{"id":7995,"date":"2019-02-05T15:45:00","date_gmt":"2019-02-05T21:45:00","guid":{"rendered":"https:\/\/shockwavemedical.com\/clinical-evidence\/disrupt-cad-i\/"},"modified":"2025-01-23T09:43:30","modified_gmt":"2025-01-23T15:43:30","slug":"cad-i","status":"publish","type":"clinical-evidence","link":"https:\/\/shockwavemedical.com\/en-eu\/clinical-evidence\/cad-i\/","title":{"rendered":"DISRUPT CAD I"},"content":{"rendered":"\n<section id=\"block_dc0ec411a039428f7cf847f5ba403eaf\" class=\"block block--primary-header u-darkMode u-bgColor_primary\"\n\tstyle=\"--desktop-bg-image: url('https:\/\/shockwavemedical.com\/wp-content\/uploads\/2024\/11\/Background-Pulses.png');\n\t\t\t\t --mobile-bg-image: url('');\">\n\n\t<div class=\"primary-header-container text_colors\">\n\n\t\t<!-- Heading -->\n\t\t<div class=\"heading\">\n\t\t\t<h1 class=\"main-heading\">DISRUPT CAD I CE Mark Study <\/h1>\n\t\t\t<h3 class=\"sub-heading\">A single-arm, pre-market study demonstrating the safety and performance of Shockwave Intravascular Lithotripsy (IVL) in heavily calcified, coronary lesions prior to stenting and followed to 6 months; also included an OCT sub-study demonstrating Shockwave IVL\u2019s mechanism of action. <\/h3>\n\t\t<\/div>\n\n\t\t<!-- Optional links -->\n\t\t\t\t\t<div class=\"links\">\n\t\t\t\t\n<a data-atom=\"button\" class=\"btn--line optional-button on-dark\" href=\"https:\/\/www.ahajournals.org\/doi\/pdf\/10.1161\/CIRCULATIONAHA.118.036531\" target=\"_blank\" aria-label=\"Download full results - opens in a new tab\" rel=\"noopener\">Download full results<i aria-hidden=\"true\" class=\"fa-sharp fa-arrow-right fa-solid\"><\/i><\/a>\n<a data-atom=\"button\" class=\"btn--line optional-button on-dark\" href=\"https:\/\/www.jacc.org\/doi\/10.1016\/j.jcmg.2017.05.012\" target=\"_blank\" aria-label=\"DISRUPT CAD I OCT Sub-study Results - opens in a new tab\" rel=\"noopener\">DISRUPT CAD I OCT Sub-study Results<i aria-hidden=\"true\" class=\"fa-sharp fa-arrow-right fa-solid\"><\/i><\/a>\t\t\t<\/div>\n\t\t\n\t\t<!-- links - J&J -->\n\t\t\n\t\t<!-- Social share -->\n\t\t\t\t<!-- Foreground for Desktop -->\n\t\t\t\t\t<div class=\"desktop-foreground-file\">\n\t\t\t\t\t\t\t\t\t<img decoding=\"async\" data-src=\"https:\/\/shockwavemedical.com\/wp-content\/uploads\/2024\/11\/DISRUPT-CAD-I-Clinical-Hero-Images.png\" alt=\"DISRUPT CAD I logo\" role=\"img\" aria-label=\"Foreground image for desktop\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" class=\"lazyload\" style=\"--smush-placeholder-width: 955px; --smush-placeholder-aspect-ratio: 955\/970;\">\n\t\t\t\t\t\t\t<\/div>\n\t\t\n\t\t<!-- Foreground for Mobile -->\n\t\t\t\t\t<div class=\"mobile-foreground-file\">\n\t\t\t\t\t\t\t\t\t<img decoding=\"async\" data-src=\"https:\/\/shockwavemedical.com\/wp-content\/uploads\/2024\/11\/Clinical-Hero-Images-mobile-14.png\" alt=\"DISRUPT CAD I logo\" role=\"img\" aria-label=\"Foreground image for mobile\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" class=\"lazyload\" style=\"--smush-placeholder-width: 814px; --smush-placeholder-aspect-ratio: 814\/400;\">\n\t\t\t\t\t\t\t<\/div>\n\t\t\t<\/div>\n<\/section>\n\n\n<section id=\"block_4d74f1433af3246047b1d208d00481c9\" class=\"block block--attribution \" role=\"region\" aria-labelledby=\"block_4d74f1433af3246047b1d208d00481c9-heading\" aria-describedby=\"block_4d74f1433af3246047b1d208d00481c9-desc\">\n\t<div class=\"container\">\n\t\t<div class=\"container-inner\">\n\t\t\t\t\t\t\t<h3 id=\"block_4d74f1433af3246047b1d208d00481c9-heading\" class=\"heading\">\n\t\t\t\t\tStudy Leadership\t\t\t\t<\/h3>\n\t\t\t\t\t\t<p id=\"block_4d74f1433af3246047b1d208d00481c9-desc\" class=\"sr-only\">This section contains attributions including profile pictures, titles, descriptions, and Twitter handles.