{"id":6527,"date":"2022-11-01T15:43:00","date_gmt":"2022-11-01T20:43:00","guid":{"rendered":"https:\/\/shockwavemedical.com\/clinical-evidence\/disrupt-pad-iii-observational-study\/"},"modified":"2026-04-08T08:05:25","modified_gmt":"2026-04-08T13:05:25","slug":"pad-iii-os","status":"publish","type":"clinical-evidence","link":"https:\/\/shockwavemedical.com\/en-eu\/clinical-evidence\/pad-iii-os\/","title":{"rendered":"DISRUPT PAD III Observational Study"},"content":{"rendered":"\n\n\n<section id=\"block_92e0dddeb39c195fa9bfa01b528042c9\" class=\"block block--primary-header u-darkMode u-bgColor_primary shockwave\"\n\tstyle=\"--desktop-bg-image: url('https:\/\/shockwavemedical.com\/wp-content\/uploads\/2024\/11\/Background-Pulses.png');\n\t\t\t\t --mobile-bg-image: url('');\">\n\n\t<div class=\"primary-header-container text_colors\">\n\n\t\t<!-- Heading -->\n\t\t<div class=\"heading\">\n\t\t\t<h1 class=\"main-heading\">DISRUPT PAD III Observational Study <\/h1>\n\t\t\t<h3 class=\"sub-heading\">Count on it: The DISRUPT PAD III Observational Study (OS) is the largest prospective real-world evidence for the treatment of complex, heavily calcified peripheral artery disease (PAD).<\/h3>\n\t\t<\/div>\n\n\t\t<!-- Optional links -->\n\t\t\n\t\t<!-- links - J&J -->\n\t\t\n\t\t<!-- Social share -->\n\t\t\t\t<!-- Foreground for Desktop -->\n\t\t\t\t\t<div class=\"desktop-foreground-file\">\n\t\t\t\t\t\t\t\t\t<img decoding=\"async\" data-src=\"https:\/\/shockwavemedical.com\/wp-content\/uploads\/2024\/11\/DISRUPT-PAD-III-Clinical-Hero-Image-13.png\" alt=\"DISRUPT PAD III OS logo\" role=\"img\" aria-label=\"Foreground image for desktop\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" class=\"lazyload\" style=\"--smush-placeholder-width: 955px; --smush-placeholder-aspect-ratio: 955\/970;\">\n\t\t\t\t\t\t\t<\/div>\n\t\t\n\t\t<!-- Foreground for Mobile -->\n\t\t\t\t\t<div class=\"mobile-foreground-file\">\n\t\t\t\t\t\t\t\t\t<img decoding=\"async\" data-src=\"https:\/\/shockwavemedical.com\/wp-content\/uploads\/2024\/11\/Clinical-Hero-Images-mobile-12.png\" alt=\"DISRUPT PAD III Observational Study logo\" role=\"img\" aria-label=\"Foreground image for mobile\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" class=\"lazyload\" style=\"--smush-placeholder-width: 814px; --smush-placeholder-aspect-ratio: 814\/450;\">\n\t\t\t\t\t\t\t<\/div>\n\t\t\t<\/div>\n<\/section>\n\n\n<section id=\"findings\" class=\"block block--content-3-or-4-up text_colors \" aria-labelledby=\"section-heading-findings\">\n\t<div class=\"container\">\n\n\t\t<!-- Header -->\n\t\t\t\t\t<header class=\"heading-row\">\n\t\t\t\t\t\t\t\t\t<h2 id=\"section-heading-findings\" class=\"optional-heading\">\n\t\t\t\t\t\tKey Findings\t\t\t\t\t<\/h2>\n\t\t\t\t\n\t\t\t\t\t\t\t<\/header>\n\t\t\n\t\t<!-- Cards Section -->\n\t\t<ul class=\"cards three-cards\" role=\"list\">\n\t\t\t\t\t\t\t<li class=\"card content-3-or-4-up-card three-cards\" role=\"listitem\">\n\t\t\t\t\t\n\t\t\t\t\t<!-- Card Content -->\n\t\t\t\t\t<div class=\"card-heading-description-link\">\n\t\t\t\t\t\t<h3 class=\"card-heading\">Predictable Outcomes in Challenging Situations<\/h3>\n\n\t\t\t\t\t\t<div class=\"card-description-link\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"card-description small_body\">DISRUPT PAD III OS saw predictably consistent results across vessel beds, challenging lesions and complex patients.<\/div>\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/li>\n\t\t\t\t\t\t\t<li class=\"card content-3-or-4-up-card three-cards\" role=\"listitem\">\n\t\t\t\t\t\n\t\t\t\t\t<!-- Card Content -->\n\t\t\t\t\t<div class=\"card-heading-description-link\">\n\t\t\t\t\t\t<h3 class=\"card-heading\">Real-world Outcomes Consistent with Randomized Trial<\/h3>\n\n\t\t\t\t\t\t<div class=\"card-description-link\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"card-description small_body\">Shockwave IVL safely and effectively modifies calcium across multiple vessel beds.<\/div>\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/li>\n\t\t\t\t\t\t\t<li class=\"card content-3-or-4-up-card three-cards\" role=\"listitem\">\n\t\t\t\t\t\n\t\t\t\t\t<!-- Card Content -->\n\t\t\t\t\t<div class=\"card-heading-description-link\">\n\t\t\t\t\t\t<h3 class=\"card-heading\">Optimized Procedural Insights<\/h3>\n\n\t\t\t\t\t\t<div class=\"card-description-link\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"card-description small_body\">The use of embolic protection was less when IVL was used as the only calcium modification tool; IVL saw better results with appropriate IVL sizing (oversizing 10%).<\/div>\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/li>\n\t\t\t\t\t<\/ul>\n\t<\/div>\n<\/section>\n\n<section\n\tid=\"block_79e6a7b1ab0f7b6819942f8b605035d9\"\n\tclass=\"block block--spacer-with-optional-divider \"\n\taria-label=\"Spacer section with optional divider\">\n\t<div class=\"spacer-with-optional-divider-container container\">\n\n\t\t<!-- Space Above -->\n\t\t<div\n\t\t\tclass=\"space-above\"\n\t\t\tstyle=\"--aboveDesktop: 30px; --aboveMobile: 20px;\"\n\t\t\taria-hidden=\"true\"\n\t\t\trole=\"presentation\">\n\t\t<\/div>\n\n\t\t<!-- Optional Divider -->\n\t\t\n\t\t<!-- Space Below -->\n\t\t<div\n\t\t\tclass=\"space-below\"\n\t\t\tstyle=\"--belowDesktop: 0px; --belowMobile: 0px;\"\n\t\t\taria-hidden=\"true\"\n\t\t\trole=\"presentation\">\n\t\t<\/div>\n\n\t<\/div>\n<\/section>\n\n\n<section id=\"design\" class=\"block block--study-design-patient-chars shockwave\" role=\"region\" aria-labelledby=\"design-heading\">\n\t<div class=\"container\">\n\t\t\t\t\t<div class=\"heading-row wysiwyg_styles\">\n\t\t\t\t\t\t\t\t\t<h2 id=\"design-heading\" class=\"heading\">\n\t\t\t\t\t\tStudy Design & Characteristics\t\t\t\t\t<\/h2>\n\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"columns wysiwyg_styles\" aria-label=\"Study Design Columns\">\n\t\t\t<div class=\"columns-2-and-3\">\n\t\t\t\t<div class=\"column-2\">\n\t\t\t\t\t<p><strong>Objective: <\/strong><\/p>\n<p>Assess real-world peri-procedural outcomes of Shockwave Intravascular Lithotripsy (IVL) for the treatment of calcified, stenotic peripheral arteries<\/p>\n<p><strong>Design: <\/strong><\/p>\n<ul>\n<li>Prospective<\/li>\n<li>Multicenter<\/li>\n<li>Single-blind<\/li>\n<li>Observational study<\/li>\n<\/ul>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"column-3\">\n\t\t\t\t\t<p><strong>Key Inclusion Criteria:<\/strong><\/p>\n<ul>\n<li>Rutherford classification 2-6<\/li>\n<li>Moderate-severe calcification*<\/li>\n<li>Ilio-femoral, femoral, popliteal and infrapopliteal arteries<\/li>\n<\/ul>\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t<div class=\"column-1\">\n\t\t\t\t<div class=\"column-1-content\">\n\t\t\t\t\t<div class=\"column-1-content-top\">\n\t\t\t\t\t\tComplex real-world patients & lesions\t\t\t\t\t<\/div>\n\t\t\t\t\t<div class=\"column-1-content-bottom\">\n\t\t\t\t\t\tResults reinforce the predictability of Shockwave IVL & its ability to consistently modify calcium across vessel beds, challenging lesions & complex patients (CLTI, dialysis & female patients)\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"column-1-arrow\" aria-hidden=\"true\" aria-label=\"Arrow pointing downwards to indicate result\"><i class=\"fa-regular fa-arrow-down\"><\/i><\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t<\/div>\n<\/section>\n\n<section\n\tid=\"block_885ad7cc909aa46f58daf21782aa8077\"\n\tclass=\"block block--spacer-with-optional-divider \"\n\taria-label=\"Spacer section with optional divider\">\n\t<div class=\"spacer-with-optional-divider-container container\">\n\n\t\t<!