region\" aria-labelledby=\"statCalloutTitle\" aria-describedby=\"statCalloutDesc\">\n\t<h2 id=\"statCalloutTitle\" class=\"sr-only\">Statistics Callout<\/h2> <!-- Add a hidden heading for accessibility -->\n\t<p id=\"statCalloutDesc\" class=\"sr-only\">This section presents key statistical information with numbers and descriptions.<\/p> <!-- Hidden description -->\n\n\t<!-- Changing container to ul for better semantics -->\n\t<ul class=\"container\" role=\"list\">\n\t\t\t\t\t\t<!-- Each card is now an li element for semantic correctness -->\n\t\t\t<li class=\"card\" id=\"block_0c61faefbfea2415427c4ca5cf8ca8f2-card-0\" role=\"listitem\" aria-labelledby=\"block_0c61faefbfea2415427c4ca5cf8ca8f2-card-0-number\" aria-describedby=\"block_0c61faefbfea2415427c4ca5cf8ca8f2-card-0-description\">\n\t\t\t\t<div class=\"card-top\">\n\t\t\t\t\t\t\t\t\t\t\t<div class=\"card-number\" id=\"block_0c61faefbfea2415427c4ca5cf8ca8f2-card-0-number\">85<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"card-symbol\">\n\t\t\t\t\t\t\t<span>%<\/span>\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t\t\t<div class=\"card-description font--p\" id=\"block_0c61faefbfea2415427c4ca5cf8ca8f2-card-0-description\">\n\t\t\t\t\t\tModerate-severe calcification\u2020\t\t\t\t\t<\/div>\n\t\t\t\t\n\t\t\t<\/li>\n\t\t\t\t\t<!-- Each card is now an li element for semantic correctness -->\n\t\t\t<li class=\"card\" id=\"block_0c61faefbfea2415427c4ca5cf8ca8f2-card-1\" role=\"listitem\" aria-labelledby=\"block_0c61faefbfea2415427c4ca5cf8ca8f2-card-1-number\" aria-describedby=\"block_0c61faefbfea2415427c4ca5cf8ca8f2-card-1-description\">\n\t\t\t\t<div class=\"card-top\">\n\t\t\t\t\t\t\t\t\t\t\t<div class=\"card-number\" id=\"block_0c61faefbfea2415427c4ca5cf8ca8f2-card-1-number\">91 mm<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"card-symbol\">\n\t\t\t\t\t\t\t<span><\/span>\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t\t\t<div class=\"card-description font--p\" id=\"block_0c61faefbfea2415427c4ca5cf8ca8f2-card-1-description\">\n\t\t\t\t\t\tMean calcified length \t\t\t\t\t<\/div>\n\t\t\t\t\n\t\t\t<\/li>\n\t\t\t\t\t<!-- Each card is now an li element for semantic correctness -->\n\t\t\t<li class=\"card\" id=\"block_0c61faefbfea2415427c4ca5cf8ca8f2-card-2\" role=\"listitem\" aria-labelledby=\"block_0c61faefbfea2415427c4ca5cf8ca8f2-card-2-number\" aria-describedby=\"block_0c61faefbfea2415427c4ca5cf8ca8f2-card-2-description\">\n\t\t\t\t<div class=\"card-top\">\n\t\t\t\t\t\t\t\t\t\t\t<div class=\"card-number\" id=\"block_0c61faefbfea2415427c4ca5cf8ca8f2-card-2-number\">30<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"card-symbol\">\n\t\t\t\t\t\t\t<span>%<\/span>\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t\t\t<div class=\"card-description font--p\" id=\"block_0c61faefbfea2415427c4ca5cf8ca8f2-card-2-description\">\n\t\t\t\t\t\tChronic total occlusions\t\t\t\t\t<\/div>\n\t\t\t\t\n\t\t\t<\/li>\n\t\t\t\t<\/ul>\n<\/section>\n\n\n<section id=\"block_98769378f85d8c787db8eba82f6c844c\" class=\"block block--wysiwyg wysiwyg_styles u-bgColorNone container\">\n\t<div class=\"u-wysiwyg u-animation\">\n\t\t<p><span class=\"legal_copy\">*Enrollment of RC3 was capped at 20% | \u2020PARC Definition<br \/>\n<\/span><span class=\"legal_copy\">Armstrong E, VIVA 2025<\/span><\/p>\n\t<\/div>\n\t<\/section>\n\n<section\n\tid=\"safety\"\n\tclass=\"block block--spacer-with-optional-divider \"\n\taria-label=\"Spacer section with optional divider\">\n\t<div class=\"spacer-with-optional-divider-container container\">\n\n\t\t<!-- Space Above -->\n\t\t<div\n\t\t\tclass=\"space-above\"\n\t\t\tstyle=\"--aboveDesktop: 60px; --aboveMobile: 30px;\"\n\t\t\taria-hidden=\"true\"\n\t\t\trole=\"presentation\">\n\t\t<\/div>\n\n\t\t<!-- Optional Divider -->\n\t\t\n\t\t<!-- Space Below -->\n\t\t<div\n\t\t\tclass=\"space-below\"\n\t\t\tstyle=\"--belowDesktop: 0px; --belowMobile: 0px;\"\n\t\t\taria-hidden=\"true\"\n\t\t\trole=\"presentation\">\n\t\t<\/div>\n\n\t<\/div>\n<\/section>\n\n\n<section id=\"block_98fb9317f6ed84c0dc51fa43f7aadccc\" class=\"block block--wysiwyg wysiwyg_styles u-bgColorNone container\">\n\t<div class=\"u-wysiwyg u-animation\">\n\t\t<h2>IVL\u2019s Safety Profile Confirmed in Challenging Calcium Below the Knee<\/h2>\n<p><span data-contrast=\"auto\">IVL was confirmed to be a safe treatment option in a challenging patient and lesion cohort.<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<h3 style=\"text-align: center;\">STRONG SAFETY PROFILE<\/h3>\n<table style=\"border-collapse: collapse; width: 100%; height: 216px;\">\n<tbody>\n<tr style=\"height: 24px;\">\n<td style=\"width: 33.3333%; height: 24px;\"><\/td>\n<td style=\"width: 33.3333%; height: 24px;\"><span class=\"TextRun SCXW122432471 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW122432471 BCX0\">Post-IVL<\/span><\/span><\/td>\n<td style=\"width: 33.3333%; height: 24px;\"><span class=\"TextRun SCXW225427357 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW225427357 BCX0\">Final<\/span><\/span><\/td>\n<\/tr>\n<tr style=\"height: 24px;\">\n<td style=\"width: 33.3333%; height: 24px; text-align: center;\"><strong><span class=\"TextRun SCXW112641530 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW112641530 BCX0\">N<\/span><\/span><span class=\"EOP SCXW112641530 BCX0\" data-ccp-props=\"{}\">\u00a0<\/span><\/strong><\/td>\n<td style=\"width: 33.3333%; height: 24px;\"><strong><span class=\"TextRun SCXW226834653 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW226834653 BCX0\">268 lesions<\/span><\/span><span class=\"EOP SCXW226834653 BCX0\" data-ccp-props=\"{}\">\u00a0<\/span><\/strong><\/td>\n<td style=\"width: 33.3333%; height: 24px;\"><strong><span class=\"TextRun SCXW252108997 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW252108997 BCX0\">290 lesions<\/span><\/span><span class=\"EOP SCXW252108997 BCX0\" data-ccp-props=\"{}\">\u00a0<\/span><\/strong><\/td>\n<\/tr>\n<tr style=\"height: 24px;\">\n<td style=\"width: 33.3333%; height: 24px; text-align: center;\"><span class=\"TextRun SCXW26051870 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW26051870 BCX0\">Any serious angiographic complication (total)<\/span><\/span><span class=\"EOP SCXW26051870 BCX0\" data-ccp-props=\"{}\">\u00a0<\/span><\/td>\n<td style=\"width: 33.3333%; height: 24px;\"><span class=\"TextRun SCXW158748398 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW158748398 BCX0\">1.9% (5\/268)<\/span><\/span><span class=\"EOP SCXW158748398 BCX0\" data-ccp-props=\"{}\">\u00a0<\/span><\/td>\n<td style=\"width: 33.3333%; height: 24px;\"><span class=\"TextRun SCXW4225702 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW4225702 BCX0\">1.0% (3\/290)<\/span><\/span><span class=\"EOP SCXW4225702 BCX0\" data-ccp-props=\"{}\">\u00a0<\/span><\/td>\n<\/tr>\n<tr style=\"height: 24px;\">\n<td style=\"width: 33.3333%; height: 24px; text-align: center;\"><span class=\"TextRun SCXW136254778 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW136254778 BCX0\">Dissection (Type D-F)<\/span><\/span><span class=\"EOP SCXW136254778 BCX0\" data-ccp-props=\"{}\">\u00a0<\/span><\/td>\n<td style=\"width: 33.3333%; height: 24px;\"><span class=\"TextRun SCXW216434561 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW216434561 BCX0\">0.7% (2\/268)<\/span><\/span><span class=\"EOP SCXW216434561 BCX0\" data-ccp-props=\"{}\">\u00a0<\/span><\/td>\n<td style=\"width: 33.3333%; height: 24px;\"><span class=\"TextRun SCXW266442671 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW266442671 BCX0\">0.3% (1\/290)<\/span><\/span><span class=\"EOP SCXW266442671 BCX0\" data-ccp-props=\"{}\">\u00a0<\/span><\/td>\n<\/tr>\n<tr style=\"height: 