<\/p>\n\n\t\t\t\t\t\t\t<ul class=\"attributions-container\" role=\"list\">\n\t\t\t\t\t\t\t\t\t\t\t<li class=\"attribution\" role=\"listitem\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"details\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"title\">Jean Fajadet, MD <\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"description\">Clinical Pasteur, Toulouse, France<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t\t\t\t<li class=\"attribution\" role=\"listitem\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"details\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"title\">Prof. Carlo Di Mario<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"description\">AOU Careggi SOD Interventistica, Firenze, Italy <\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t\t<\/ul>\n\t\t\t\t\t<\/div>\n\t<\/div>\n<\/section>\n\n\n<section id=\"block_b08721f73bb1777d33657187cc78ca77\" class=\"block block--stat-callout \" role=\"region\" aria-labelledby=\"statCalloutTitle\" aria-describedby=\"statCalloutDesc\">\n\t<h2 id=\"statCalloutTitle\" class=\"sr-only\">Statistics Callout<\/h2> <!-- Add a hidden heading for accessibility -->\n\t<p id=\"statCalloutDesc\" class=\"sr-only\">This section presents key statistical information with numbers and descriptions.<\/p> <!-- Hidden description -->\n\n\t<!-- Changing container to ul for better semantics -->\n\t<ul class=\"container\" role=\"list\">\n\t\t\t\t\t\t<!-- Each card is now an li element for semantic correctness -->\n\t\t\t<li class=\"card\" id=\"block_b08721f73bb1777d33657187cc78ca77-card-0\" role=\"listitem\" aria-labelledby=\"block_b08721f73bb1777d33657187cc78ca77-card-0-number\" aria-describedby=\"block_b08721f73bb1777d33657187cc78ca77-card-0-description\">\n\t\t\t\t<div class=\"card-top\">\n\t\t\t\t\t\t\t\t\t\t\t<div class=\"card-number\" id=\"block_b08721f73bb1777d33657187cc78ca77-card-0-number\">60<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"card-symbol\">\n\t\t\t\t\t\t\t<span><\/span>\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t\t\t<div class=\"card-description font--p\" id=\"block_b08721f73bb1777d33657187cc78ca77-card-0-description\">\n\t\t\t\t\t\tPatients\t\t\t\t\t<\/div>\n\t\t\t\t\n\t\t\t<\/li>\n\t\t\t\t\t<!-- Each card is now an li element for semantic correctness -->\n\t\t\t<li class=\"card\" id=\"block_b08721f73bb1777d33657187cc78ca77-card-1\" role=\"listitem\" aria-labelledby=\"block_b08721f73bb1777d33657187cc78ca77-card-1-number\" aria-describedby=\"block_b08721f73bb1777d33657187cc78ca77-card-1-description\">\n\t\t\t\t<div class=\"card-top\">\n\t\t\t\t\t\t\t\t\t\t\t<div class=\"card-number\" id=\"block_b08721f73bb1777d33657187cc78ca77-card-1-number\">7<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"card-symbol\">\n\t\t\t\t\t\t\t<span><\/span>\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t\t\t<div class=\"card-description font--p\" id=\"block_b08721f73bb1777d33657187cc78ca77-card-1-description\">\n\t\t\t\t\t\tEuropean sites\t\t\t\t\t<\/div>\n\t\t\t\t\n\t\t\t<\/li>\n\t\t\t\t\t<!