-- Space Above -->\n\t\t<div\n\t\t\tclass=\"space-above\"\n\t\t\tstyle=\"--aboveDesktop: 60px; --aboveMobile: 30px;\"\n\t\t\taria-hidden=\"true\"\n\t\t\trole=\"presentation\">\n\t\t<\/div>\n\n\t\t<!-- Optional Divider -->\n\t\t\n\t\t<!-- Space Below -->\n\t\t<div\n\t\t\tclass=\"space-below\"\n\t\t\tstyle=\"--belowDesktop: 0px; --belowMobile: 0px;\"\n\t\t\taria-hidden=\"true\"\n\t\t\trole=\"presentation\">\n\t\t<\/div>\n\n\t<\/div>\n<\/section>\n\n\n<section id=\"block_c37f3ebcc12e1fd836eacff1d3c9f5c8\" class=\"block block--stat-callout shockwave\" role=\"region\" aria-labelledby=\"statCalloutTitle\" aria-describedby=\"statCalloutDesc\">\n\t<h2 id=\"statCalloutTitle\" class=\"sr-only\">Statistics Callout<\/h2> <!-- Add a hidden heading for accessibility -->\n\t<p id=\"statCalloutDesc\" class=\"sr-only\">This section presents key statistical information with numbers and descriptions.<\/p> <!-- Hidden description -->\n\n\t<!-- Changing container to ul for better semantics -->\n\t<ul class=\"container\" role=\"list\">\n\t\t\t\t\t\t<!-- Each card is now an li element for semantic correctness -->\n\t\t\t<li class=\"card\" id=\"block_c37f3ebcc12e1fd836eacff1d3c9f5c8-card-0\" role=\"listitem\" aria-labelledby=\"block_c37f3ebcc12e1fd836eacff1d3c9f5c8-card-0-number\" aria-describedby=\"block_c37f3ebcc12e1fd836eacff1d3c9f5c8-card-0-description\">\n\t\t\t\t<div class=\"card-top\">\n\t\t\t\t\t\t\t\t\t\t\t<div class=\"card-number\" id=\"block_c37f3ebcc12e1fd836eacff1d3c9f5c8-card-0-number\">1,373<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"card-symbol\">\n\t\t\t\t\t\t\t<span><\/span>\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t\t\t<div class=\"card-description font--p\" id=\"block_c37f3ebcc12e1fd836eacff1d3c9f5c8-card-0-description\">\n\t\t\t\t\t\tComplex real-world patients\t\t\t\t\t<\/div>\n\t\t\t\t\n\t\t\t<\/li>\n\t\t\t\t\t<!-- Each card is now an li element for semantic correctness -->\n\t\t\t<li class=\"card\" id=\"block_c37f3ebcc12e1fd836eacff1d3c9f5c8-card-1\" role=\"listitem\" aria-labelledby=\"block_c37f3ebcc12e1fd836eacff1d3c9f5c8-card-1-number\" aria-describedby=\"block_c37f3ebcc12e1fd836eacff1d3c9f5c8-card-1-description\">\n\t\t\t\t<div class=\"card-top\">\n\t\t\t\t\t\t\t\t\t\t\t<div class=\"card-number\" id=\"block_c37f3ebcc12e1fd836eacff1d3c9f5c8-card-1-number\">36<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"card-symbol\">\n\t\t\t\t\t\t\t<span>%<\/span>\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t\t\t<div class=\"card-description font--p\" id=\"block_c37f3ebcc12e1fd836eacff1d3c9f5c8-card-1-description\">\n\t\t\t\t\t\tChronic limb-threatening ischemia (CLTI) patients\t\t\t\t\t<\/div>\n\t\t\t\t\n\t\t\t<\/li>\n\t\t\t\t\t<!-- Each card is now an li element for semantic correctness -->\n\t\t\t<li class=\"card\" id=\"block_c37f3ebcc12e1fd836eacff1d3c9f5c8-card-2\" role=\"listitem\" aria-labelledby=\"block_c37f3ebcc12e1fd836eacff1d3c9f5c8-card-2-number\" aria-describedby=\"block_c37f3ebcc12e1fd836eacff1d3c9f5c8-card-2-description\">\n\t\t\t\t<div class=\"card-top\">\n\t\t\t\t\t\t\t\t\t\t\t<div class=\"card-number\" id=\"block_c37f3ebcc12e1fd836eacff1d3c9f5c8-card-2-number\">56<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"card-symbol\">\n\t\t\t\t\t\t\t<span>%<\/span>\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t\t\t<div class=\"card-description font--p\" id=\"block_c37f3ebcc12e1fd836eacff1d3c9f5c8-card-2-description\">\n\t\t\t\t\t\tDiabetes mellitus\t\t\t\t\t<\/div>\n\t\t\t\t\n\t\t\t<\/li>\n\t\t\t\t\t<!-- Each card is now an li element for semantic correctness -->\n\t\t\t<li class=\"card\" id=\"block_c37f3ebcc12e1fd836eacff1d3c9f5c8-card-3\" role=\"listitem\" aria-labelledby=\"block_c37f3ebcc12e1fd836eacff1d3c9f5c8-card-3-number\" aria-describedby=\"block_c37f3ebcc12e1fd836eacff1d3c9f5c8-card-3-description\">\n\t\t\t\t<div class=\"card-top\">\n\t\t\t\t\t\t\t\t\t\t\t<div class=\"card-number\" id=\"block_c37f3ebcc12e1fd836eacff1d3c9f5c8-card-3-number\">27<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"card-symbol\">\n\t\t\t\t\t\t\t<span>%<\/span>\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t\t\t<div class=\"card-description font--p\" id=\"block_c37f3ebcc12e1fd836eacff1d3c9f5c8-card-3-description\">\n\t\t\t\t\t\tRenal deficiency\t\t\t\t\t<\/div>\n\t\t\t\t\n\t\t\t<\/li>\n\t\t\t\t\t<!-- Each card is now an li element for semantic correctness -->\n\t\t\t<li class=\"card\" id=\"block_c37f3ebcc12e1fd836eacff1d3c9f5c8-card-4\" role=\"listitem\" aria-labelledby=\"block_c37f3ebcc12e1fd836eacff1d3c9f5c8-card-4-number\" aria-describedby=\"block_c37f3ebcc12e1fd836eacff1d3c9f5c8-card-4-description\">\n\t\t\t\t<div class=\"card-top\">\n\t\t\t\t\t\t\t\t\t\t\t<div class=\"card-number\" id=\"block_c37f3ebcc12e1fd836eacff1d3c9f5c8-card-4-number\">1,531<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"card-symbol\">\n\t\t\t\t\t\t\t<span><\/span>\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t\t\t<div class=\"card-description font--p\" id=\"block_c37f3ebcc12e1fd836eacff1d3c9f5c8-card-4-description\">\n\t\t\t\t\t\tChallenging lesions\t\t\t\t\t<\/div>\n\t\t\t\t\n\t\t\t<\/li>\n\t\t\t\t\t<!-- Each card is now an li element for semantic correctness -->\n\t\t\t<li class=\"card\" id=\"block_c37f3ebcc12e1fd836eacff1d3c9f5c8-card-5\" role=\"listitem\" aria-labelledby=\"block_c37f3ebcc12e1fd836eacff1d3c9f5c8-card-5-number\" aria-describedby=\"block_c37f3ebcc12e1fd836eacff1d3c9f5c8-card-5-description\">\n\t\t\t\t<div class=\"card-top\">\n\t\t\t\t\t\t\t\t\t\t\t<div class=\"card-number\" id=\"block_c37f3ebcc12e1fd836eacff1d3c9f5c8-card-5-number\">90<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"card-symbol\">\n\t\t\t\t\t\t\t<span>%<\/span>\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t\t\t<div class=\"card-description font--p\" id=\"block_c37f3ebcc12e1fd836eacff1d3c9f5c8-card-5-description\">\n\t\t\t\t\t\tModerate-severe calcium**\t\t\t\t\t<\/div>\n\t\t\t\t\n\t\t\t<\/li>\n\t\t\t\t\t<!