{"id":3702,"date":"2021-06-17T20:02:37","date_gmt":"2021-06-18T01:02:37","guid":{"rendered":"https:\/\/shockwavemedical.com\/sound-science-yields-vessel-compliance-dr-ziad-ali-explains-the-unique-moa-of-ivl\/"},"modified":"2024-12-09T12:58:09","modified_gmt":"2024-12-09T18:58:09","slug":"ziad-ali-ivl-mechanism-of-action","status":"publish","type":"post","link":"https:\/\/shockwavemedical.com\/de\/education\/ziad-ali-ivl-mechanism-of-action\/","title":{"rendered":"Sound Science Yields Vessel Compliance: Dr. Ziad Ali Explains the Unique MOA of IVL"},"content":{"rendered":"\n<section id=\"block_27bd51145206a60c171cfeaa4a9aa299\" class=\"block block--wysiwyg wysiwyg_styles u-bgColorNone container\">\n\t<div class=\"u-wysiwyg u-animation\">\n\t\t<p>\u201cI think this is going to work!\u201d<\/p>\n<p>Join Dr. Ziad Ali as he steps us through the invention and principles of IVL: from leveraging the concepts of extracorporeal lithotripsy in the initial experiments to cracking egg shells to a matured, miniaturized device able to fracture intravascular calcium. Gain insights on the 5 mechanical forces of a shockwave working together to create circumferential, transverse, and longitudinal calcium fractures that impact both superficial and deep layers of the vessel. Hear how safety was paramount in designing IVL and why it\u2019s become an important tool in the calcium modification toolbox.<\/p>\n<div class=\"video\"><iframe title=\"YouTube video player\" data-src=\"https:\/\/www.youtube.com\/embed\/TIA51ZQXDI4?si=nAVzBOotV3up7CTu\" frameborder=\"0\" allowfullscreen=\"allowfullscreen\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" class=\"lazyload\" data-load-mode=\"1\"><\/iframe><\/div>\n<hr \/>\n<p><span class=\"legal_copy\"><strong>Important Safety Information<\/strong> <\/span><\/p>\n<p><span class=\"legal_copy\">Please contact your local Shockwave representative for specific country availability and refer to the Shockwave C2, Shockwave S4, and Shockwave M5 instructions for use containing important safety information. <\/span><\/p>\n<p><span class=\"legal_copy\"><strong>CORONARY ISI:<\/strong> <\/span><\/p>\n<p><span class=\"legal_copy\">Rx only <\/span><\/p>\n<p><span class=\"legal_copy\">Indications for Use\u2014The Shockwave Intravascular Lithotripsy (IVL) System with the Shockwave C2 Coronary IVL Catheter is indicated for lithotripsy enabled, low-pressure balloon dilatation of severely calcified, stenotic de novo coronary arteries prior to stenting. <\/span><\/p>\n<p><span class=\"legal_copy\">Contraindications\u2014The Shockwave C2 Coronary IVL System is contraindicated for the following: This device is not intended for stent delivery. This device is not intended for use in carotid or cerebrovascular arteries. <\/span><\/p>\n<p><span class=\"legal_copy\">Warnings\u2014 Use the IVL Generator in accordance with recommended settings as stated in the Operator\u2019s Manual. The risk of a dissection or perforation is increased in severely calcified lesions undergoing percutaneous treatment, including IVL. Appropriate provisional interventions should be readily available. Balloon loss of pressure was associated with a numerical increase in dissection which was not statistically significant and was not associated with MACE. Analysis indicates calcium length is a predictor of dissection and balloon loss of pressure. IVL generates mechanical pulses which may cause atrial or ventricular capture in bradycardic patients. In patients with implantable pacemakers and defibrillators, the asynchronous capture may interact with the sensing capabilities. Monitoring of the electrocardiographic rhythm and continuous arterial pressure during IVL treatment is required. In the event of clinically significant hemodynamic effects, temporarily cease delivery of IVL therapy. <\/span><\/p>\n<p><span class=\"legal_copy\">Precautions\u2014 Only to be used by physicians trained in angiography and intravascular coronary procedures. Use only the recommended