-- Each card is now an li element for semantic correctness -->\n\t\t\t<li class=\"card\" id=\"block_b08721f73bb1777d33657187cc78ca77-card-2\" role=\"listitem\" aria-labelledby=\"block_b08721f73bb1777d33657187cc78ca77-card-2-number\" aria-describedby=\"block_b08721f73bb1777d33657187cc78ca77-card-2-description\">\n\t\t\t\t<div class=\"card-top\">\n\t\t\t\t\t\t\t\t\t\t\t<div class=\"card-number\" id=\"block_b08721f73bb1777d33657187cc78ca77-card-2-number\">100<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"card-symbol\">\n\t\t\t\t\t\t\t<span>%<\/span>\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t\t\t<div class=\"card-description font--p\" id=\"block_b08721f73bb1777d33657187cc78ca77-card-2-description\">\n\t\t\t\t\t\tSevere calcified lesions\t\t\t\t\t<\/div>\n\t\t\t\t\n\t\t\t<\/li>\n\t\t\t\t\t<!-- Each card is now an li element for semantic correctness -->\n\t\t\t<li class=\"card\" id=\"block_b08721f73bb1777d33657187cc78ca77-card-3\" role=\"listitem\" aria-labelledby=\"block_b08721f73bb1777d33657187cc78ca77-card-3-number\" aria-describedby=\"block_b08721f73bb1777d33657187cc78ca77-card-3-description\">\n\t\t\t\t<div class=\"card-top\">\n\t\t\t\t\t\t\t\t\t\t\t<div class=\"card-number\" id=\"block_b08721f73bb1777d33657187cc78ca77-card-3-number\">6<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"card-symbol\">\n\t\t\t\t\t\t\t<span><\/span>\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t\t\t<div class=\"card-description font--p\" id=\"block_b08721f73bb1777d33657187cc78ca77-card-3-description\">\n\t\t\t\t\t\tMonth follow-up\t\t\t\t\t<\/div>\n\t\t\t\t\n\t\t\t<\/li>\n\t\t\t\t<\/ul>\n<\/section>\n\n\n<section id=\"block_a29c5943c5f11579a592db1563a1fa92\" class=\"block block--study-design-patient-chars \" role=\"region\" aria-labelledby=\"block_a29c5943c5f11579a592db1563a1fa92-heading\">\n\t<div class=\"container\">\n\t\t\t\t\t<div class=\"heading-row wysiwyg_styles\">\n\t\t\t\t\t\t\t\t\t<h2 id=\"block_a29c5943c5f11579a592db1563a1fa92-heading\" class=\"heading\">\n\t\t\t\t\t\tStudy Design and Patient Characteristics\t\t\t\t\t<\/h2>\n\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"columns wysiwyg_styles\" aria-label=\"Study Design Columns\">\n\t\t\t<div class=\"columns-2-and-3\">\n\t\t\t\t<div class=\"column-2\">\n\t\t\t\t\t<p><b><span data-contrast=\"auto\">Objective<\/span><\/b><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">A single-arm, pre-market study demonstrating the safety and performance of Shockwave IVL in heavily calcified, coronary lesions prior to stenting and followed to 6 months; also included an OCT sub-study demonstrating Shockwave IVL\u2019s mechanism of action.<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<p><b><span data-contrast=\"auto\">Primary Safety Endpoint<\/span><\/b><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">30-day major adverse cardiovascular event (MACE)<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<p><b><span data-contrast=\"auto\">Secondary Performance Endpoint<\/span><\/b><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\"><50% residual stenosis post-percutaneous coronary intervention (PCI) with no evidence of in-hospital MACE<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"column-3\">\n\t\t\t\t\t<p><b><span data-contrast=\"auto\">Patient Characteristics Summary<\/span><\/b><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"2\" data-list-defn-props=\"{\"335552541\":1,\"335559685\":720,\"335559991\":360,\"469769226\":\"Symbol\",\"469769242\":[8226],\"469777803\":\"left\",\"469777804\":\"\uf0b7\",\"469777815\":\"multilevel\"}\" aria-setsize=\"-1\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"auto\">Stable