-- Each card is now an li element for semantic correctness -->\n\t\t\t<li class=\"card\" id=\"block_c37f3ebcc12e1fd836eacff1d3c9f5c8-card-6\" role=\"listitem\" aria-labelledby=\"block_c37f3ebcc12e1fd836eacff1d3c9f5c8-card-6-number\" aria-describedby=\"block_c37f3ebcc12e1fd836eacff1d3c9f5c8-card-6-description\">\n\t\t\t\t<div class=\"card-top\">\n\t\t\t\t\t\t\t\t\t\t\t<div class=\"card-number\" id=\"block_c37f3ebcc12e1fd836eacff1d3c9f5c8-card-6-number\">115<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"card-symbol\">\n\t\t\t\t\t\t\t<span>mm<\/span>\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t\t\t<div class=\"card-description font--p\" id=\"block_c37f3ebcc12e1fd836eacff1d3c9f5c8-card-6-description\">\n\t\t\t\t\t\tAverage calcified length\t\t\t\t\t<\/div>\n\t\t\t\t\n\t\t\t<\/li>\n\t\t\t\t\t<!-- Each card is now an li element for semantic correctness -->\n\t\t\t<li class=\"card\" id=\"block_c37f3ebcc12e1fd836eacff1d3c9f5c8-card-7\" role=\"listitem\" aria-labelledby=\"block_c37f3ebcc12e1fd836eacff1d3c9f5c8-card-7-number\" aria-describedby=\"block_c37f3ebcc12e1fd836eacff1d3c9f5c8-card-7-description\">\n\t\t\t\t<div class=\"card-top\">\n\t\t\t\t\t\t\t\t\t\t\t<div class=\"card-number\" id=\"block_c37f3ebcc12e1fd836eacff1d3c9f5c8-card-7-number\">31<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"card-symbol\">\n\t\t\t\t\t\t\t<span>%<\/span>\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t\t\t<div class=\"card-description font--p\" id=\"block_c37f3ebcc12e1fd836eacff1d3c9f5c8-card-7-description\">\n\t\t\t\t\t\tChronic total occlusions (CTO)\t\t\t\t\t<\/div>\n\t\t\t\t\n\t\t\t<\/li>\n\t\t\t\t<\/ul>\n<\/section>\n\n<section\n\tid=\"results\"\n\tclass=\"block block--spacer-with-optional-divider \"\n\taria-label=\"Spacer section with optional divider\">\n\t<div class=\"spacer-with-optional-divider-container container\">\n\n\t\t<!-- Space Above -->\n\t\t<div\n\t\t\tclass=\"space-above\"\n\t\t\tstyle=\"--aboveDesktop: 60px; --aboveMobile: 30px;\"\n\t\t\taria-hidden=\"true\"\n\t\t\trole=\"presentation\">\n\t\t<\/div>\n\n\t\t<!-- Optional Divider -->\n\t\t\n\t\t<!-- Space Below -->\n\t\t<div\n\t\t\tclass=\"space-below\"\n\t\t\tstyle=\"--belowDesktop: 0px; --belowMobile: 0px;\"\n\t\t\taria-hidden=\"true\"\n\t\t\trole=\"presentation\">\n\t\t<\/div>\n\n\t<\/div>\n<\/section>\n\n\n<section id=\"block_841168ebee7d2b11510d44bfd59cef9e\" class=\"block block--wysiwyg wysiwyg_styles u-bgColorNone shockwave container\">\n\t<div class=\"u-wysiwyg u-animation\">\n\t\t<h2>Predictable Outcomes in Challenging Situations<\/h2>\n<p>DISRUPT PAD III OS saw predictably consistent results across vessel beds, challenging lesions and complex patients.<\/p>\n<h3 style=\"text-align: center;\">Majority of Stenosis Reduction Seen from IVL Treatment<\/h3>\n<p><img decoding=\"async\" class=\"aligncenter wp-image-6420 lazyload\" data-src=\"https:\/\/shockwavemedical.com\/wp-content\/uploads\/2024\/11\/Disrupt_PAD_III_OS_Global_White_1-300x145.png\" alt=\"Bar chart showing diameter stenosis percentages across various categories before the procedure (Pre-procedure), after Intravascular Lithotripsy (Post-IVL), and at the final measurement (Final). The chart is divided into three main sections: 'Vessel Beds,' 'Challenging Lesions,' and 'Complex Patients.'\" width=\"1600\" height=\"775\" data-srcset=\"https:\/\/shockwavemedical.com\/wp-content\/uploads\/2024\/11\/Disrupt_PAD_III_OS_Global_White_1-300x145.png 300w, https:\/\/shockwavemedical.com\/wp-content\/uploads\/2024\/11\/Disrupt_PAD_III_OS_Global_White_1-1024x496.png 1024w, https:\/\/shockwavemedical.com\/wp-content\/uploads\/2024\/11\/Disrupt_PAD_III_OS_Global_White_1-768x372.png 768w, https:\/\/shockwavemedical.com\/wp-content\/uploads\/2024\/11\/Disrupt_PAD_III_OS_Global_White_1-1536x744.png 1536w, https:\/\/shockwavemedical.com\/wp-content\/uploads\/2024\/11\/Disrupt_PAD_III_OS_Global_White_1.png 2000w\" data-sizes=\"(max-width: 1600px) 100vw, 1600px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 1600px; --smush-placeholder-aspect-ratio: 1600\/775;\" \/><\/p>\n<h2>Real-world Outcomes Consistent with Randomized Trial<\/h2>\n<p>Shockwave IVL safely and effectively modifies calcium across multiple vessel beds.<\/p>\n<h3 style=\"text-align: center;\">Strong Safety Profile<\/h3>\n<table style=\"border-collapse: collapse; width: 100%;\">\n<tbody>\n<tr>\n<td style=\"width: 33.3333%;\"><\/td>\n<td style=\"width: 33.3333%;\">DISRUPT PAD III Randomized Clinical Trial (RCT)<sup>1<\/sup><\/td>\n<td style=\"width: 33.3333%;\">DISRUPT PAD III OS<sup>2<\/sup><\/td>\n<\/tr>\n<tr>\n<td style=\"width: 33.3333%;\"><strong>N<\/strong><\/td>\n<td style=\"width: 33.3333%;\"><strong>153<\/strong><\/td>\n<td style=\"width: 33.3333%;\"><strong>1,367<\/strong><\/td>\n<\/tr>\n<tr>\n<td style=\"width: 33.3333%;\">Vessels<\/td>\n<td style=\"width: 33.3333%;\">Superficial femoral artery (SFA)\/popliteal<\/td>\n<td style=\"width: 33.3333%;\">Iliac, common femoral artery (CFA), SFA\/popliteal, infrapopliteal<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 33.3333%;\">Dissection (Type D-F)<\/td>\n<td style=\"width: 33.3333%;\">0%<\/td>\n<td style=\"width: 33.3333%;\">0.7%<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 33.3333%;\">Perforation<\/td>\n<td style=\"width: 33.3333%;\">0%<\/td>\n<td style=\"width: 33.3333%;\">0.1%<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 33.3333%;\">Embolization<\/td>\n<td style=\"width: 33.3333%;\">0%<\/td>\n<td style=\"width: 33.3333%;\">0%<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 33.3333%;\">Slow flow\/no reflow<\/td>\n<td style=\"width: 33.3333%;\">0%<\/td>\n<td style=\"width: 33.3333%;\">0%<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 33.3333%;\">Abrupt closure<\/td>\n<td style=\"width: 33.3333%;\">0%<\/td>\n<td style=\"width: 33.3333%;\">0%<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 33.3333%;\">Thrombus<\/td>\n<td style=\"width: 33.3333%;\">0%<\/td>\n<td style=\"width: 33.3333%;\">0%<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p style=\"text-align: left;\"><span class=\"legal_copy\">Final angiographic complications (Core-Lab)<\/span><\/p>\n<p>\u00a0<\/p>\n<h3 style=\"text-align: center;\">Proven Effective Calcium Modification<\/h3>\n<p><img decoding=\"async\" class=\"aligncenter wp-image-8199 size-large lazyload\" data-src=\"https:\/\/shockwavemedical.com\/wp-content\/uploads\/2024\/11\/Disrupt_PAD_III_OS_Graph_Updated-1024x634.png\" alt=\"Bar chart showing the reduction in diameter stenosis after Shockwave IVL treatment.