balloon inflation medium. Hydrophilic coating to be wet only with normal saline or water and care must be taken with sharp objects to avoid damage to the hydrophilic coating. Appropriate anticoagulant therapy should be administered by the physician. Precaution should be taken when treating patients with previous stenting within 5mm of target lesion. <\/span><\/p>\n<p><span class=\"legal_copy\">Potential adverse effects consistent with standard based cardiac interventions include\u2013 Abrupt vessel closure \u2013 Allergic reaction to contrast medium, anticoagulant and\/or antithrombotic therapy-Aneurysm-Arrhythmia-Arteriovenous fistula-Bleeding complications-Cardiac tamponade or pericardial effusion-Cardiopulmonary arrest-Cerebrovascular accident (CVA)-Coronary artery\/vessel occlusion, perforation, rupture or dissection-Coronary artery spasm-Death-Emboli (air, tissue, thrombus or atherosclerotic emboli)-Emergency or non-emergency coronary artery bypass surgery-Emergency or non-emergency percutaneous coronary intervention-Entry site complications-Fracture of the guide wire or failure\/malfunction of any component of the device that may or may not lead to device embolism, dissection, serious injury or surgical intervention-Hematoma at the vascular access site(s)- Hemorrhage-Hypertension\/Hypotension-Infection\/sepsis\/fever-Myocardial Infarction-Myocardial Ischemia or unstable angina-Pain-Peripheral Ischemia- Pseudoaneurysm-Renal failure\/insufficiency-Restenosis of the treated coronary artery leading to revascularization-Shock\/pulmonary edema-Slow flow, no reflow, or abrupt closure of coronary artery-Stroke-Thrombus-Vessel closure, abrupt-Vessel injury requiring surgical repair-Vessel dissection, perforation, rupture, or spasm. <\/span><\/p>\n<p><span class=\"legal_copy\">Risks identified as related to the device and its use: Allergic\/immunologic reaction to the catheter material(s) or coating-Device malfunction, failure, or balloon loss of pressure leading to device embolism, dissection, serious injury or surgical intervention-Atrial or ventricular extrasystole-Atrial or ventricular capture. <\/span><\/p>\n<p><span class=\"legal_copy\">Prior to use, please reference the Instructions for Use for more information on warnings, precautions and adverse events. https:\/\/shockwavemedical.com\/IFU <\/span><\/p>\n<p><span class=\"legal_copy\">Please contact your local Shockwave representative for specific country availability and refer to the Shockwave C2 instructions for use containing important safety information. <\/span><\/p>\n<p><span class=\"legal_copy\"><strong>PERIPHERAL ISI:<\/strong> <\/span><\/p>\n<p><span class=\"legal_copy\">Caution: Federal law (USA) restricts this device to sale by or on the order of a physician. <\/span><\/p>\n<p><span class=\"legal_copy\">Indication for Use \u2013 The Shockwave Medical Intravascular Lithotripsy (IVL) System is intended for lithotripsy-enhanced balloon dilatation of lesions, including calcified lesions, in the peripheral vasculature, including the iliac, femoral, ilio-femoral, popliteal, infra-popliteal, and renal arteries. Not for use in the coronary or cerebral vasculature. <\/span><\/p>\n<p><span class=\"legal_copy\">Contraindications \u2013 Do not use if unable to pass 0.014 guidewire across the lesion \u2022 Not intended for treatment of in-stent restenosis or in coronary, carotid, or cerebrovascular arteries. <\/span><\/p>\n<p><span class=\"legal_copy\">Warnings \u2013 Only to be used by physicians who are familiar with interventional vascular procedures \u2022 Physicians must be trained prior to use of the device \u2022 Use the Generator in accordance with recommended settings as stated in the Operator\u2019s Manual <\/span><\/p>\n<p><span class=\"legal_copy\">Precautions \u2013 Use only the recommended balloon inflation medium \u2022 Appropriate anticoagulant therapy should be administered by the physician \u2022 Decision regarding use of distal protection should be made