angina, unstable angina or silent ischemia<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"2\" data-list-defn-props=\"{\"335552541\":1,\"335559685\":720,\"335559991\":360,\"469769226\":\"Symbol\",\"469769242\":[8226],\"469777803\":\"left\",\"469777804\":\"\uf0b7\",\"469777815\":\"multilevel\"}\" aria-setsize=\"-1\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"auto\">Moderate and severely calcified, de novo coronary lesions right ventricular systolic dysfunction (RVD) 2.5 \u2013 4.0 mm, stenosis \u226550%, lesion length \u226432 mm<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/li>\n<\/ul>\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t<div class=\"column-1\">\n\t\t\t\t<div class=\"column-1-content\">\n\t\t\t\t\t<div class=\"column-1-content-top\">\n\t\t\t\t\t\t100% severe calcified lesions\u202f\t\t\t\t\t<\/div>\n\t\t\t\t\t<div class=\"column-1-content-bottom\">\n\t\t\t\t\t\t95% clinical success; 98.3% device success & Shockwave IVL treatment at target lesion; 100% stent delivery\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"column-1-arrow\" aria-hidden=\"true\" aria-label=\"Arrow pointing downwards to indicate result\"><i class=\"fa-regular fa-arrow-down\"><\/i><\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<div class=\"countries-section text_colors\">\n\t\t\t\t\t\t\t\t\t<div class=\"countries-header\">\n\t\t\t\t\t\t<h3 id=\"block_a29c5943c5f11579a592db1563a1fa92-countries-heading\">\n\t\t\t\t\t\t\tCountries Included in Study\t\t\t\t\t\t<\/h3>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<ul class=\"countries\" aria-labelledby=\"block_a29c5943c5f11579a592db1563a1fa92-countries-heading\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<li class=\"countries-country\">\n\t\t\t\t\t\t\t\t<img decoding=\"async\" data-src=\"https:\/\/shockwavemedical.com\/wp-content\/themes\/shockwave-med\/assets\/dist\/imgs\/country-flags\/au.png\"\n\t\t\t\t\t\t\t\t\talt=\"Flag of Australia\"\n\t\t\t\t\t\t\t\t\tclass=\"country-flag lazyload\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 2560px; --smush-placeholder-aspect-ratio: 2560\/1280;\" \/>\n\t\t\t\t\t\t\t\t<span class=\"country-name small_body\">Australia<\/span>\n\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<li class=\"countries-country\">\n\t\t\t\t\t\t\t\t<img decoding=\"async\" data-src=\"https:\/\/shockwavemedical.com\/wp-content\/themes\/shockwave-med\/assets\/dist\/imgs\/country-flags\/fr.png\"\n\t\t\t\t\t\t\t\t\talt=\"Flag of France\"\n\t\t\t\t\t\t\t\t\tclass=\"country-flag lazyload\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 2560px; --smush-placeholder-aspect-ratio: 2560\/1707;\" \/>\n\t\t\t\t\t\t\t\t<span class=\"country-name small_body\">France<\/span>\n\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<li class=\"countries-country\">\n\t\t\t\t\t\t\t\t<img decoding=\"async\" data-src=\"https:\/\/shockwavemedical.com\/wp-content\/themes\/shockwave-med\/assets\/dist\/imgs\/country-flags\/nl.png\"\n\t\t\t\t\t\t\t\t\talt=\"Flag of Netherlands\"\n\t\t\t\t\t\t\t\t\tclass=\"country-flag lazyload\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 2560px; --smush-placeholder-aspect-ratio: 2560\/1707;\" \/>\n\t\t\t\t\t\t\t\t<span class=\"country-name small_body\">Netherlands<\/span>\n\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<li class=\"countries-country\">\n\t\t\t\t\t\t\t\t<img decoding=\"async\" data-src=\"https:\/\/shockwavemedical.com\/wp-content\/themes\/shockwave-med\/assets\/dist\/imgs\/country-flags\/se.png\"\n\t\t\t\t\t\t\t\t\talt=\"Flag