\" width=\"1024\" height=\"634\" data-srcset=\"https:\/\/shockwavemedical.com\/wp-content\/uploads\/2024\/11\/Disrupt_PAD_III_OS_Graph_Updated-1024x634.png 1024w, https:\/\/shockwavemedical.com\/wp-content\/uploads\/2024\/11\/Disrupt_PAD_III_OS_Graph_Updated-300x186.png 300w, https:\/\/shockwavemedical.com\/wp-content\/uploads\/2024\/11\/Disrupt_PAD_III_OS_Graph_Updated-768x476.png 768w, https:\/\/shockwavemedical.com\/wp-content\/uploads\/2024\/11\/Disrupt_PAD_III_OS_Graph_Updated-1536x952.png 1536w, https:\/\/shockwavemedical.com\/wp-content\/uploads\/2024\/11\/Disrupt_PAD_III_OS_Graph_Updated.png 2000w\" data-sizes=\"(max-width: 1024px) 100vw, 1024px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 1024px; --smush-placeholder-aspect-ratio: 1024\/634;\" \/><\/p>\n<h2>Shockwave IVL Procedural Insights<\/h2>\n<ul>\n<li>Use of adjunctive technology was at the operator\u2019s discretion<\/li>\n<li>Use of embolic protection was less when Shockwave IVL was used as the only calcium modification tool<\/li>\n<li>Shockwave IVL saw better results with appropriate Shockwave IVL sizing<\/li>\n<\/ul>\n<p>When Shockwave IVL was used as the only calcium modification therapy<sup>\u2020<\/sup>, there was less use of embolic protection.<\/p>\n<p><img decoding=\"async\" class=\"aligncenter wp-image-6430 size-large lazyload\" data-src=\"https:\/\/shockwavemedical.com\/wp-content\/uploads\/2024\/11\/Disrupt_PAD_III_OS_Global_White_2-1024x332.png\" alt=\"A side-by-side comparison of embolic protection rates when IVL (Intravascular Lithotripsy) was used\" width=\"1024\" height=\"332\" data-srcset=\"https:\/\/shockwavemedical.com\/wp-content\/uploads\/2024\/11\/Disrupt_PAD_III_OS_Global_White_2-1024x332.png 1024w, https:\/\/shockwavemedical.com\/wp-content\/uploads\/2024\/11\/Disrupt_PAD_III_OS_Global_White_2-300x97.png 300w, https:\/\/shockwavemedical.com\/wp-content\/uploads\/2024\/11\/Disrupt_PAD_III_OS_Global_White_2-768x249.png 768w, https:\/\/shockwavemedical.com\/wp-content\/uploads\/2024\/11\/Disrupt_PAD_III_OS_Global_White_2-1536x498.png 1536w, https:\/\/shockwavemedical.com\/wp-content\/uploads\/2024\/11\/Disrupt_PAD_III_OS_Global_White_2.png 2000w\" data-sizes=\"(max-width: 1024px) 100vw, 1024px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 1024px; --smush-placeholder-aspect-ratio: 1024\/332;\" \/><\/p>\n<p>\u00a0<\/p>\n<p>Per a multivariable analysis, proper Shockwave IVL balloon sizing (\u2265 1:1)<sup>\u2021<\/sup>\u00a0is an independent predictor of improved stenosis reduction but not a predictor of complications.<\/p>\n<p><img decoding=\"async\" class=\"aligncenter wp-image-6441 size-large lazyload\" data-src=\"https:\/\/shockwavemedical.com\/wp-content\/uploads\/2024\/11\/Disrupt_PAD_III_OS_Global_White_3-1024x133.png\" alt=\"Illustration comparing balloon-to-artery ratio in intravascular procedures.\" width=\"1024\" height=\"133\" data-srcset=\"https:\/\/shockwavemedical.com\/wp-content\/uploads\/2024\/11\/Disrupt_PAD_III_OS_Global_White_3-1024x133.png 1024w, https:\/\/shockwavemedical.com\/wp-content\/uploads\/2024\/11\/Disrupt_PAD_III_OS_Global_White_3-300x39.png 300w, https:\/\/shockwavemedical.com\/wp-content\/uploads\/2024\/11\/Disrupt_PAD_III_OS_Global_White_3-768x99.png 768w, https:\/\/shockwavemedical.com\/wp-content\/uploads\/2024\/11\/Disrupt_PAD_III_OS_Global_White_3-1536x199.png 1536w, https:\/\/shockwavemedical.com\/wp-content\/uploads\/2024\/11\/Disrupt_PAD_III_OS_Global_White_3.png 2000w\" data-sizes=\"(max-width: 1024px) 100vw, 1024px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 1024px; --smush-placeholder-aspect-ratio: 1024\/133;\" \/><\/p>\n\t<\/div>\n\t<\/section>\n\n\n<section id=\"conclusion\" class=\"block block--content-3-or-4-up text_colors \" aria-labelledby=\"section-heading-conclusion\">\n\t<div class=\"container\">\n\n\t\t<!-- Header -->\n\t\t\t\t\t<header class=\"heading-row\">\n\t\t\t\t\t\t\t\t\t<h2 id=\"section-heading-conclusion\" class=\"optional-heading\">\n\t\t\t\t\t\tConclusion\t\t\t\t\t<\/h2>\n\t\t\t\t\n\t\t\t\t\t\t\t<\/header>\n\t\t\n\t\t<!-- Cards Section -->\n\t\t<ul class=\"cards \" role=\"list\">\n\t\t\t\t\t\t\t<li class=\"card content-3-or-4-up-card \" role=\"listitem\">\n\t\t\t\t\t\n\t\t\t\t\t<!-- Card Content -->\n\t\t\t\t\t<div class=\"card-heading-description-link\">\n\t\t\t\t\t\t<h3 class=\"card-heading\"><\/h3>\n\n\t\t\t\t\t\t<div class=\"card-description-link\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"card-description small_body\">The DISRUPT PAD III OS 1,373 represents the largest prospective \u2018real-world\u2019 evidence for the treatment of heavily calcified peripheral artery disease.<\/div>\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/li>\n\t\t\t\t\t\t\t<li class=\"card content-3-or-4-up-card \" role=\"listitem\">\n\t\t\t\t\t\n\t\t\t\t\t<!-- Card Content -->\n\t\t\t\t\t<div class=\"card-heading-description-link\">\n\t\t\t\t\t\t<h3 class=\"card-heading\"><\/h3>\n\n\t\t\t\t\t\t<div class=\"card-description-link\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"card-description small_body\">The data reinforces the predictability of Shockwave IVL and its ability to consistently modify calcium across vessel beds, challenging lesions, and complex patients (CLI, dialysis & female patients).<\/div>\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/li>\n\t\t\t\t\t\t\t<li class=\"card content-3-or-4-up-card \" role=\"listitem\">\n\t\t\t\t\t\n\t\t\t\t\t<!-- Card Content -->\n\t\t\t\t\t<div class=\"card-heading-description-link\">\n\t\t\t\t\t\t<h3 class=\"card-heading\"><\/h3>\n\n\t\t\t\t\t\t<div class=\"card-description-link\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"card-description small_body\">Use of adjunctive technology was at the operator\u2019s discretion \u2013 use of embolic protection was less when Shockwave IVL was used as the only the only calcium modification tool; IVL saw better results with appropriate IVL sizing.<\/div>\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/li>\n\t\t\t\t\t\t\t<li class=\"card content-3-or-4-up-card \" role=\"listitem\">\n\t\t\t\t\t\n\t\t\t\t\t<!-- Card Content -->\n\t\t\t\t\t<div class=\"card-heading-description-link\">\n\t\t\t\t\t\t<h3 class=\"card-heading\"><\/h3>\n\n\t\t\t\t\t\t<div class=\"card-description-link\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"card-description small_body\">Real-world outcomes of DISRUPT PAD III OS are consistent with the previously reported PAD III RCT showing that Shockwave IVL safely and effectively modifies calcium across multiple vessel beds.<\/div>\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/li>\n\t\t\t\t\t<\/ul>\n\t<\/div>\n<\/section>\n\n<section\n\tid=\"block_885ad7cc909aa46f58daf21782aa8077\"\n\tclass=\"block block--spacer-with-optional-divider \"\n\taria-label=\"Spacer section with optional divider\">\n\t<div class=\"spacer-with-optional-divider-container container\">\n\n\t\t<!-- Space Above -->\n\t\t<div\n\t\t\tclass=\"space-above\"\n\t\t\tstyle=\"--aboveDesktop: 60px; --aboveMobile: 30px;\"\n\t\t\taria-hidden=\"true\"\n\t\t\trole=\"presentation\">\n\t\t<\/div>\n\n\t\t<!-- Optional Divider -->\n\t\t\n\t\t<!