based on physician assessment of treatment lesion morphology <\/span><\/p>\n<p><span class=\"legal_copy\">Adverse Effects \u2013 Possible adverse effects consistent with standard angioplasty include: \u2022 Access site complications \u2022 Allergy to contrast or blood thinners \u2022 Arterial bypass surgery \u2022 Bleeding complications \u2022 Death \u2022 Fracture of guidewire or device \u2022 Hypertension\/Hypotension \u2022 Infection\/sepsis \u2022 Placement of a stent \u2022 Renal failure \u2022 Shock\/pulmonary edema \u2022 Target vessel stenosis or occlusion \u2022 Vascular complications. Risks unique to the device and its use: \u2022 Allergy to catheter material(s) \u2022 Device malfunction or failure \u2022 Excess heat at target site <\/span><\/p>\n<p><span class=\"legal_copy\">Prior to use, please reference the Instructions for Use for more information on indications, contraindications, warnings, precautions, and adverse events. www.shockwavemedical.com <\/span><\/p>\n<p><span class=\"legal_copy\">Please contact your local Shockwave representative for specific country availability and refer to the Shockwave M5 and Shockwave S4 instructions for use containing important safety information.<\/span><\/p>\n\t<\/div>\n\t<\/section>","protected":false},"excerpt":{"rendered":"<p>Dr. Ziad Ali Explains the Unique Mechanism of Action (MOA) of Shockwave IVL Intravascular Lithotripsy<\/p>\n","protected":false},"author":2,"featured_media":8648,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":[207,210],"meta":{"_acf_changed":true,"content-type":"","footnotes":""},"categories":[3],"tags":[],"disease-state":[161,169],"education-topic":[185,193],"product-tag":[],"specialty":[330,346],"technology":[318,326],"class_list":["post-3702","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-unkategorisiert","disease-state-coronary-artery-disease-de","disease-state-peripheral-artery-disease-de","education-topic-best-practices-de","education-topic-mechanism-of-action-moa-de","format-article-de","format-video-de","specialty-interventional-cardiologists-de","specialty-vascular-surgeons-de","technology-coronary-ivl-de","technology-peripheral-ivl-de"],"acf":[],"_links":{"self":[{"href":"https:\/\/shockwavemedical.com\/de\/wp-json\/wp\/v2\/posts\/3702","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/shockwavemedical.com\/de\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/shockwavemedical.com\/de\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/shockwavemedical.com\/de\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/shockwavemedical.com\/de\/wp-json\/wp\/v2\/comments?post=3702"}],"version-history":[{"count":0,"href":"https:\/\/shockwavemedical.com\/de\/wp-json\/wp\/v2\/posts\/3702\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/shockwavemedical.com\/de\/wp-json\/wp\/v2\/media\/8648"}],"wp:attachment":[{"href":"https:\/\/shockwavemedical.com\/de\/wp-json\/wp\/v2\/media?parent=3702"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/shockwavemedical.com\/de\/wp-json\/wp\/v2\/categories?post=3702"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/shockwavemedical.com\/de\/wp-json\/wp\/v2\/tags?post=3702"},{"taxonomy":"disease-state","embeddable":true,"href":"https:\/\/shockwavemedical.com\/de\/wp-json\/wp\/v2\/disease-state?post=3702"},{"taxonomy":"education-topic","embeddable":true,"href":"https:\/\/shockwavemedical.com\/de\/wp-json\/wp\/v2\/education-topic?post=3702"},{"taxonomy":"format","embeddable":true,"href":"https:\/\/shockwavemedical.com\/de\/wp-json\/wp\/v2\/format?post=3702"},{"taxonomy":"product-tag","embeddable":true,"href":"https:\/\/shockwavemedical.com\/de\/wp-json\/wp\/v2\/product-tag?post=3702"},{"taxonomy":"specialty","embeddable":true,"href":"https:\/\/shockwavemedical.com\/de\/wp-json\/wp\/v2\/specialty?post=3702"},{"taxonomy":"technology","embeddable":true,"href":"https:\/\/shockwavemedical.com\/de\/wp-json\/wp\/v2\/technology?post=3702"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}