24px;\">\n<td style=\"width: 33.3333%; height: 24px; text-align: center;\"><span class=\"TextRun SCXW238666406 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW238666406 BCX0\">Total perforations<\/span><\/span><\/td>\n<td style=\"width: 33.3333%; height: 24px;\"><span class=\"TextRun SCXW30475419 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW30475419 BCX0\">1.5% (4\/268)<\/span><\/span><span class=\"EOP SCXW30475419 BCX0\" data-ccp-props=\"{}\">\u00a0<\/span><\/td>\n<td style=\"width: 33.3333%; height: 24px;\"><span class=\"TextRun SCXW129739653 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW129739653 BCX0\">0.7% (2\/290)<\/span><\/span><span class=\"EOP SCXW129739653 BCX0\" data-ccp-props=\"{}\">\u00a0<\/span><\/td>\n<\/tr>\n<tr style=\"height: 24px;\">\n<td style=\"width: 33.3333%; height: 24px; text-align: center;\"><span class=\"TextRun SCXW249134670 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW249134670 BCX0\">Distal embolization<\/span><\/span><sup><span class=\"TextRun SCXW249134670 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"auto\"><span class=\"NormalTextRun Superscript SCXW249134670 BCX0\" data-fontsize=\"12\">1<\/span><\/span><span class=\"EOP SCXW249134670 BCX0\" data-ccp-props=\"{}\">\u00a0<\/span><\/sup><\/td>\n<td style=\"width: 33.3333%; height: 24px;\"><span class=\"TextRun SCXW79538758 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW79538758 BCX0\">0% (0\/268)<\/span><\/span><span class=\"EOP SCXW79538758 BCX0\" data-ccp-props=\"{}\">\u00a0<\/span><\/td>\n<td style=\"width: 33.3333%; height: 24px;\"><span class=\"TextRun SCXW199267592 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW199267592 BCX0\">0% (0\/290)<\/span><\/span><span class=\"EOP SCXW199267592 BCX0\" data-ccp-props=\"{}\">\u00a0<\/span><\/td>\n<\/tr>\n<tr style=\"height: 24px;\">\n<td style=\"width: 33.3333%; height: 24px; text-align: center;\"><span class=\"TextRun SCXW3748780 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW3748780 BCX0\">Slow flow\/no reflow<\/span><\/span><sup><span class=\"TextRun SCXW3748780 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"auto\"><span class=\"NormalTextRun Superscript SCXW3748780 BCX0\" data-fontsize=\"12\">2<\/span><\/span><span class=\"EOP SCXW3748780 BCX0\" data-ccp-props=\"{}\">\u00a0<\/span><\/sup><\/td>\n<td style=\"width: 33.3333%; height: 24px;\"><span class=\"TextRun SCXW79538758 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW79538758 BCX0\">0% (0\/268)<\/span><\/span><span class=\"EOP SCXW79538758 BCX0\" data-ccp-props=\"{}\">\u00a0<\/span><\/td>\n<td style=\"width: 33.3333%; height: 24px;\"><span class=\"TextRun SCXW199267592 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW199267592 BCX0\">0% (0\/290)<\/span><\/span><span class=\"EOP SCXW199267592 BCX0\" data-ccp-props=\"{}\">\u00a0<\/span><\/td>\n<\/tr>\n<tr style=\"height: 24px;\">\n<td style=\"width: 33.3333%; height: 24px; text-align: center;\"><span class=\"TextRun SCXW114549342 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW114549342 BCX0\">Abrupt closure<\/span><\/span><span class=\"EOP SCXW114549342 BCX0\" data-ccp-props=\"{}\">\u00a0<\/span><\/td>\n<td style=\"width: 33.3333%; height: 24px;\"><span class=\"TextRun SCXW181722579 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW181722579 BCX0\">0.4% (1\/268)<\/span><\/span><span class=\"EOP SCXW181722579 BCX0\" data-ccp-props=\"{}\">\u00a0<\/span><\/td>\n<td style=\"width: 33.3333%; height: 24px;\"><span class=\"TextRun SCXW185765956 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW185765956 BCX0\">0.3% (1\/290)<\/span><\/span><span class=\"EOP SCXW185765956 BCX0\" data-ccp-props=\"{}\">\u00a0<\/span><\/td>\n<\/tr>\n<tr style=\"height: 24px;\">\n<td style=\"width: 33.3333%; height: 24px; text-align: center;\"><span class=\"TextRun SCXW91197518 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW91197518 BCX0\">Thrombus <\/span><\/span><span class=\"EOP SCXW91197518 BCX0\" data-ccp-props=\"{}\">\u00a0<\/span><\/td>\n<td style=\"width: 33.3333%; height: 24px;\"><span class=\"TextRun SCXW79538758 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW79538758 BCX0\">0% (0\/268)<\/span><\/span><span class=\"EOP SCXW79538758 BCX0\" data-ccp-props=\"{}\">\u00a0<\/span><\/td>\n<td style=\"width: 33.3333%; height: 24px;\"><span class=\"TextRun SCXW199267592 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW199267592 BCX0\">0% (0\/290)<\/span><\/span><span class=\"EOP SCXW199267592 BCX0\" data-ccp-props=\"{}\">\u00a0<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>\u00a0<\/p>\n<p><b><span data-contrast=\"auto\">Three patients with serious angiographic complications at final:<\/span><\/b><b><span data-contrast=\"auto\">\u00a0<\/span><\/b><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"7\" data-list-defn-props=\"{\"335552541\":1,\"335559685\":720,\"335559991\":360,\"469769226\":\"Symbol\",\"469769242\":[8226],\"469777803\":\"left\",\"469777804\":\"\uf0b7\",\"469777815\":\"hybridMultilevel\"}\" aria-setsize=\"-1\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"auto\">One patient had one undiagnosed minor perforation (Grade I)<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"7\" data-list-defn-props=\"{\"335552541\":1,\"335559685\":720,\"335559991\":360,\"469769226\":\"Symbol\",\"469769242\":[8226],\"469777803\":\"left\",\"469777804\":\"\uf0b7\",\"469777815\":\"hybridMultilevel\"}\" aria-setsize=\"-1\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"auto\">One patient had a Grade II perforation seen pre-IVL balloon inflation, downgraded to Grade I after DES placement<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"7\" data-list-defn-props=\"{\"335552541\":1,\"335559685\":720,\"335559991\":360,\"469769226\":\"Symbol\",\"469769242\":[8226],\"469777803\":\"left\",\"469777804\":\"\uf0b7\",\"469777815\":\"hybridMultilevel\"}\" aria-setsize=\"-1\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"auto\">One patient experienced abrupt vessel closure despite DES placement for grade F dissection<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><b><span data-contrast=\"auto\">None of the three patients had adverse events through discharge.<\/span><\/b><span data-ccp-props=\"{\"335559685\":0}\">\u00a0<\/span><\/p>\n<p><span class=\"legal_copy\">1: One patient had a distal thromboembolism post-IVL. Transluminal suction thrombectomy was performed and the event was successfully resolved although imaging was not provided to the core lab for assessment, therefore, data was not included in table.<br \/>\n2: No Reflow defined as reduced antegrade flow without evidence of residual stenosis or dissection at the treatment site.<br \/>\n<\/span><span class=\"legal_copy\">Chandra V, Lansky AJ, Sayfo S, et al. Thirty-Day Outcomes from the Disrupt PAD BTK II Study of the Shockwave Intravascular Lithotripsy System for Treatment of Calcified Below-the-Knee Peripheral Arterial Disease. Journal of Vascular Surgery. Published online November 12, 2024. doi:10.1016\/j.jvs.2024.11.003<\/span><\/p>\n\t<\/div>\n\t<\/section>\n\n<section\n\tid=\"block_41d3bcb93e9334b463a2405c965d7ded\"\n\tclass=\"block block--spacer-with-optional-divider \"\n\taria-label=\"Spacer section with optional divider\">\n\t<div class=\"spacer-with-optional-divider-container container\">\n\n\t\t<!-- Space Above -->\n\t\t<div\n\t\t\tclass=\"space-above\"\n\t\t\tstyle=\"--aboveDesktop: 60px; --aboveMobile: 30px;\"\n\t\t\taria-hidden=\"true\"\n\t\t\trole=\"presentation\">\n\t\t<\/div>\n\n\t\t<!-- Optional Divider -->\n\t\t\n\t\t<!