of Sweden\"\n\t\t\t\t\t\t\t\t\tclass=\"country-flag lazyload\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 2560px; --smush-placeholder-aspect-ratio: 2560\/1600;\" \/>\n\t\t\t\t\t\t\t\t<span class=\"country-name small_body\">Sweden<\/span>\n\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<li class=\"countries-country\">\n\t\t\t\t\t\t\t\t<img decoding=\"async\" data-src=\"https:\/\/shockwavemedical.com\/wp-content\/themes\/shockwave-med\/assets\/dist\/imgs\/country-flags\/gb.png\"\n\t\t\t\t\t\t\t\t\talt=\"Flag of United Kingdom\"\n\t\t\t\t\t\t\t\t\tclass=\"country-flag lazyload\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 2560px; --smush-placeholder-aspect-ratio: 2560\/1280;\" \/>\n\t\t\t\t\t\t\t\t<span class=\"country-name small_body\">United Kingdom<\/span>\n\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t\t\t\t<\/ul>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t<\/div>\n<\/section>\n\n<section\n\tid=\"block_6c9478c113c51fb034befae00719b442\"\n\tclass=\"block block--spacer-with-optional-divider \"\n\taria-label=\"Spacer section with optional divider\">\n\t<div class=\"spacer-with-optional-divider-container container\">\n\n\t\t<!-- Space Above -->\n\t\t<div\n\t\t\tclass=\"space-above\"\n\t\t\tstyle=\"--aboveDesktop: 60px; --aboveMobile: 30px;\"\n\t\t\taria-hidden=\"true\"\n\t\t\trole=\"presentation\">\n\t\t<\/div>\n\n\t\t<!-- Optional Divider -->\n\t\t\n\t\t<!-- Space Below -->\n\t\t<div\n\t\t\tclass=\"space-below\"\n\t\t\tstyle=\"--belowDesktop: 0px; --belowMobile: 0px;\"\n\t\t\taria-hidden=\"true\"\n\t\t\trole=\"presentation\">\n\t\t<\/div>\n\n\t<\/div>\n<\/section>\n\n\n<section id=\"block_235a9af4def7eb90e9246e5127c57201\" class=\"block block--wysiwyg wysiwyg_styles u-bgColorNone container\">\n\t<div class=\"u-wysiwyg u-animation\">\n\t\t<h2>Strong Safety and Low Complications<\/h2>\n<table style=\"border-collapse: collapse; width: 100%;\">\n<tbody>\n<tr>\n<td style=\"width: 33.3333%;\">Safety<\/td>\n<td style=\"width: 33.3333%;\">Results<\/td>\n<td style=\"width: 33.3333%;\">Events<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 33.3333%;\"><span class=\"TextRun SCXW257051864 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW257051864 BCX0\">30-day MACE* cardiac death, myocardial infarction (MI) or tricuspid valve replacement (TVR)<\/span><\/span><\/td>\n<td style=\"width: 33.3333%;\">5%<\/td>\n<td style=\"width: 33.3333%;\">Cardiac death N = 0<br \/>\nQWMI N = 0<br \/>\n**NQWMI N = 3<br \/>\nTVR N = 0<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 33.3333%;\"><span class=\"TextRun SCXW151657623 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW151657623 BCX0\">6-month MACE* cardiac death, myocardial infarction (MI) or tricuspid valve replacement (TVR)<\/span><\/span><\/td>\n<td style=\"width: 33.3333%;\">8.3%<\/td>\n<td style=\"width: 33.3333%;\">Cardiac death N = 2<br \/>\nQWMI N = 0<br \/>\n**NQWMI N = 3<br \/>\nTVR N = 0<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><span style=\"font-size: 10pt;\">Core lab adjudicated<br \/>\n*CEC adjudicated<br \/>\n**NQMI defined as 3x upper limit CK-MB\u00a0<\/span><\/p>\n<table style=\"border-collapse: collapse; width: 100%;\">\n<tbody>\n<tr>\n<td style=\"width: 33.3333%;\">Complications<\/td>\n<td style=\"width: 33.3333%;\">Procedural<\/td>\n<td style=\"width: 33.3333%;\">Final<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 33.3333%;\"><span class=\"TextRun