-- Space Below -->\n\t\t<div\n\t\t\tclass=\"space-below\"\n\t\t\tstyle=\"--belowDesktop: 0px; --belowMobile: 0px;\"\n\t\t\taria-hidden=\"true\"\n\t\t\trole=\"presentation\">\n\t\t<\/div>\n\n\t<\/div>\n<\/section>\n\n\n<section id=\"block_10216b79977bc89ecf5980df260365d9\" class=\"block block--attribution \" role=\"region\" aria-labelledby=\"block_10216b79977bc89ecf5980df260365d9-heading\" aria-describedby=\"block_10216b79977bc89ecf5980df260365d9-desc\">\n\t<div class=\"container\">\n\t\t<div class=\"container-inner\">\n\t\t\t\t\t\t\t<h3 id=\"block_10216b79977bc89ecf5980df260365d9-heading\" class=\"heading\">\n\t\t\t\t\tStudy Leadership\t\t\t\t<\/h3>\n\t\t\t\t\t\t<p id=\"block_10216b79977bc89ecf5980df260365d9-desc\" class=\"sr-only\">This section contains attributions including profile pictures, titles, descriptions, and Twitter handles.<\/p>\n\n\t\t\t\t\t\t\t<ul class=\"attributions-container\" role=\"list\">\n\t\t\t\t\t\t\t\t\t\t\t<li class=\"attribution\" role=\"listitem\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"details\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"title\">Ehrin J. Armstrong, MD<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"description\">Interventional Cardiologist, Advanced Heart & Vein Center, Thornton, CO<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"twitter-handle\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/twitter.com\/ehrin_armstrong\" target=\"_blank\" rel=\"noopener noreferrer\">@ehrin_armstrong<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t\t\t\t<li class=\"attribution\" role=\"listitem\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"details\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"title\">George Adams, MD<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"description\">Director of Clinical Cardioascular & Peripheral Vascular Research, UNC REX, Garner, NC<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t\t\t\t<li class=\"attribution\" role=\"listitem\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"details\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"title\">Peter A. Soukas, MD<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"description\">Director of Vascular Medicine, Brown University, Providence, RI<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"twitter-handle\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/twitter.com\/petersoukas\" target=\"_blank\" rel=\"noopener noreferrer\">@petersoukas<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t\t\t\t<li class=\"attribution\" role=\"listitem\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"details\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"title\">Sarang S. Mangalmurti, MD<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"description\">Interventional Cardiologist, Main Line Health, Bryn Mawr, PA<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"twitter-handle\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/twitter.com\/sarangmangalmu1\" target=\"_blank\" rel=\"noopener noreferrer\">@sarangmangalmu1<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t\t\t\t<li class=\"attribution\" role=\"listitem\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"details\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"title\">Nicolas W. Shammas, MD<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"description\">Medical Director of Cardiology Services, Trinity Bettendorf Hospital, Bettendorf, IA<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"twitter-handle\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/twitter.com\/nicolas_shammas\" target=\"_blank\" rel=\"noopener noreferrer\">@nicolas_shammas<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t\t\t\t<li class=\"attribution\" role=\"listitem\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"details\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"title\">Anderson Mehrle, MD<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"description\">Interventional Cardiologist, BlueStem Cardiology, Bartlesville, OK<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"twitter-handle\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/twitter.com\/mehrleal\" target=\"_blank\" rel=\"noopener noreferrer\">@mehrleal<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t\t\t\t<li class=\"attribution\" role=\"listitem\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"details\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"title\">Barry Bertolet, MD<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"description\">Director of Cardiac Catheterization Laboratory NMMC, Cardiology Associates of North Mississippi, Tupelo, MS<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t\t\t\t<li class=\"attribution\" role=\"listitem\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"details\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"title\">William A. Gray, MD<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"description\">Professor of Medicine, Main Line Health, Wynnewood, PA<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t\t\t\t<li class=\"attribution\" role=\"listitem\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"details\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"title\">Gunnar Tepe, MD<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"description\">Professor of Radiology, Head of Diagnostic & Interventional Radiology, RoMed Clinic, Rosenheim, Germany<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t\t\t\t<li class=\"attribution\" role=\"listitem\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"details\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"title\">Edward Y. Woo, MD<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"description\">Director of Vascular Program, Chief of Vascular Surgery, MedStar Regional, Washington D.C.