-- Space Below -->\n\t\t<div\n\t\t\tclass=\"space-below\"\n\t\t\tstyle=\"--belowDesktop: 0px; --belowMobile: 0px;\"\n\t\t\taria-hidden=\"true\"\n\t\t\trole=\"presentation\">\n\t\t<\/div>\n\n\t<\/div>\n<\/section>\n\n\n<section id=\"block_ca1ea914b1880baeb783ddc28fcbae5b\" class=\"block block--wysiwyg wysiwyg_styles u-bgColorNone container\">\n\t<div class=\"u-wysiwyg u-animation\">\n\t\t<h2>IVL\u2019s Effectiveness Confirmed in Challenging Calcium Below the Knee<\/h2>\n<p><span data-contrast=\"auto\">IVL was confirmed to be effective at reducing lesion stenosis with minimal additional treatment therapy.<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<p><img decoding=\"async\" class=\"aligncenter wp-image-6680 size-large lazyload\" data-src=\"https:\/\/shockwavemedical.com\/wp-content\/uploads\/2024\/11\/Effective-Calcium-Modification-Graph-1024x941.png\" alt=\"Bar graph titled \"Proven Effective Calcium Modification\" illustrating changes in diameter stenosis over three stages: Pre-Procedure (78%), Post-IVL (29%), and Final (26%).\" width=\"1024\" height=\"941\" data-srcset=\"https:\/\/shockwavemedical.com\/wp-content\/uploads\/2024\/11\/Effective-Calcium-Modification-Graph-1024x941.png 1024w, https:\/\/shockwavemedical.com\/wp-content\/uploads\/2024\/11\/Effective-Calcium-Modification-Graph-300x276.png 300w, https:\/\/shockwavemedical.com\/wp-content\/uploads\/2024\/11\/Effective-Calcium-Modification-Graph-768x706.png 768w, https:\/\/shockwavemedical.com\/wp-content\/uploads\/2024\/11\/Effective-Calcium-Modification-Graph-1536x1411.png 1536w, https:\/\/shockwavemedical.com\/wp-content\/uploads\/2024\/11\/Effective-Calcium-Modification-Graph.png 1801w\" data-sizes=\"(max-width: 1024px) 100vw, 1024px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 1024px; --smush-placeholder-aspect-ratio: 1024\/941;\" \/><\/p>\n<h3 style=\"text-align: left;\">Primary Effectiveness Endpoint<\/h3>\n<ul>\n<li style=\"text-align: left;\">Final residual stenosis of <strong>\u2264 50%<\/strong> without serious angiographic complications: <strong>97.9%<\/strong> (232\/237, 95% CI 95.1%-99.3%)<\/li>\n<li>Additional analysis: Final residual stenosis of <strong>\u2264 30%<\/strong> without serious angiographic complications: <strong>74.1%<\/strong> (215\/290, 95% CI 68.7%-79.1%)<\/li>\n<\/ul>\n<p><span class=\"legal_copy\">Chandra V, Lansky AJ, Sayfo S, et al. Thirty-Day Outcomes from the Disrupt PAD BTK II Study of the Shockwave Intravascular Lithotripsy System for Treatment of Calcified Below-the-Knee Peripheral Arterial Disease. Journal of Vascular Surgery. Published online November 12, 2024. doi:10.1016\/j.jvs.2024.11.003<\/span><\/p>\n\t<\/div>\n\t<\/section>\n\n<section\n\tid=\"block_41d3bcb93e9334b463a2405c965d7ded\"\n\tclass=\"block block--spacer-with-optional-divider \"\n\taria-label=\"Spacer section with optional divider\">\n\t<div class=\"spacer-with-optional-divider-container container\">\n\n\t\t<!-- Space Above -->\n\t\t<div\n\t\t\tclass=\"space-above\"\n\t\t\tstyle=\"--aboveDesktop: 60px; --aboveMobile: 30px;\"\n\t\t\taria-hidden=\"true\"\n\t\t\trole=\"presentation\">\n\t\t<\/div>\n\n\t\t<!-- Optional Divider -->\n\t\t\n\t\t<!-- Space Below -->\n\t\t<div\n\t\t\tclass=\"space-below\"\n\t\t\tstyle=\"--belowDesktop: 0px; --belowMobile: 0px;\"\n\t\t\taria-hidden=\"true\"\n\t\t\trole=\"presentation\">\n\t\t<\/div>\n\n\t<\/div>\n<\/section>\n\n\n<section id=\"block_81ed785ef65e1ed15f6f2dcdf1dd9054\" class=\"block block--wysiwyg wysiwyg_styles u-bgColorNone container\">\n\t<div class=\"u-wysiwyg u-animation\">\n\t\t<h2>Procedural Information<\/h2>\n\t<\/div>\n\t<\/section>\n\n\n<section id=\"block_31b2d68ac22031dda781d16b9b2202f1\" class=\"block block--stat-callout \" role=\"region\" aria-labelledby=\"statCalloutTitle\" aria-describedby=\"statCalloutDesc\">\n\t<h2 id=\"statCalloutTitle\" class=\"sr-only\">Statistics Callout<\/h2> <!-- Add a hidden heading for accessibility -->\n\t<p id=\"statCalloutDesc\" class=\"sr-only\">This section presents key statistical information with numbers and descriptions.<\/p> <!-- Hidden description -->\n\n\t<!-- Changing container to ul for better semantics -->\n\t<ul class=\"container\" role=\"list\">\n\t\t\t\t\t\t<!-- Each card is now an li element for semantic correctness -->\n\t\t\t<li class=\"card\" id=\"block_31b2d68ac22031dda781d16b9b2202f1-card-0\" role=\"listitem\" aria-labelledby=\"block_31b2d68ac22031dda781d16b9b2202f1-card-0-number\" aria-describedby=\"block_31b2d68ac22031dda781d16b9b2202f1-card-0-description\">\n\t\t\t\t<div class=\"card-top\">\n\t\t\t\t\t\t\t\t\t\t\t<div class=\"card-number\" id=\"block_31b2d68ac22031dda781d16b9b2202f1-card-0-number\">65<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"card-symbol\">\n\t\t\t\t\t\t\t<span>%<\/span>\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t\t\t<div class=\"card-description font--p\" id=\"block_31b2d68ac22031dda781d16b9b2202f1-card-0-description\">\n\t\t\t\t\t\tNo pre-dilation\t\t\t\t\t<\/div>\n\t\t\t\t\n\t\t\t<\/li>\n\t\t\t\t\t<!-- Each card is now an li element for semantic correctness -->\n\t\t\t<li class=\"card\" id=\"block_31b2d68ac22031dda781d16b9b2202f1-card-1\" role=\"listitem\" aria-labelledby=\"block_31b2d68ac22031dda781d16b9b2202f1-card-1-number\" aria-describedby=\"block_31b2d68ac22031dda781d16b9b2202f1-card-1-description\">\n\t\t\t\t<div class=\"card-top\">\n\t\t\t\t\t\t\t\t\t\t\t<div class=\"card-number\" id=\"block_31b2d68ac22031dda781d16b9b2202f1-card-1-number\">65<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"card-symbol\">\n\t\t\t\t\t\t\t<span>%<\/span>\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t\t\t<div class=\"card-description font--p\" id=\"block_31b2d68ac22031dda781d16b9b2202f1-card-1-description\">\n\t\t\t\t\t\tNo post-dilation\t\t\t\t\t<\/div>\n\t\t\t\t\n\t\t\t<\/li>\n\t\t\t\t\t<!-- Each card is now an li element for semantic correctness -->\n\t\t\t<li class=\"card\" id=\"block_31b2d68ac22031dda781d16b9b2202f1-card-2\" role=\"listitem\" aria-labelledby=\"block_31b2d68ac22031dda781d16b9b2202f1-card-2-number\" aria-describedby=\"block_31b2d68ac22031dda781d16b9b2202f1-card-2-description\">\n\t\t\t\t<div class=\"card-top\">\n\t\t\t\t\t\t\t\t\t\t\t<div class=\"card-number\" id=\"block_31b2d68ac22031dda781d16b9b2202f1-card-2-number\">4.9<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"card-symbol\">\n\t\t\t\t\t\t\t<span>%<\/span>\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t\t\t<div class=\"card-description font--p\" id=\"block_31b2d68ac22031dda781d16b9b2202f1-card-2-description\">\n\t\t\t\t\t\tTotal stent\/tack implant\t\t\t\t\t<\/div>\n\t\t\t\t\n\t\t\t<\/li>\n\t\t\t\t\t<!-- Each card is now an li element for semantic correctness -->\n\t\t\t<li class=\"card\" id=\"block_31b2d68ac22031dda781d16b9b2202f1-card-3\" role=\"listitem\" aria-labelledby=\"block_31b2d68ac22031dda781d16b9b2202f1-card-3-number\" aria-describedby=\"block_31b2d68ac22031dda781d16b9b2202f1-card-3-description\">\n\t\t\t\t<div class=\"card-top\">\n\t\t\t\t\t\t\t\t\t\t\t<div class=\"card-number\" id=\"block_31b2d68ac22031dda781d16b9b2202f1-card-3-number\">2.3<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"card-symbol\">\n\t\t\t\t\t\t\t<span>%<\/span>\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t\t\t<div class=\"card-description font--p\" id=\"block_31b2d68ac22031dda781d16b9b2202f1-card-3-description\">\n\t\t\t\t\t\tProvisional stent\/tack implant*\t\t\t\t\t<\/div>\n\t\t\t\t\n\t\t\t<\/li>\n\t\t\t\t<\/ul>\n<\/section>\n\n\n<section id=\"block_26940c4b4f549f45e71fe37ccd66f318\" class=\"block block--wysiwyg wysiwyg_styles u-bgColorNone container\">\n\t<div class=\"u-wysiwyg u-animation\">\n\t\t<p><span class=\"legal_copy\">*Remaining stent\/tack implants were part of physicians\u2019 standard algorithm.