SCXW59773750 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW59773750 BCX0\">Dissection (D \/ E \/ F)<\/span><\/span><span class=\"EOP SCXW59773750 BCX0\" data-ccp-props=\"{}\">\u00a0<\/span><\/td>\n<td style=\"width: 33.3333%;\"><span class=\"TextRun SCXW228656090 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW228656090 BCX0\">3.3% \/ 0% \/ 0%<\/span><\/span><span class=\"EOP SCXW228656090 BCX0\" data-ccp-props=\"{}\">\u00a0<\/span><\/td>\n<td style=\"width: 33.3333%;\">0% \/ 0% \/ 0%<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 33.3333%;\"><span class=\"TextRun SCXW235816563 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW235816563 BCX0\">Perforation<\/span><\/span><\/td>\n<td style=\"width: 33.3333%;\">0.0%<\/td>\n<td style=\"width: 33.3333%;\">0.0%<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 33.3333%;\"><span class=\"TextRun SCXW90039868 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW90039868 BCX0\">Abrupt closure<\/span><\/span><span class=\"EOP SCXW90039868 BCX0\" data-ccp-props=\"{}\">\u00a0<\/span><\/td>\n<td style=\"width: 33.3333%;\">0.0%<\/td>\n<td style=\"width: 33.3333%;\">0.0%<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 33.3333%;\"><span class=\"TextRun SCXW48836947 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW48836947 BCX0\">Slow flow<\/span><\/span><\/td>\n<td style=\"width: 33.3333%;\">0.0%<\/td>\n<td style=\"width: 33.3333%;\">0.0%<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 33.3333%;\"><span class=\"TextRun SCXW197111386 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW197111386 BCX0\">No reflow<\/span><\/span><\/td>\n<td style=\"width: 33.3333%;\">0.0%<\/td>\n<td style=\"width: 33.3333%;\">0.0%<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><span style=\"font-size: 10pt;\">Brinton et al 2019 in Circ Int.<\/span><\/p>\n\t<\/div>\n\t<\/section>\n\n<section\n\tid=\"block_6c9478c113c51fb034befae00719b442\"\n\tclass=\"block block--spacer-with-optional-divider \"\n\taria-label=\"Spacer section with optional divider\">\n\t<div class=\"spacer-with-optional-divider-container container\">\n\n\t\t<!-- Space Above -->\n\t\t<div\n\t\t\tclass=\"space-above\"\n\t\t\tstyle=\"--aboveDesktop: 60px; --aboveMobile: 30px;\"\n\t\t\taria-hidden=\"true\"\n\t\t\trole=\"presentation\">\n\t\t<\/div>\n\n\t\t<!-- Optional Divider -->\n\t\t\n\t\t<!-- Space Below -->\n\t\t<div\n\t\t\tclass=\"space-below\"\n\t\t\tstyle=\"--belowDesktop: 0px; --belowMobile: 0px;\"\n\t\t\taria-hidden=\"true\"\n\t\t\trole=\"presentation\">\n\t\t<\/div>\n\n\t<\/div>\n<\/section>\n\n\n<section id=\"block_878cda2209659d9612c755f34b36537d\" class=\"block block--wysiwyg wysiwyg_styles u-bgColorNone container\">\n\t<div class=\"u-wysiwyg u-animation\">\n\t\t<h2><span class=\"TextRun SCXW100753666 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW100753666 BCX0\">DISRUPT<\/span><span class=\"NormalTextRun SCXW100753666 BCX0\"> CAD I OCT Sub-Study Confirms Mechanism of Action (MOA) of <\/span><span class=\"NormalTextRun SCXW100753666 BCX0\">Shockwave <\/span><span class=\"NormalTextRun SCXW100753666 BCX0\">Intravascular Lithotripsy<\/span><\/span><span class=\"EOP SCXW100753666 BCX0\" data-ccp-props=\"{}\">\u00a0<\/span><\/h2>\n\t<\/div>\n\t<\/section>\n\n\n<section id=\"block_3f9e1b154613e1e3291f11e966a234cd\" class=\"block block--stat-callout \" role=\"region\" aria-labelledby=\"statCalloutTitle\" aria-describedby=\"statCalloutDesc\">\n\t<h2 id=\"statCalloutTitle\" class=\"sr-only\">Statistics Callout<\/h2> <!