<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t\t\t\t<li class=\"attribution\" role=\"listitem\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"details\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"title\">James F. McKinsey, MD<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"description\">Professor of Vascular Surgery & Interventional Radiology, Mount Sinai Health System, New York, NY  <\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"twitter-handle\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/twitter.com\/jfmvasc\" target=\"_blank\" rel=\"noopener noreferrer\">@jfmvasc<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t\t\t\t<li class=\"attribution\" role=\"listitem\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"details\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"title\">Andrew Holden, MD<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"description\">Professor, Director of Interventional Radiology, Auckland Hospital, Grafton, Auckland, New Zealand<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t\t\t\t<li class=\"attribution\" role=\"listitem\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"details\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"title\">Sahil A. Parikh, MD<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"description\">Associate Professor of Medicine, Columbia University, New York, NY<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"twitter-handle\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/twitter.com\/sahilparikhmd\" target=\"_blank\" rel=\"noopener noreferrer\">@sahilparikhmd<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t\t\t\t<li class=\"attribution\" role=\"listitem\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"details\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"title\">William Bachinsky, MD<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"description\">Cardiologist, Penn State Health Holy Spirit Medical Center, Mechanicsburg, PA<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t\t<\/ul>\n\t\t\t\t\t<\/div>\n\t<\/div>\n<\/section>\n\n<section id=\"block_127b051fa91027256fad9883c3bcb28e\" class=\"block block--featured-clinical-evidence \" aria-labelledby=\"featured-clinical-evidence-title\">\n\t\t\t<div class=\"featured-clinical-evidence--top text_colors \">\n\t\t\t<div class=\"featured-clinical-evidence--title\">\n\t\t\t\t\t\t\t\t\t<h2 id=\"featured-clinical-evidence-title\" class=\"heading\">More Clinical Evidence<\/h2>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"featured-clinical-evidence__btn-wrap featured-clinical-evidence__btn-wrap-top u--hidden u-md-block\">\n\t\t\t\t\t\t\n<a data-atom=\"button\" class=\" btn--secondary\" href=\"https:\/\/shockwavemedical.com\/en-eu\/clinical-evidence\/?disease-state_terms%5B%5D=peripheral-artery-disease-en-uk&amp;sort_order=date_desc&amp;pageNumber=1\" target=\"_self\" aria-label=\"Explore peripheral studies - link to page\">Explore peripheral studies<i aria-hidden=\"true\" class=\"fa-sharp fa-arrow-right fa-light\"><\/i><\/a>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\n\t\t\t\t\t\t\t<div class=\"featured-clinical-evidence__btn-wrap featured-clinical-evidence__btn-wrap-bottom u--block u-md-hidden\">\n\t\t\t\t\t\n<a data-atom=\"button\" class=\" btn--secondary\" href=\"https:\/\/shockwavemedical.com\/en-eu\/clinical-evidence\/?disease-state_terms%5B%5D=peripheral-artery-disease-en-uk&amp;sort_order=date_desc&amp;pageNumber=1\" target=\"_self\" aria-label=\"Explore peripheral studies - link to page\">Explore peripheral studies<i aria-hidden=\"true\" class=\"fa-sharp fa-arrow-right fa-light\"><\/i><\/a>\t\t\t\t<\/div>\n\t\t\t\n\t\t\t\t\t<\/div>\n\t\t<ul class=\"featured-clinical-evidence-list text_colors\" role=\"list\">\n\t\t\t\t\t\t<li class=\"featured-clinical-evidence-item\" role=\"listitem\" aria-labelledby=\"post-title-6686\" aria-describedby=\"post-category-6686 post-excerpt-6686\">\n\t\t\t\t\t<div class=\"featured-clinical-evidence-item--text-container\" id=\"post-title-6686\">\n\t\t\t\t\t\t<a href=\"https:\/\/shockwavemedical.com\/en-eu\/clinical-evidence\/btk-ii\/\" class=\"featured-clinical-evidence-item--title\">\n\t\t\t\t\t\t\tDISRUPT BTK II\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"featured-clinical-evidence-item--arrow\" aria-hidden=\"true\"><svg width=\"25\" height=\"27\" viewBox=\"0 0 25 27\" fill=\"none\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M3.5 26H21a2.5 2.5 0 002.5-2.5V7.875L16.625 1H6a2.5 2.5 0 00-2.5 2.5v3.75\" stroke=\"#5B6770\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\"\/><path d=\"M16 1v7.5h7.5M4.75 19.75a3.75 3.75 0 100-7.498 3.75 3.75 0 000 7.498v0zm5 1.25l-1.875-1.875\" stroke=\"#5B6770\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\"\/><\/svg><\/div>\n\t\t\t\t\t\t<div class=\"featured-clinical-evidence-item--arrow-hover\" aria-hidden=\"true\"><svg width=\"25\" height=\"27\" viewBox=\"0 0 25 27\" fill=\"none\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M3.5 26H21a2.5 2.5 0 002.5-2.5V7.875L16.625 1H6a2.5 2.5 0 00-2.5 2.5v3.75\" stroke=\"#00D2FF\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\"\/><path d=\"M16 1v7.5h7.5M4.75 19.75a3.75 3.75 0 100-7.498 3.75 3.75 0 000 7.498v0zm5 1.25l-1.875-1.875\" stroke=\"#00D2FF\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\"\/><\/svg><\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t<div class=\"featured-clinical-evidence-item--excerpt\" id=\"post-excerpt-6686\">\n\t\t\t\t\t\tGlobal prospective, multi-center, single-arm  study assessing the safety and effectiveness of Shockwave peripheral IVL in treating long, calcified BTK lesions. \t\t\t\t\t<\/div>\n\t\t\t\t\t<div class=\"featured-clinical-evidence-item--category\" id=\"post-category-6686\">\n\t\t\t\t\t\tPeripheral IVL\t\t\t\t\t<\/div>\n\t\t\t\t<\/li>\n\t\t\t\t\t\t<li class=\"featured-clinical-evidence-item\" role=\"listitem\" aria-labelledby=\"post-title-6554\" aria-describedby=\"post-category-6554 post-excerpt-6554\">\n\t\t\t\t\t<div class=\"featured-clinical-evidence-item--text-container\" id=\"post-title-6554\">\n\t\t\t\t\t\t<a href=\"https:\/\/shockwavemedical.com\/en-eu\/clinical-evidence\/pad-iii-rct\/\" class=\"featured-clinical-evidence-item--title\">\n\t\t\t\t\t\t\tDISRUPT PAD III Randomized Clinical Trial\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"featured-clinical-evidence-item--arrow\" aria-hidden=\"true\"><svg width=\"25\" height=\"27\" viewBox=\"0 0 25 27\" fill=\"none\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M3.5 26H21a2.5 2.5 0 002.5-2.5V7.875L16.625 1H6a2.5 2.5 0 00-2.5 2.5v3.75\" stroke=\"#5B6770\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\"\/><path d=\"M16 1v7.5h7.5M4.75 19.75a3.75 3.75 0 100-7.498 3.75 3.75 0 000 7.498v0zm5 1.25l-1.875-1.875\" stroke=\"#5B6770\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\"\/><\/svg><\/div>\n\t\t\t\t\t\t<div class=\"featured-clinical-evidence-item--arrow-hover\" aria-hidden=\"true\"><svg width=\"25\" height=\"27\" viewBox=\"0 0 25 27\" fill=\"none\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M3.5 26H21a2.5 2.5 0 002.5-2.5V7.875L16.625 1H6a2.5 2.5 0 00-2.5 2.5v3.75\" stroke=\"#00D2FF\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\"\/><path d=\"M16 1v7.5h7.5M4.75 19.75a3.75 3.75 0 100-7.498 3.75 3.75 0 000 7.498v0zm5 1.25l-1.875-1.875\" stroke=\"#00D2FF\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\"\/><\/svg><\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t<div class=\"featured-clinical-evidence-item--excerpt\" id=\"post-excerpt-6554\">\n\t\t\t\t\t\tThe largest-ever randomized clinical study of Shockwave peripheral IVL treatment in severely calcified peripheral lesions, out to 24 months.