<br \/>\n<span class=\"legal_copy\">Chandra V, Lansky AJ, Sayfo S, et al. Thirty-Day Outcomes from the Disrupt PAD BTK II Study of the Shockwave Intravascular Lithotripsy System for Treatment of Calcified Below-the-Knee Peripheral Arterial Disease. Journal of Vascular Surgery. Published online November 12, 2024. doi:10.1016\/j.jvs.2024.11.003<\/span><br \/>\n<\/span><\/p>\n\t<\/div>\n\t<\/section>\n\n<section\n\tid=\"thirty-days\"\n\tclass=\"block block--spacer-with-optional-divider \"\n\taria-label=\"Spacer section with optional divider\">\n\t<div class=\"spacer-with-optional-divider-container container\">\n\n\t\t<!-- Space Above -->\n\t\t<div\n\t\t\tclass=\"space-above\"\n\t\t\tstyle=\"--aboveDesktop: 60px; --aboveMobile: 30px;\"\n\t\t\taria-hidden=\"true\"\n\t\t\trole=\"presentation\">\n\t\t<\/div>\n\n\t\t<!-- Optional Divider -->\n\t\t\n\t\t<!-- Space Below -->\n\t\t<div\n\t\t\tclass=\"space-below\"\n\t\t\tstyle=\"--belowDesktop: 0px; --belowMobile: 0px;\"\n\t\t\taria-hidden=\"true\"\n\t\t\trole=\"presentation\">\n\t\t<\/div>\n\n\t<\/div>\n<\/section>\n\n\n<section id=\"block_118d3f6c3cba3ed192a3405569ff690d\" class=\"block block--wysiwyg wysiwyg_styles u-bgColorNone container\">\n\t<div class=\"u-wysiwyg u-animation\">\n\t\t<h2>Primary Safety Endpoint at 30-Days<\/h2>\n<p><span data-contrast=\"auto\">Results for the primary safety endpoint at 30-days further confirm IVL\u2019s safety and ongoing efficacy in challenging calcium below the knee.<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<table style=\"border-collapse: collapse; width: 100%; height: 144px;\">\n<tbody>\n<tr style=\"height: 24px;\">\n<td style=\"width: 63.0612%; height: 24px;\"><span class=\"TextRun Highlight SCXW156853585 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW156853585 BCX0\">Measure\u00a0<\/span><\/span><span class=\"EOP SCXW156853585 BCX0\" data-ccp-props=\"{}\">\u00a0<\/span><\/td>\n<td style=\"width: 18.8012%; height: 24px;\"><span class=\"TextRun Highlight SCXW256216465 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW256216465 BCX0\">Rate<\/span><\/span><span class=\"EOP SCXW256216465 BCX0\" data-ccp-props=\"{}\">\u00a0<\/span><\/td>\n<td style=\"width: 18.1375%; height: 24px;\"><span class=\"TextRun Highlight SCXW186681805 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW186681805 BCX0\">95% CI<\/span><\/span><span class=\"EOP SCXW186681805 BCX0\" data-ccp-props=\"{}\">\u00a0<\/span><\/td>\n<\/tr>\n<tr style=\"height: 48px;\">\n<td style=\"width: 63.0612%; height: 48px;\"><strong><span class=\"TextRun Highlight SCXW149479502 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW149479502 BCX0\">Major Adverse Limb Events (MALE) or Post-Operative Death (POD)<\/span><\/span><span class=\"EOP SCXW149479502 BCX0\" data-ccp-props=\"{}\">\u00a0<\/span><\/strong><\/td>\n<td style=\"width: 18.8012%; height: 48px;\"><span class=\"TextRun Highlight SCXW190020293 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW190020293 BCX0\">0.8% (2\/242)<\/span><\/span><span class=\"EOP SCXW190020293 BCX0\" data-ccp-props=\"{}\">\u00a0<\/span><\/td>\n<td style=\"width: 18.1375%; height: 48px;\"><span class=\"TextRun Highlight SCXW114633666 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW114633666 BCX0\">0.1% \u2013 3.0%<\/span><\/span><span class=\"EOP SCXW114633666 BCX0\" data-ccp-props=\"{}\">\u00a0<\/span><\/td>\n<\/tr>\n<tr style=\"height: 24px;\">\n<td style=\"width: 63.0612%; height: 24px;\"><span class=\"TextRun Highlight SCXW122735513 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW122735513 BCX0\">All-cause death<\/span><\/span><span class=\"EOP SCXW122735513 BCX0\" data-ccp-props=\"{}\">\u00a0<\/span><\/td>\n<td style=\"width: 18.8012%; height: 24px;\"><span class=\"TextRun Highlight SCXW173942026 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW173942026 BCX0\">0.0% (0\/242)<\/span><\/span><span class=\"EOP SCXW173942026 BCX0\" data-ccp-props=\"{}\">\u00a0<\/span><\/td>\n<td style=\"width: 18.1375%; height: 24px;\"><span class=\"TextRun Highlight SCXW52799539 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW52799539 BCX0\">0.0% \u2013 1.5%<\/span><\/span><span class=\"EOP SCXW52799539 BCX0\" data-ccp-props=\"{}\">\u00a0<\/span><\/td>\n<\/tr>\n<tr style=\"height: 24px;\">\n<td style=\"width: 63.0612%; height: 24px;\"><span class=\"TextRun Highlight SCXW34630365 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW34630365 BCX0\">Above-ankle amputation of the index limb<\/span><\/span><span class=\"EOP SCXW34630365 BCX0\" data-ccp-props=\"{}\">\u00a0<\/span><\/td>\n<td style=\"width: 18.8012%; height: 24px;\"><span class=\"TextRun Highlight SCXW190020293 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW190020293 BCX0\">0.8% (2\/242)<\/span><\/span><span class=\"EOP SCXW190020293 BCX0\" data-ccp-props=\"{}\">\u00a0<\/span><\/td>\n<td style=\"width: 18.1375%; height: 24px;\"><span class=\"TextRun Highlight SCXW114633666 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW114633666 BCX0\">0.1% \u2013 3.0%<\/span><\/span><span class=\"EOP SCXW114633666 BCX0\" data-ccp-props=\"{}\">\u00a0<\/span><\/td>\n<\/tr>\n<tr style=\"height: 24px;\">\n<td style=\"width: 63.0612%; height: 24px;\"><span class=\"TextRun Highlight SCXW241488031 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW241488031 BCX0\">Major reintervention<\/span><\/span><span class=\"EOP SCXW241488031 BCX0\" data-ccp-props=\"{}\">\u00a0<\/span><\/td>\n<td style=\"width: 18.8012%; height: 24px;\"><span class=\"TextRun Highlight SCXW173942026 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW173942026 BCX0\">0.0% (0\/242)<\/span><\/span><span class=\"EOP SCXW173942026 BCX0\" data-ccp-props=\"{}\">\u00a0<\/span><\/td>\n<td style=\"width: 18.1375%; height: 24px;\"><span class=\"TextRun Highlight SCXW52799539 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW52799539 BCX0\">0.0% \u2013 1.5%<\/span><\/span><span class=\"EOP SCXW52799539 BCX0\" data-ccp-props=\"{}\">\u00a0<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>\u00a0<\/p>\n<p><b><span data-contrast=\"auto\">Two patients required above-ankle amputations of the index limb:<\/span><\/b><b><span data-contrast=\"auto\">\u00a0<\/span><\/b><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"8\" data-list-defn-props=\"{\"335552541\":1,\"335559685\":720,\"335559991\":360,\"469769226\":\"Symbol\",\"469769242\":[8226],\"469777803\":\"left\",\"469777804\":\"\uf0b7\",\"469777815\":\"hybridMultilevel\"}\" aria-setsize=\"-1\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"auto\">One patient had worsening necrotizing fasciitis of the right foot and underwent amputation nine days after index procedure<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"8\" data-list-defn-props=\"{\"335552541\":1,\"335559685\":720,\"335559991\":360,\"469769226\":\"Symbol\",\"469769242\":[8226],\"469777803\":\"left\",\"469777804\":\"\uf0b7\",\"469777815\":\"hybridMultilevel\"}\" aria-setsize=\"-1\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"auto\">One patient had non healing wounds in multiple areas of the foot and had an amputation nine days after index procedure<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><b><span data-contrast=\"auto\">These events were reported as not related to the study device or procedure and the decision to amputate was made on clinical grounds by the treating physician.<\/span><\/b><\/p>\n<p><span data-ccp-props=\"{}\"><br \/>\n<span class=\"legal_copy\">Chandra V, Lansky AJ, Sayfo S, et al. Thirty-Day Outcomes from the Disrupt PAD BTK II Study of the Shockwave Intravascular Lithotripsy System for Treatment of Calcified Below-the-Knee Peripheral Arterial Disease. Journal of Vascular Surgery. Published online November 12, 2024. doi:10.1016\/j.jvs.2024.11.003<\/span><br \/>\n<\/span><\/p>\n\t<\/div>\n\t<\/section>\n\n<section\n\tid=\"month-12\"\n\tclass=\"block block--spacer-with-optional-divider \"\n\taria-label=\"Spacer section with optional divider\">\n\t<div class=\"spacer-with-optional-divider-container container\">\n\n\t\t<!-- Space Above -->\n\t\t<div\n\t\t\tclass=\"space-above\"\n\t\t\tstyle=\"--aboveDesktop: 60px; --aboveMobile: 30px;\"\n\t\t\taria-hidden=\"true\"\n\t\t\trole=\"presentation\">\n\t\t<\/div>\n\n\t\t<!-- Optional Divider -->\n\t\t\n\t\t<!-- Space Below -->\n\t\t<div\n\t\t\tclass=\"space-below\"\n\t\t\tstyle=\"--belowDesktop: 0px; --belowMobile: 0px;\"\n\t\t\taria-hidden=\"true\"\n\t\t\trole=\"presentation\">\n\t\t<\/div>\n\n\t<\/div>\n<\/section>\n\n\n<section id=\"block_7f2905e79d14ae47773929cb5705a5e3\" class=\"block block--wysiwyg wysiwyg_styles u-bgColorNone container\">\n\t<div class=\"u-wysiwyg u-animation\">\n\t\t<h2>Freedom from CD-TLR and Patency at 12 Months<\/h2>\n<p>12-month outcomes confirm the durability of IVL through sustained vessel patency and low reintervention rates which lead to limb preservation and ongoing symptom relief.<\/p>\n<p><img decoding=\"async\" class=\"aligncenter wp-image-13036 size-full lazyload\" data-src=\"https:\/\/shockwavemedical.com\/wp-content\/uploads\/2025\/11\/BTK-II-CLTI-Cohort-Freedom-from-CD-TLR-Graphic.png\" alt=\"\" width=\"2000\" height=\"715\" data-srcset=\"https:\/\/shockwavemedical.com\/wp-content\/uploads\/2025\/11\/BTK-II-CLTI-Cohort-Freedom-from-CD-TLR-Graphic.png 2000w, https:\/\/shockwavemedical.com\/wp-content\/uploads\/2025\/11\/BTK-II-CLTI-Cohort-Freedom-from-CD-TLR-Graphic-300x107.png 300w, https:\/\/shockwavemedical.com\/wp-content\/uploads\/2025\/11\/BTK-II-CLTI-Cohort-Freedom-from-CD-TLR-Graphic-1024x366.png 1024w, https:\/\/shockwavemedical.com\/wp-content\/uploads\/2025\/11\/BTK-II-CLTI-Cohort-Freedom-from-CD-TLR-Graphic-768x275.png 768w, https:\/\/shockwavemedical.com\/wp-content\/uploads\/2025\/11\/BTK-II-CLTI-Cohort-Freedom-from-CD-TLR-Graphic-1536x549.png 1536w\" data-sizes=\"(max-width: 2000px) 100vw, 2000px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 2000px; --smush-placeholder-aspect-ratio: 2000\/715;\" \/><\/p>\n<table style=\"border-collapse: collapse; width: 100%; height: 144px;\">\n<tbody>\n<tr style=\"height: 24px;\">\n<td style=\"width: 50%; height: 24px;\">Rutherford Category<\/td>\n<td style=\"width: 50%; height: 24px;\">Freedom from CD-TLR at 12 Months<\/td>\n<\/tr>\n<tr style=\"height: 24px;\">\n<td style=\"width: 50%; height: 24px;\">Full Cohort (n=250)<\/td>\n<td style=\"width: 50%; height: 24px;\">84.5%<\/td>\n<\/tr>\n<tr style=\"height: 24px;\">\n<td style=\"width: 50%; height: 24px;\">RC 3 (n=50)<\/td>\n<td style=\"width: 50%; height: 24px;\">92.0%<\/td>\n<\/tr>\n<tr style=\"height: 24px;\">\n<td style=\"width: 50%; height: 24px;\">CLTI (n=200)<\/td>\n<td style=\"width: 50%; height: 24px;\">82.7%<\/td>\n<\/tr>\n<tr style=\"height: 24px;\">\n<td style=\"width: 50%; height: 24px; text-align: center;\" colspan=\"2\"><strong>Patency at 12 Months<\/strong><\/td>\n<\/tr>\n<tr style=\"height: 24px;\">\n<td style=\"width: 50%; height: 24px; text-align: center;\" colspan=\"2\">67.1% (94\/140)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>\u00a0<\/p>\n<p><span class=\"legal_copy\">Armstrong E, VIVA 2025 | Clinically driven target revascularization (CD-TLR). | Kaplan Meier (KM) is an analysis that uses probability to capture patients lost to follow-up. | Freedom from CD-TLR analysis excluded patients with above the ankle amputation of target limb.<\/span><\/p>\n\t<\/div>\n\t<\/section>\n\n<section\n\tid=\"block_41d3bcb93e9334b463a2405c965d7ded\"\n\tclass=\"block block--spacer-with-optional-divider \"\n\taria-label=\"Spacer section with optional divider\">\n\t<div class=\"spacer-with-optional-divider-container container\">\n\n\t\t<!-- Space Above -->\n\t\t<div\n\t\t\tclass=\"space-above\"\n\t\t\tstyle=\"--aboveDesktop: 60px; --aboveMobile: 30px;\"\n\t\t\taria-hidden=\"true\"\n\t\t\trole=\"presentation\">\n\t\t<\/div>\n\n\t\t<!-- Optional Divider -->\n\t\t\n\t\t<!-- Space Below -->\n\t\t<div\n\t\t\tclass=\"space-below\"\n\t\t\tstyle=\"--belowDesktop: 0px; --belowMobile: 0px;\"\n\t\t\taria-hidden=\"true\"\n\t\t\trole=\"presentation\">\n\t\t<\/div>\n\n\t<\/div>\n<\/section>\n\n\n<section id=\"block_916fdd2ed07193382c3487e05d0578b2\" class=\"block block--wysiwyg wysiwyg_styles u-bgColorNone container\">\n\t<div class=\"u-wysiwyg u-animation\">\n\t\t<h2>Freedom from Major Amputation at 12 Months<\/h2>\n<p>12-month outcomes establish IVL\u2019s role in limb salvage and enabling functional recovery.<\/p>\n<p><img decoding=\"async\" class=\"aligncenter wp-image-13028 size-full lazyload\" data-src=\"https:\/\/shockwavemedical.com\/wp-content\/uploads\/2025\/11\/BTK-II-CLTI-Cohort-Freedom-from-Major-Amputation-Graphic.png\" alt=\"\" width=\"2000\" height=\"715\" data-srcset=\"https:\/\/shockwavemedical.com\/wp-content\/uploads\/2025\/11\/BTK-II-CLTI-Cohort-Freedom-from-Major-Amputation-Graphic.png 2000w, https:\/\/shockwavemedical.com\/wp-content\/uploads\/2025\/11\/BTK-II-CLTI-Cohort-Freedom-from-Major-Amputation-Graphic-300x107.png 300w, https:\/\/shockwavemedical.com\/wp-content\/uploads\/2025\/11\/BTK-II-CLTI-Cohort-Freedom-from-Major-Amputation-Graphic-1024x366.png 1024w, https:\/\/shockwavemedical.com\/wp-content\/uploads\/2025\/11\/BTK-II-CLTI-Cohort-Freedom-from-Major-Amputation-Graphic-768x275.png 768w, https:\/\/shockwavemedical.com\/wp-content\/uploads\/2025\/11\/BTK-II-CLTI-Cohort-Freedom-from-Major-Amputation-Graphic-1536x549.png 1536w\" data-sizes=\"(max-width: 2000px) 100vw, 2000px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 2000px; --smush-placeholder-aspect-ratio: 2000\/715;\" \/><\/p>\n<table style=\"border-collapse: collapse; width: 100%; height: 96px;\">\n<tbody>\n<tr style=\"height: 24px;\">\n<td style=\"width: 50%; height: 24px;\">Rutherford Category<\/td>\n<td style=\"width: 50%; height: 24px;\">Freedom from Amputation at 12 Months<\/td>\n<\/tr>\n<tr style=\"height: 24px;\">\n<td style=\"width: 50%; height: 24px;\">Full Cohort (n=250)<\/td>\n<td style=\"width: 50%; height: 24px;\">94.8%<\/td>\n<\/tr>\n<tr style=\"height: 24px;\">\n<td style=\"width: 50%; height: 24px;\">RC 3 (n=50)<\/td>\n<td style=\"width: 50%; height: 24px;\">100%<\/td>\n<\/tr>\n<tr style=\"height: 24px;\">\n<td style=\"width: 50%; height: 24px;\">CLTI (n=200)<\/td>\n<td style=\"width: 50%; height: 24px;\">93.3%<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>\u00a0<\/p>\n<p><span class=\"legal_copy\">Armstrong E, VIVA 2025 | Kaplan Meier (KM) is an analysis that uses probability to capture patients lost to follow-up.<\/span><\/p>\n\t<\/div>\n\t<\/section>\n\n<section\n\tid=\"block_41d3bcb93e9334b463a2405c965d7ded\"\n\tclass=\"block block--spacer-with-optional-divider \"\n\taria-label=\"Spacer section with optional divider\">\n\t<div class=\"spacer-with-optional-divider-container container\">\n\n\t\t<!-- Space Above -->\n\t\t<div\n\t\t\tclass=\"space-above\"\n\t\t\tstyle=\"--aboveDesktop: 60px; --aboveMobile: 30px;\"\n\t\t\taria-hidden=\"true\"\n\t\t\trole=\"presentation\">\n\t\t<\/div>\n\n\t\t<!-- Optional Divider -->\n\t\t\n\t\t<!