\t\t\t\t\t<\/div>\n\t\t\t\t\t<div class=\"featured-clinical-evidence-item--category\" id=\"post-category-6554\">\n\t\t\t\t\t\tPeripheral IVL\t\t\t\t\t<\/div>\n\t\t\t\t<\/li>\n\t\t\t\t\t\t<li class=\"featured-clinical-evidence-item\" role=\"listitem\" aria-labelledby=\"post-title-6593\" aria-describedby=\"post-category-6593 post-excerpt-6593\">\n\t\t\t\t\t<div class=\"featured-clinical-evidence-item--text-container\" id=\"post-title-6593\">\n\t\t\t\t\t\t<a href=\"https:\/\/shockwavemedical.com\/en-eu\/clinical-evidence\/pad-ii\/\" class=\"featured-clinical-evidence-item--title\">\n\t\t\t\t\t\t\tDISRUPT PAD II\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"featured-clinical-evidence-item--arrow\" aria-hidden=\"true\"><svg width=\"25\" height=\"27\" viewBox=\"0 0 25 27\" fill=\"none\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M3.5 26H21a2.5 2.5 0 002.5-2.5V7.875L16.625 1H6a2.5 2.5 0 00-2.5 2.5v3.75\" stroke=\"#5B6770\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\"\/><path d=\"M16 1v7.5h7.5M4.75 19.75a3.75 3.75 0 100-7.498 3.75 3.75 0 000 7.498v0zm5 1.25l-1.875-1.875\" stroke=\"#5B6770\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\"\/><\/svg><\/div>\n\t\t\t\t\t\t<div class=\"featured-clinical-evidence-item--arrow-hover\" aria-hidden=\"true\"><svg width=\"25\" height=\"27\" viewBox=\"0 0 25 27\" fill=\"none\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M3.5 26H21a2.5 2.5 0 002.5-2.5V7.875L16.625 1H6a2.5 2.5 0 00-2.5 2.5v3.75\" stroke=\"#00D2FF\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\"\/><path d=\"M16 1v7.5h7.5M4.75 19.75a3.75 3.75 0 100-7.498 3.75 3.75 0 000 7.498v0zm5 1.25l-1.875-1.875\" stroke=\"#00D2FF\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\"\/><\/svg><\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t<div class=\"featured-clinical-evidence-item--excerpt\" id=\"post-excerpt-6593\">\n\t\t\t\t\t\tCore lab adjudicated, long-term, multi-center study exclusively enrolling heavily calcified lesions building upon DISRUPT PAD I.\t\t\t\t\t<\/div>\n\t\t\t\t\t<div class=\"featured-clinical-evidence-item--category\" id=\"post-category-6593\">\n\t\t\t\t\t\tPeripheral IVL\t\t\t\t\t<\/div>\n\t\t\t\t<\/li>\n\t\t\t<\/ul>\n<\/section>\n\n\n<section id=\"block_173cbe6dc273f30ce8d550231ce88699\" class=\"block block--related-posts \" aria-labelledby=\"related-posts-title\">\n\t<div class=\"related-posts--title container\">\n\t\t<h2 id=\"related-posts-title\" class=\"text_colors\">From Our Education Library<\/h2>\n\t\t<div class=\"related-posts__btn-dots-wrap\">\n\t\t\t\n<a data-atom=\"button\" class=\"btn--secondary\" href=\"https:\/\/shockwavemedical.com\/en-eu\/education\/?technology_terms%5B%5D=peripheral-ivl-en-uk&amp;sort_order=date_desc&amp;pageNumber=1\" target=\"_self\" aria-label=\"Explore more - link to page\">Explore more<i aria-hidden=\"true\" class=\"fa-sharp fa-arrow-right fa-light\"><\/i><\/a>\t\t\t<div class=\"related-posts--dots cards_slider_dots\" aria-hidden=\"true\"><\/div>\n\t\t<\/div>\n\t<\/div>\n\n\t<ul class=\"related-posts-list cards_slider\" role=\"list\">\n\t\t\t\t\t\t<li class=\"related-posts-item card_slide\" role=\"listitem\">\n\t\t\t\t\t<figure class=\"related-posts-item--image\">\n\t\t\t\t\t\t<img decoding=\"async\" width=\"386\" height=\"540\" data-src=\"https:\/\/shockwavemedical.com\/wp-content\/uploads\/2026\/02\/Dr-Saratzis-index-image.png\" class=\"attachment-full size-full wp-post-image lazyload\" alt=\"Shockwave IVL as First-line: The Real World Impact of the V-PAD Consensus\" data-srcset=\"https:\/\/shockwavemedical.com\/wp-content\/uploads\/2026\/02\/Dr-Saratzis-index-image.png 386w, https:\/\/shockwavemedical.com\/wp-content\/uploads\/2026\/02\/Dr-Saratzis-index-image-214x300.png 214w\" data-sizes=\"(max-width: 386px) 100vw, 386px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 386px; --smush-placeholder-aspect-ratio: 386\/540;\" \/>\t\t\t\t\t\t<div class=\"thumbnail-arrow\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t<i class=\"fa-regular fa-arrow-right\"><\/i>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/figure>\n\n\t\t\t\t\t<div class=\"related-posts-item--text-container\" id=\"post-title-13416\">\n\t\t\t\t\t\t<a href=\"https:\/\/shockwavemedical.com\/en-eu\/education\/real-world-impact-of-vpad-consensus-with-prof-thanos-saratzis\/\" class=\"related-posts-item--title\" aria-labelledby=\"post-title-13416\" aria-describedby=\"post-category-13416\">\n\t\t\t\t\t\t\tShockwave IVL as First-line: The Real World Impact of the V-PAD Consensus\t\t\t\t\t\t<\/a>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t<div class=\"related-posts-item--category\" id=\"post-category-13416\">\n\t\t\t\t\t\t<div class=\"tags\"><strong>Clinical Evidence<\/strong> <\/div>\t\t\t\t\t<\/div>\n\t\t\t\t<\/li>\n\t\t\t\t\t\t<li class=\"related-posts-item card_slide\" role=\"listitem\">\n\t\t\t\t\t<figure class=\"related-posts-item--image\">\n\t\t\t\t\t\t<img decoding=\"async\" width=\"440\" height=\"570\" data-src=\"https:\/\/shockwavemedical.com\/wp-content\/uploads\/2025\/09\/Javelin-Case-2-Images-01.png\" class=\"attachment-full size-full wp-post-image lazyload\" alt=\"Shockwave Javelin for Below the Ankle Revascularization in a Patient with CLTI\" data-srcset=\"https:\/\/shockwavemedical.com\/wp-content\/uploads\/2025\/09\/Javelin-Case-2-Images-01.png 440w, https:\/\/shockwavemedical.com\/wp-content\/uploads\/2025\/09\/Javelin-Case-2-Images-01-232x300.png 232w\" data-sizes=\"(max-width: 440px) 100vw, 440px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 440px; --smush-placeholder-aspect-ratio: 440\/570;\" \/>\t\t\t\t\t\t<div class=\"thumbnail-arrow\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t<i class=\"fa-regular fa-arrow-right\"><\/i>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/figure>\n\n\t\t\t\t\t<div class=\"related-posts-item--text-container\" id=\"post-title-12658\">\n\t\t\t\t\t\t<a href=\"https:\/\/shockwavemedical.com\/en-eu\/education\/shockwave-javelin-for-below-the-ankle-revascularization-in-a-patient-with-clti\/\" class=\"related-posts-item--title\" aria-labelledby=\"post-title-12658\" aria-describedby=\"post-category-12658\">\n\t\t\t\t\t\t\tShockwave Javelin for Below the Ankle Revascularization in a Patient with CLTI\t\t\t\t\t\t<\/a>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t<div class=\"related-posts-item--category\" id=\"post-category-12658\">\n\t\t\t\t\t\t<div class=\"tags\"><strong>Case Reviews<\/strong> <\/div>\t\t\t\t\t<\/div>\n\t\t\t\t<\/li>\n\t\t\t\t\t\t<li class=\"related-posts-item card_slide\" role=\"listitem\">\n\t\t\t\t\t<figure class=\"related-posts-item--image\">\n\t\t\t\t\t\t<img decoding=\"async\" width=\"386\" height=\"540\" data-src=\"https:\/\/shockwavemedical.com\/wp-content\/uploads\/2025\/03\/BTK-II-Acute-30-Day-Outcomes-Index-Image.png\" class=\"attachment-full