-- Space Below -->\n\t\t<div\n\t\t\tclass=\"space-below\"\n\t\t\tstyle=\"--belowDesktop: 0px; --belowMobile: 0px;\"\n\t\t\taria-hidden=\"true\"\n\t\t\trole=\"presentation\">\n\t\t<\/div>\n\n\t<\/div>\n<\/section>\n\n\n<section id=\"block_36b478cfb2267c53941a884114c129ab\" class=\"block block--wysiwyg wysiwyg_styles u-bgColorNone container\">\n\t<div class=\"u-wysiwyg u-animation\">\n\t\t<h2>Rutherford Classification at 12 Months<\/h2>\n<p>In a majority of patients with CLTI, IVL plays a critical role in laying the foundation for successful wound healing through safe and effective revascularization<\/p>\n<ul>\n<li>At baseline, 80% of patients experienced CLTI which improved to just 25.1% in patients with available 12-months follow-up<\/li>\n<li>61% of wounds were healed or improving*<\/li>\n<\/ul>\n<p><img decoding=\"async\" class=\"aligncenter wp-image-13407 size-full lazyload\" data-src=\"https:\/\/shockwavemedical.com\/wp-content\/uploads\/2026\/02\/DISRUPT-BTK-II-Rutherford-Classification-at-12-Months-Bar-Chart.jpg\" alt=\"\" width=\"2000\" height=\"739\" data-srcset=\"https:\/\/shockwavemedical.com\/wp-content\/uploads\/2026\/02\/DISRUPT-BTK-II-Rutherford-Classification-at-12-Months-Bar-Chart.jpg 2000w, https:\/\/shockwavemedical.com\/wp-content\/uploads\/2026\/02\/DISRUPT-BTK-II-Rutherford-Classification-at-12-Months-Bar-Chart-300x111.jpg 300w, https:\/\/shockwavemedical.com\/wp-content\/uploads\/2026\/02\/DISRUPT-BTK-II-Rutherford-Classification-at-12-Months-Bar-Chart-1024x378.jpg 1024w, https:\/\/shockwavemedical.com\/wp-content\/uploads\/2026\/02\/DISRUPT-BTK-II-Rutherford-Classification-at-12-Months-Bar-Chart-768x284.jpg 768w, https:\/\/shockwavemedical.com\/wp-content\/uploads\/2026\/02\/DISRUPT-BTK-II-Rutherford-Classification-at-12-Months-Bar-Chart-1536x568.jpg 1536w\" data-sizes=\"(max-width: 2000px) 100vw, 2000px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 2000px; --smush-placeholder-aspect-ratio: 2000\/739;\" \/><\/p>\n<p><span class=\"legal_copy\">Armstrong E, VIVA 2025<br \/>\n*Mean Wound Follow Up Time: 157 days<br \/>\nAvailable data at 12 months is 159 limbs out of 251 limbs.<\/span><\/p>\n\t<\/div>\n\t<\/section>\n\n<section\n\tid=\"block_41d3bcb93e9334b463a2405c965d7ded\"\n\tclass=\"block block--spacer-with-optional-divider \"\n\taria-label=\"Spacer section with optional divider\">\n\t<div class=\"spacer-with-optional-divider-container container\">\n\n\t\t<!-- Space Above -->\n\t\t<div\n\t\t\tclass=\"space-above\"\n\t\t\tstyle=\"--aboveDesktop: 60px; --aboveMobile: 30px;\"\n\t\t\taria-hidden=\"true\"\n\t\t\trole=\"presentation\">\n\t\t<\/div>\n\n\t\t<!-- Optional Divider -->\n\t\t\n\t\t<!-- Space Below -->\n\t\t<div\n\t\t\tclass=\"space-below\"\n\t\t\tstyle=\"--belowDesktop: 0px; --belowMobile: 0px;\"\n\t\t\taria-hidden=\"true\"\n\t\t\trole=\"presentation\">\n\t\t<\/div>\n\n\t<\/div>\n<\/section>\n\n\n<section id=\"block_da9f09b94221a4f281d1833422aaef93\" class=\"block block--wysiwyg wysiwyg_styles u-bgColorNone container\">\n\t<div class=\"u-wysiwyg u-animation\">\n\t\t<h2>Quality of Life (QoL) at 12 Months<\/h2>\n<p>As part of revascularization, IVL facilitates sustained symptom improvement through 12 months.<\/p>\n<table style=\"border-collapse: collapse; width: 100%;\">\n<tbody>\n<tr>\n<td style=\"width: 14.2857%;\">VascuQoL-6 Attribute<\/td>\n<td style=\"width: 14.2857%;\">Activity<\/td>\n<td style=\"width: 14.2857%;\">Tired<\/td>\n<td style=\"width: 14.2857%;\">Walk<\/td>\n<td style=\"width: 14.2857%;\">Concern<\/td>\n<td style=\"width: 14.2857%;\">Social<\/td>\n<td style=\"width: 14.2857%;\">Pain<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 14.2857%;\">Average Score<br \/>\n12 Months (RC 3)<\/td>\n<td style=\"width: 14.2857%;\">3.1<\/td>\n<td style=\"width: 14.2857%;\">2.8<\/td>\n<td style=\"width: 14.2857%;\">3.1<\/td>\n<td style=\"width: 14.2857%;\">3.2<\/td>\n<td style=\"width: 14.2857%;\">3.4<\/td>\n<td style=\"width: 14.2857%;\">2.9<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 14.2857%;\">Average Score<br \/>\n12 Months (CLTI)<\/td>\n<td style=\"width: 14.2857%;\">2.8<\/td>\n<td style=\"width: 14.2857%;\">2.6<\/td>\n<td style=\"width: 14.2857%;\">3.0<\/td>\n<td style=\"width: 14.2857%;\">2.9<\/td>\n<td style=\"width: 14.2857%;\">3.1<\/td>\n<td style=\"width: 14.2857%;\">2.8<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 14.2857%;\">Average Score<br \/>\nBaseline (RC 3)<\/td>\n<td style=\"width: 14.2857%;\">1.9<\/td>\n<td style=\"width: 14.2857%;\">2.0<\/td>\n<td style=\"width: 14.2857%;\">2.3<\/td>\n<td style=\"width: 14.2857%;\">2.1<\/td>\n<td style=\"width: 14.2857%;\">2.6<\/td>\n<td style=\"width: 14.2857%;\">1.9<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 14.2857%;\">Average Score<br \/>\nBaseline (CLTI)<\/td>\n<td style=\"width: 14.2857%;\">1.9<\/td>\n<td style=\"width: 14.2857%;\">2.0<\/td>\n<td style=\"width: 14.2857%;\">2.3<\/td>\n<td style=\"width: 14.2857%;\">1.7<\/td>\n<td style=\"width: 14.2857%;\">2.3<\/td>\n<td style=\"width: 14.2857%;\">1.8<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>\u00a0<\/p>\n<ul>\n<li>All categories improved. Total VascuQoL-6 Score for both RC 3 and CLTI at 12 months significantly improved from baseline (P-Value: p<0.001).<\/li>\n<li>RC 3: Total at 12 months was 18.5 \u00b1 4.7 and total at baseline was 12.9 \u00b1 3.8.<\/li>\n<li>CLTI: Total at 12 months was 17.2 \u00b1 5.0 and total at baseline was 11.9 \u00b1 4.0.<\/li>\n<\/ul>\n<p><span class=\"legal_copy\">Armstrong E, VIVA 2025 | The Vascular Quality of Life Questionnaire is a survey used to determine health related quality of life (HRQoL) in patients with peripheral arterial disease (PAD). Each attribute is scored 1-4, a higher value indicates better health status. The sum of each individual attribute score is used to generate a total quality of life score<\/span><\/p>\n\t<\/div>\n\t<\/section>\n\n<section\n\tid=\"block_41d3bcb93e9334b463a2405c965d7ded\"\n\tclass=\"block block--spacer-with-optional-divider \"\n\taria-label=\"Spacer section with optional divider\">\n\t<div class=\"spacer-with-optional-divider-container container\">\n\n\t\t<!-- Space Above -->\n\t\t<div\n\t\t\tclass=\"space-above\"\n\t\t\tstyle=\"--aboveDesktop: 60px; --aboveMobile: 30px;\"\n\t\t\taria-hidden=\"true\"\n\t\t\trole=\"presentation\">\n\t\t<\/div>\n\n\t\t<!-- Optional Divider -->\n\t\t\n\t\t<!-- Space Below -->\n\t\t<div\n\t\t\tclass=\"space-below\"\n\t\t\tstyle=\"--belowDesktop: 0px; --belowMobile: 0px;\"\n\t\t\taria-hidden=\"true\"\n\t\t\trole=\"presentation\">\n\t\t<\/div>\n\n\t<\/div>\n<\/section>\n\n\n<section id=\"block_92030541aad49460f68eaf75374e7dce\" class=\"block block--cta-button-bar text_colors \">\n\t<div class=\"cta-button-bar--container\">\n\t\t<h2 id=\"block_92030541aad49460f68eaf75374e7dce-heading\" class=\"heading\">\n\t\t\tCheck out the DISRUPT BTK II 30-day Outcomes Publication to learn more\t\t<\/h2>\n\t\t<div class=\"buttons\">\n\t\t\t\t\t\t\t<ul class=\"cta-button-bar--links-container\" role=\"list\" aria-label=\"Call-to-action buttons\">\n\t\t\t\t\t\t\t\t\t\t\t<li class=\"resource-list--link\" role=\"listitem\">\n\t\t\t\t\t\t\t\n<a data-atom=\"button\" class=\"on-blue btn--primary\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39536842\/\" target=\"_blank\" aria-label=\"Read More - opens in a new tab\" rel=\"noopener\">Read More<i aria-hidden=\"true\" class=\"fa-sharp fa-arrow-right fa-solid\"><\/i><\/a>\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t\t<\/ul>\n\t\t\t\t\t<\/div>\n\t<\/div>\n<\/section>\n\n<section\n\tid=\"block_358ba80a1d69d18b6a85a8b6bca2c48b\"\n\tclass=\"block block--spacer-with-optional-divider \"\n\taria-label=\"Spacer section with optional divider\">\n\t<div class=\"spacer-with-optional-divider-container container\">\n\n\t\t<!-- Space Above -->\n\t\t<div\n\t\t\tclass=\"space-above\"\n\t\t\tstyle=\"--aboveDesktop: 30px; --aboveMobile: 20px;\"\n\t\t\taria-hidden=\"true\"\n\t\t\trole=\"presentation\">\n\t\t<\/div>\n\n\t\t<!-- Optional Divider -->\n\t\t\n\t\t<!-- Space Below -->\n\t\t<div\n\t\t\tclass=\"space-below\"\n\t\t\tstyle=\"--belowDesktop: 0px; --belowMobile: 0px;\"\n\t\t\taria-hidden=\"true\"\n\t\t\trole=\"presentation\">\n\t\t<\/div>\n\n\t<\/div>\n<\/section>\n\n\n<section id=\"block_fa518f241e4839d447f74717145f0824\" class=\"block block--content-2-up-with-optional-image \" aria-labelledby=\"section-heading-block_fa518f241e4839d447f74717145f0824\">\n\t<div class=\"content-container\">\n\t\t<ul class=\"cards\" role=\"list\">\n\t\t\t\t\t\t\t\t\t\t\t\t<li class=\"card\" role=\"listitem\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"card-image\">\n\t\t\t\t\t\t\t\t<img decoding=\"async\" data-src=\"https:\/\/shockwavemedical.com\/wp-content\/uploads\/2025\/03\/video-screenshot-2-dirsupt-1.jpg\"\n\t\t\t\t\t\t\t\t\talt=\"screenshot from video of doctor speaking\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" class=\"lazyload\" style=\"--smush-placeholder-width: 1280px; --smush-placeholder-aspect-ratio: 1280\/720;\" \/>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\n\t\t\t\t\t\t<!-- Card Content and Button Container -->\n\t\t\t\t\t\t<div class=\"card-content-link-container\">\n\n\t\t\t\t\t\t\t<div class=\"card-content-link wysiwyg_styles\">\n\t\t\t\t\t\t\t\t<!-- Card Content -->\n\t\t\t\t\t\t\t\t<div class=\"card-content u-wysiwyg u-animation\">\n\t\t\t\t\t\t\t\t\t<h3>DISRUPT BTK II Acute Outcomes: Physician Perspectives with Dr. Lakshminarayan & Prof. Holden<\/h3>\n\t\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t\t<!-- Button Container -->\n\t\t\t\t\t\t\t\t<div class=\"button-container\">\n\t\t\t\t\t\t\t\t\t\n<a data-atom=\"button\" class=\"optional-button btn--secondary\" href=\"https:\/\/shockwavemedical.com\/de\/education\/disrupt-btk-ii-acute-outcomes-physician-perspectives-with-prof-holden-dr-lakshminarayan\/\" target=\"_self\" aria-label=\"Watch the Video - link to page\">Watch the Video<i aria-hidden=\"true\" class=\"fa-sharp fa-arrow-right fa-light\"><\/i><\/a>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t\t<li class=\"card\" role=\"listitem\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"card-image\">\n\t\t\t\t\t\t\t\t<img decoding=\"async\" data-src=\"https:\/\/shockwavemedical.com\/wp-content\/uploads\/2025\/03\/video-screenshot-1-disrupt-1.jpg\"\n\t\t\t\t\t\t\t\t\talt=\"screenshot from video of doctor speaking\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" class=\"lazyload\" style=\"--smush-placeholder-width: 1280px; --smush-placeholder-aspect-ratio: 1280\/720;\" \/>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\n\t\t\t\t\t\t<!-- Card Content and Button Container -->\n\t\t\t\t\t\t<div class=\"card-content-link-container\">\n\n\t\t\t\t\t\t\t<div class=\"card-content-link wysiwyg_styles\">\n\t\t\t\t\t\t\t\t<!-- Card Content -->\n\t\t\t\t\t\t\t\t<div class=\"card-content u-wysiwyg u-animation\">\n\t\t\t\t\t\t\t\t\t<h3>DISRUPT BTK II Acute & 30-Day Outcomes with Dr. Venita Chandra and Dr. Ehrin Armstrong<\/h3>\n\t\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t\t<!-- Button Container -->\n\t\t\t\t\t\t\t\t<div class=\"button-container\">\n\t\t\t\t\t\t\t\t\t\n<a data-atom=\"button\" class=\"optional-button btn--secondary\" href=\"https:\/\/shockwavemedical.com\/de\/education\/disrupt-btk-ii-acute-30-day-outcomes-with-dr-venita-chandra-and-dr-ehrin-armstrong\/\" target=\"_self\" aria-label=\"Watch the video - link to page\">Watch the video<i aria-hidden=\"true\" class=\"fa-sharp fa-arrow-right fa-light\"><\/i><\/a>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t\t<\/ul>\n\t<\/div>\n<\/section>\n\n<section id=\"block_d92ac4451995554e187640300594ade5\" class=\"block block--featured-clinical-evidence \" aria-labelledby=\"featured-clinical-evidence-title\">\n\t\t\t<div class=\"featured-clinical-evidence--top text_colors \">\n\t\t\t<div class=\"featured-clinical-evidence--title\">\n\t\t\t\t\t\t\t\t\t<h2 id=\"featured-clinical-evidence-title\" class=\"heading\">More Shockwave Peripheral IVL Studies <\/h2>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"featured-clinical-evidence__btn-wrap featured-clinical-evidence__btn-wrap-top u--hidden u-md-block\">\n\t\t\t\t\t\t\n<a data-atom=\"button\" class=\" btn--secondary\" href=\"https:\/\/shockwavemedical.com\/de\/clinical-evidence\/\" target=\"_self\" aria-label=\"See All Clinical Evidence - link to page\">See All Clinical Evidence<i aria-hidden=\"true\" class=\"fa-sharp fa-arrow-right fa-light\"><\/i><\/a>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\n\t\t\t\t\t\t\t<div class=\"featured-clinical-evidence__btn-wrap featured-clinical-evidence__btn-wrap-bottom u--block u-md-hidden\">\n\t\t\t\t\t\n<a data-atom=\"button\" class=\" btn--secondary\" href=\"https:\/\/shockwavemedical.com\/de\/clinical-evidence\/\" target=\"_self\" aria-label=\"See All Clinical Evidence - link to page\">See All Clinical Evidence<i aria-hidden=\"true\" class=\"fa-sharp fa-arrow-right fa-light\"><\/i><\/a>\t\t\t\t<\/div>\n\t\t\t\n\t\t\t\t\t<\/div>\n\t\t<ul class=\"featured-clinical-evidence-list text_colors\" role=\"list\">\n\t\t\t\t\t\t<li class=\"featured-clinical-evidence-item\" role=\"listitem\" aria-labelledby=\"post-title-6608\" aria-describedby=\"post-category-6608 post-excerpt-6608\">\n\t\t\t\t\t<div class=\"featured-clinical-evidence-item--text-container\" id=\"post-title-6608\">\n\t\t\t\t\t\t<a href=\"https:\/\/shockwavemedical.com\/de\/clinical-evidence\/btk\/\" class=\"featured-clinical-evidence-item--title\">\n\t\t\t\t\t\t\tDISRUPT BTK\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"featured-clinical-evidence-item--arrow\" aria-hidden=\"true\"><svg width=\"25\" height=\"27\" viewBox=\"0 0 25 27\" fill=\"none\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M3.5 26H21a2.5 2.5 0 002.5-2.5V7.875L16.625 1H6a2.5 2.5 0 00-2.5 2.5v3.75\" stroke=\"#5B6770\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\"\/><path d=\"M16 1v7.5h7.5M4.75 19.75a3.75 3.75 0 100-7.498 3.75 3.75 0 000 7.498v0zm5 1.25l-1.875-1.875\" stroke=\"#5B6770\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\"\/><\/svg><\/div>\n\t\t\t\t\t\t<div class=\"featured-clinical-evidence-item--arrow-hover\" aria-hidden=\"true\"><svg width=\"25\" height=\"27\" viewBox=\"0 0 25 27\" fill=\"none\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M3.5 26H21a2.5 2.5 0 002.5-2.5V7.875L16.625 1H6a2.5 2.5 0 00-2.5 2.5v3.75\" stroke=\"#00D2FF\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\"\/><path d=\"M16 1v7.5h7.5M4.75 19.75a3.75 3.75 0 100-7.498 3.75 3.75 0 000 7.498v0zm5 1.25l-1.875-1.875\" stroke=\"#00D2FF\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\"\/><\/svg><\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t<div class=\"featured-clinical-evidence-item--excerpt\" id=\"post-excerpt-6608\">\n\t\t\t\t\t\tPost-market, European study to assess the safety and performance of Shockwave IVL as a standalone therapy in heavily calcified infrapopliteal lesions out to 30 days.