size-full wp-post-image lazyload\" alt=\"DISRUPT BTK II Acute & 30-Day Outcomes with Dr. Venita Chandra and Dr. Ehrin Armstrong\" data-srcset=\"https:\/\/shockwavemedical.com\/wp-content\/uploads\/2025\/03\/BTK-II-Acute-30-Day-Outcomes-Index-Image.png 386w, https:\/\/shockwavemedical.com\/wp-content\/uploads\/2025\/03\/BTK-II-Acute-30-Day-Outcomes-Index-Image-214x300.png 214w\" data-sizes=\"(max-width: 386px) 100vw, 386px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 386px; --smush-placeholder-aspect-ratio: 386\/540;\" \/>\t\t\t\t\t\t<div class=\"thumbnail-arrow\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t<i class=\"fa-regular fa-arrow-right\"><\/i>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/figure>\n\n\t\t\t\t\t<div class=\"related-posts-item--text-container\" id=\"post-title-11943\">\n\t\t\t\t\t\t<a href=\"https:\/\/shockwavemedical.com\/en-eu\/education\/disrupt-btk-ii-acute-30-day-outcomes-with-dr-venita-chandra-and-dr-ehrin-armstrong\/\" class=\"related-posts-item--title\" aria-labelledby=\"post-title-11943\" aria-describedby=\"post-category-11943\">\n\t\t\t\t\t\t\tDISRUPT BTK II Acute & 30-Day Outcomes with Dr. Venita Chandra and Dr. Ehrin Armstrong\t\t\t\t\t\t<\/a>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t<div class=\"related-posts-item--category\" id=\"post-category-11943\">\n\t\t\t\t\t\t<div class=\"tags\"><strong>Clinical Evidence<\/strong> <\/div>\t\t\t\t\t<\/div>\n\t\t\t\t<\/li>\n\t\t\t\t\t\t<li class=\"related-posts-item card_slide\" role=\"listitem\">\n\t\t\t\t\t<figure class=\"related-posts-item--image\">\n\t\t\t\t\t\t<img decoding=\"async\" width=\"386\" height=\"540\" data-src=\"https:\/\/shockwavemedical.com\/wp-content\/uploads\/2025\/03\/BTK-II-Acute-Outcomes-Index-Image.png\" class=\"attachment-full size-full wp-post-image lazyload\" alt=\"DISRUPT BTK II Acute Outcomes: Physician Perspectives with Prof. Holden & Dr. Lakshminarayan\" data-srcset=\"https:\/\/shockwavemedical.com\/wp-content\/uploads\/2025\/03\/BTK-II-Acute-Outcomes-Index-Image.png 386w, https:\/\/shockwavemedical.com\/wp-content\/uploads\/2025\/03\/BTK-II-Acute-Outcomes-Index-Image-214x300.png 214w\" data-sizes=\"(max-width: 386px) 100vw, 386px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 386px; --smush-placeholder-aspect-ratio: 386\/540;\" \/>\t\t\t\t\t\t<div class=\"thumbnail-arrow\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t<i class=\"fa-regular fa-arrow-right\"><\/i>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/figure>\n\n\t\t\t\t\t<div class=\"related-posts-item--text-container\" id=\"post-title-11935\">\n\t\t\t\t\t\t<a href=\"https:\/\/shockwavemedical.com\/en-eu\/education\/disrupt-btk-ii-acute-outcomes-physician-perspectives-with-prof-holden-dr-lakshminarayan\/\" class=\"related-posts-item--title\" aria-labelledby=\"post-title-11935\" aria-describedby=\"post-category-11935\">\n\t\t\t\t\t\t\tDISRUPT BTK II Acute Outcomes: Physician Perspectives with Prof. Holden & Dr. Lakshminarayan\t\t\t\t\t\t<\/a>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t<div class=\"related-posts-item--category\" id=\"post-category-11935\">\n\t\t\t\t\t\t<div class=\"tags\"><strong>Clinical Evidence<\/strong> <\/div>\t\t\t\t\t<\/div>\n\t\t\t\t<\/li>\n\t\t\t<\/ul>\n<\/section>\n\n\n<section id=\"block_7aeefb9b6967797b911335dcde70e615\" class=\"block block--wysiwyg wysiwyg_styles u-bgColorNone shockwave container\">\n\t<div class=\"u-wysiwyg u-animation\">\n\t\t<hr \/>\n<p><span class=\"legal_copy\">*Presence of fluoroscopic evidence of calcification by PARC definition: 1) on parallel sides of the vessel and 2) extending > 50% the length of the lesion if lesion is \u226550 mm in length; or extending for minimum of 20 mm if lesion is <50 mm in length.<br \/>\n**PARC definition.<br \/>\n<sup>\u2020<\/sup>Ca modifying therapy: atherectomy and\/or scoring\/cutting balloon.<br \/>\n<sup>\u2021<\/sup>PAD OS data analysis is consistent with prior PAD II data analysis and continues to support 1.1:1 sizing in the product instructions for use (IFU).<\/span><\/p>\n<p><span class=\"legal_copy\">1: Tepe et al, J Am Coll Cardiol Intv 2021.<br \/>\n2: Armstrong EJ, Adams G, Soukas PA, Mangalmurti SS, Shammas NW, Mehrle A, Bertolet B, Gray WA, Tepe G, Woo EY, McKinsey JF, Holden A, Parikh SA. Intravascular Lithotripsy for Peripheral Artery Calcification: 30-Day Outcomes From the Disrupt PAD III Observational Study. J Endovasc Ther. 2024 Oct 18:15266028241283716. doi: 10.1177\/15266028241283716. Epub ahead of print. PMID: 39422234.<\/span><\/p>\n<p>\u00a0<\/p>\n\t<\/div>\n\t<\/section>","protected":false},"excerpt":{"rendered":"<p>The largest prospective real-world evidence for the treatment of complex, heavily calcified peripheral arterial disease (PAD).<\/p>\n","protected":false},"featured_media":3969,"template":"","format":[],"meta":{"_acf_changed":true,"content-type":""},"disease-state":[151,167],"product-tag":[283,291],"specialty":[295,328,332,336,344],"technology":[324],"class_list":["post-6527","clinical-evidence","type-clinical-evidence","status-publish","has-post-thumbnail","hentry","disease-state-below-the-knee-btk","disease-state-peripheral-artery-disease-en-uk","product-tag-shockwave-m5","product-tag-shockwave-s4-en-uk","specialty-fellows-residents-en-uk","specialty-interventional-cardiologists-en-uk","specialty-interventional-radiologists-en-uk","specialty-nurses-technologists-en-uk","specialty-vascular-surgeons-en-uk","technology-peripheral-ivl-en-uk"],"acf":[],"_links":{"self":[{"href":"https:\/\/shockwavemedical.com\/en-eu\/wp-json\/wp\/v2\/clinical-evidence\/6527","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/shockwavemedical.com\/en-eu\/wp-json\/wp\/v2\/clinical-evidence"}],"about":[{"href":"https:\/\/shockwavemedical.com\/en-eu\/wp-json\/wp\/v2\/types\/clinical-evidence"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/shockwavemedical.com\/en-eu\/wp-json\/wp\/v2\/media\/3969"}],"wp:attachment":[{"href":"https:\/\/shockwavemedical.com\/en-eu\/wp-json\/wp\/v2\/media?parent=6527"}],"wp:term":[{"taxonomy":"disease-state","embeddable":true,"href":"https:\/\/shockwavemedical.com\/en-eu\/wp-json\/wp\/v2\/disease-state?post=6527"},{"taxonomy":"format","embeddable":true,"href":"https:\/\/shockwavemedical.com\/en-eu\/wp-json\/wp\/v2\/format?post=6527"},{"taxonomy":"product-tag","embeddable":true,"href":"https:\/\/shockwavemedical.com\/en-eu\/wp-json\/wp\/v2\/product-tag?post=6527"},{"taxonomy":"specialty","embeddable":true,"href":"https:\/\/shockwavemedical.com\/en-eu\/wp-json\/wp\/v2\/specialty?post=6527"},{"taxonomy":"technology","embeddable":true,"href":"https:\/\/shockwavemedical.com\/en-eu\/wp-json\/wp\/v2\/technology?post=6527"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}