\t\t\t\t\t<\/div>\n\t\t\t\t\t<div class=\"featured-clinical-evidence-item--category\" id=\"post-category-6608\">\n\t\t\t\t\t\tPeripheral IVL\t\t\t\t\t<\/div>\n\t\t\t\t<\/li>\n\t\t\t\t\t\t<li class=\"featured-clinical-evidence-item\" role=\"listitem\" aria-labelledby=\"post-title-6555\" aria-describedby=\"post-category-6555 post-excerpt-6555\">\n\t\t\t\t\t<div class=\"featured-clinical-evidence-item--text-container\" id=\"post-title-6555\">\n\t\t\t\t\t\t<a href=\"https:\/\/shockwavemedical.com\/de\/clinical-evidence\/pad-iii-rct\/\" class=\"featured-clinical-evidence-item--title\">\n\t\t\t\t\t\t\tDISRUPT PAD III Randomized Clinical Trial\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"featured-clinical-evidence-item--arrow\" aria-hidden=\"true\"><svg width=\"25\" height=\"27\" viewBox=\"0 0 25 27\" fill=\"none\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M3.5 26H21a2.5 2.5 0 002.5-2.5V7.875L16.625 1H6a2.5 2.5 0 00-2.5 2.5v3.75\" stroke=\"#5B6770\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\"\/><path d=\"M16 1v7.5h7.5M4.75 19.75a3.75 3.75 0 100-7.498 3.75 3.75 0 000 7.498v0zm5 1.25l-1.875-1.875\" stroke=\"#5B6770\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\"\/><\/svg><\/div>\n\t\t\t\t\t\t<div class=\"featured-clinical-evidence-item--arrow-hover\" aria-hidden=\"true\"><svg width=\"25\" height=\"27\" viewBox=\"0 0 25 27\" fill=\"none\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M3.5 26H21a2.5 2.5 0 002.5-2.5V7.875L16.625 1H6a2.5 2.5 0 00-2.5 2.5v3.75\" stroke=\"#00D2FF\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\"\/><path d=\"M16 1v7.5h7.5M4.75 19.75a3.75 3.75 0 100-7.498 3.75 3.75 0 000 7.498v0zm5 1.25l-1.875-1.875\" stroke=\"#00D2FF\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\"\/><\/svg><\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t<div class=\"featured-clinical-evidence-item--excerpt\" id=\"post-excerpt-6555\">\n\t\t\t\t\t\tThe largest-ever randomized clinical study of Shockwave peripheral IVL treatment in severely calcified peripheral lesions, out to 24 months.\t\t\t\t\t<\/div>\n\t\t\t\t\t<div class=\"featured-clinical-evidence-item--category\" id=\"post-category-6555\">\n\t\t\t\t\t\tPeripheral IVL\t\t\t\t\t<\/div>\n\t\t\t\t<\/li>\n\t\t\t\t\t\t<li class=\"featured-clinical-evidence-item\" role=\"listitem\" aria-labelledby=\"post-title-6528\" aria-describedby=\"post-category-6528 post-excerpt-6528\">\n\t\t\t\t\t<div class=\"featured-clinical-evidence-item--text-container\" id=\"post-title-6528\">\n\t\t\t\t\t\t<a href=\"https:\/\/shockwavemedical.com\/de\/clinical-evidence\/pad-iii-os\/\" class=\"featured-clinical-evidence-item--title\">\n\t\t\t\t\t\t\tDISRUPT PAD III Observational Study\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"featured-clinical-evidence-item--arrow\" aria-hidden=\"true\"><svg width=\"25\" height=\"27\" viewBox=\"0 0 25 27\" fill=\"none\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M3.5 26H21a2.5 2.5 0 002.5-2.5V7.875L16.625 1H6a2.5 2.5 0 00-2.5 2.5v3.75\" stroke=\"#5B6770\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\"\/><path d=\"M16 1v7.5h7.5M4.75 19.75a3.75 3.75 0 100-7.498 3.75 3.75 0 000 7.498v0zm5 1.25l-1.875-1.875\" stroke=\"#5B6770\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\"\/><\/svg><\/div>\n\t\t\t\t\t\t<div class=\"featured-clinical-evidence-item--arrow-hover\" aria-hidden=\"true\"><svg width=\"25\" height=\"27\" viewBox=\"0 0 25 27\" fill=\"none\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M3.5 26H21a2.5 2.5 0 002.5-2.5V7.875L16.625 1H6a2.5 2.5 0 00-2.5 2.5v3.75\" stroke=\"#00D2FF\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\"\/><path d=\"M16 1v7.5h7.5M4.75 19.75a3.75 3.75 0 100-7.498 3.75 3.75 0 000 7.498v0zm5 1.25l-1.875-1.875\" stroke=\"#00D2FF\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\"\/><\/svg><\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t<div class=\"featured-clinical-evidence-item--excerpt\" id=\"post-excerpt-6528\">\n\t\t\t\t\t\tThe largest prospective real-world evidence for the treatment of complex, heavily calcified peripheral arterial disease (PAD).\t\t\t\t\t<\/div>\n\t\t\t\t\t<div class=\"featured-clinical-evidence-item--category\" id=\"post-category-6528\">\n\t\t\t\t\t\tPeripheral IVL\t\t\t\t\t<\/div>\n\t\t\t\t<\/li>\n\t\t\t<\/ul>\n<\/section>\n\n\n<section\n\tid=\"block_41d3bcb93e9334b463a2405c965d7ded\"\n\tclass=\"block block--spacer-with-optional-divider \"\n\taria-label=\"Spacer section with optional divider\">\n\t<div class=\"spacer-with-optional-divider-container container\">\n\n\t\t<!-- Space Above -->\n\t\t<div\n\t\t\tclass=\"space-above\"\n\t\t\tstyle=\"--aboveDesktop: 60px; --aboveMobile: 30px;\"\n\t\t\taria-hidden=\"true\"\n\t\t\trole=\"presentation\">\n\t\t<\/div>\n\n\t\t<!-- Optional Divider -->\n\t\t\n\t\t<!-- Space Below -->\n\t\t<div\n\t\t\tclass=\"space-below\"\n\t\t\tstyle=\"--belowDesktop: 0px; --belowMobile: 0px;\"\n\t\t\taria-hidden=\"true\"\n\t\t\trole=\"presentation\">\n\t\t<\/div>\n\n\t<\/div>\n<\/section>\n\n\n<section id=\"block_3d22c0eea55847181e5a7441c770ca76\" class=\"block block--wysiwyg wysiwyg_styles u-bgColorNone container\">\n\t<div class=\"u-wysiwyg u-animation\">\n\t\t<p><span class=\"legal_copy\">Chandra V, Lansky AJ, Sayfo S, et al. Thirty-Day Outcomes from the Disrupt PAD BTK II Study of the Shockwave Intravascular Lithotripsy System for Treatment of Calcified Below-the-Knee Peripheral Arterial Disease. Journal of Vascular Surgery. Published online November 12, 2024. doi:10.1016\/j.jvs.2024.11.003<\/span><\/p>\n\t<\/div>\n\t<\/section>\n\n<section\n\tid=\"block_41d3bcb93e9334b463a2405c965d7ded\"\n\tclass=\"block block--spacer-with-optional-divider \"\n\taria-label=\"Spacer section with optional divider\">\n\t<div class=\"spacer-with-optional-divider-container container\">\n\n\t\t<!-- Space Above -->\n\t\t<div\n\t\t\tclass=\"space-above\"\n\t\t\tstyle=\"--aboveDesktop: 60px; --aboveMobile: 30px;\"\n\t\t\taria-hidden=\"true\"\n\t\t\trole=\"presentation\">\n\t\t<\/div>\n\n\t\t<!-- Optional Divider -->\n\t\t\n\t\t<!-- Space Below -->\n\t\t<div\n\t\t\tclass=\"space-below\"\n\t\t\tstyle=\"--belowDesktop: 0px; --belowMobile: 0px;\"\n\t\t\taria-hidden=\"true\"\n\t\t\trole=\"presentation\">\n\t\t<\/div>\n\n\t<\/div>\n<\/section>","protected":false},"excerpt":{"rendered":"<p>Global prospective, multi-center, single-arm  study assessing the safety and effectiveness of Shockwave peripheral IVL in treating long, calcified BTK lesions. <\/p>\n","protected":false},"featured_media":4001,"template":"","format":[],"meta":{"_acf_changed":true,"content-type":""},"disease-state":[153,169],"product-tag":[285,293],"specialty":[297,330,334,338,346],"technology":[326],"class_list":["post-6687","clinical-evidence","type-clinical-evidence","status-publish","has-post-thumbnail","hentry","disease-state-below-the-knee-btk-de","disease-state-peripheral-artery-disease-de","product-tag-shockwave-m5-de","product-tag-shockwave-s4-de","specialty-fellows-residents-de","specialty-interventional-cardiologists-de","specialty-interventional-radiologists-de","specialty-nurses-technologists-de","specialty-vascular-surgeons-de","technology-peripheral-ivl-de"],"acf":[],"_links":{"self":[{"href":"https:\/\/shockwavemedical.com\/de\/wp-json\/wp\/v2\/clinical-evidence\/6687","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/shockwavemedical.com\/de\/wp-json\/wp\/v2\/clinical-evidence"}],"about":[{"href":"https:\/\/shockwavemedical.com\/de\/wp-json\/wp\/v2\/types\/clinical-evidence"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/shockwavemedical.com\/de\/wp-json\/wp\/v2\/media\/4001"}],"wp:attachment":[{"href":"https:\/\/shockwavemedical.com\/de\/wp-json\/wp\/v2\/media?parent=6687"}],"wp:term":[{"taxonomy":"disease-state","embeddable":true,"href":"https:\/\/shockwavemedical.com\/de\/wp-json\/wp\/v2\/disease-state?post=6687"},{"taxonomy":"format","embeddable":true,"href":"https:\/\/shockwavemedical.com\/de\/wp-json\/wp\/v2\/format?post=6687"},{"taxonomy":"product-tag","embeddable":true,"href":"https:\/\/shockwavemedical.com\/de\/wp-json\/wp\/v2\/product-tag?post=6687"},{"taxonomy":"specialty","embeddable":true,"href":"https:\/\/shockwavemedical.com\/de\/wp-json\/wp\/v2\/specialty?post=6687"},{"taxonomy":"technology","embeddable":true,"href":"https:\/\/shockwavemedical.com\/de\/wp-json\/wp\/v2\/technology?post=6687"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}