-- Add a hidden heading for accessibility -->\n\t<p id=\"statCalloutDesc\" class=\"sr-only\">This section presents key statistical information with numbers and descriptions.<\/p> <!-- Hidden description -->\n\n\t<!-- Changing container to ul for better semantics -->\n\t<ul class=\"container\" role=\"list\">\n\t\t\t\t\t\t<!-- Each card is now an li element for semantic correctness -->\n\t\t\t<li class=\"card\" id=\"block_3f9e1b154613e1e3291f11e966a234cd-card-0\" role=\"listitem\" aria-labelledby=\"block_3f9e1b154613e1e3291f11e966a234cd-card-0-number\" aria-describedby=\"block_3f9e1b154613e1e3291f11e966a234cd-card-0-description\">\n\t\t\t\t<div class=\"card-top\">\n\t\t\t\t\t\t\t\t\t\t\t<div class=\"card-number\" id=\"block_3f9e1b154613e1e3291f11e966a234cd-card-0-number\">31<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"card-symbol\">\n\t\t\t\t\t\t\t<span><\/span>\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t\t\t<div class=\"card-description font--p\" id=\"block_3f9e1b154613e1e3291f11e966a234cd-card-0-description\">\n\t\t\t\t\t\tPatients\t\t\t\t\t<\/div>\n\t\t\t\t\n\t\t\t<\/li>\n\t\t\t\t\t<!-- Each card is now an li element for semantic correctness -->\n\t\t\t<li class=\"card\" id=\"block_3f9e1b154613e1e3291f11e966a234cd-card-1\" role=\"listitem\" aria-labelledby=\"block_3f9e1b154613e1e3291f11e966a234cd-card-1-number\" aria-describedby=\"block_3f9e1b154613e1e3291f11e966a234cd-card-1-description\">\n\t\t\t\t<div class=\"card-top\">\n\t\t\t\t\t\t\t\t\t\t\t<div class=\"card-number\" id=\"block_3f9e1b154613e1e3291f11e966a234cd-card-1-number\">3<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"card-symbol\">\n\t\t\t\t\t\t\t<span><\/span>\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t\t\t<div class=\"card-description font--p\" id=\"block_3f9e1b154613e1e3291f11e966a234cd-card-1-description\">\n\t\t\t\t\t\tOCT runs: Baseline, post-IVL & post-stent\t\t\t\t\t<\/div>\n\t\t\t\t\n\t\t\t<\/li>\n\t\t\t\t\t<!-- Each card is now an li element for semantic correctness -->\n\t\t\t<li class=\"card\" id=\"block_3f9e1b154613e1e3291f11e966a234cd-card-2\" role=\"listitem\" aria-labelledby=\"block_3f9e1b154613e1e3291f11e966a234cd-card-2-number\" aria-describedby=\"block_3f9e1b154613e1e3291f11e966a234cd-card-2-description\">\n\t\t\t\t<div class=\"card-top\">\n\t\t\t\t\t\t\t\t\t\t\t<div class=\"card-number\" id=\"block_3f9e1b154613e1e3291f11e966a234cd-card-2-number\">55%<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"card-symbol\">\n\t\t\t\t\t\t\t<span><\/span>\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t\t\t<div class=\"card-description font--p\" id=\"block_3f9e1b154613e1e3291f11e966a234cd-card-2-description\">\n\t\t\t\t\t\tFracture post-stent\t\t\t\t\t<\/div>\n\t\t\t\t\n\t\t\t<\/li>\n\t\t\t\t\t<!-- Each card is now an li element for semantic correctness -->\n\t\t\t<li class=\"card\" id=\"block_3f9e1b154613e1e3291f11e966a234cd-card-3\" role=\"listitem\" aria-labelledby=\"block_3f9e1b154613e1e3291f11e966a234cd-card-3-number\" aria-describedby=\"block_3f9e1b154613e1e3291f11e966a234cd-card-3-description\">\n\t\t\t\t<div class=\"card-top\">\n\t\t\t\t\t\t\t\t\t\t\t<div class=\"card-number\" id=\"block_3f9e1b154613e1e3291f11e966a234cd-card-3-number\">2.1 mm<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"card-symbol\">\n\t\t\t\t\t\t\t<sup>2<\/sup>\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t\t\t<div class=\"card-description font--p\" id=\"block_3f9e1b154613e1e3291f11e966a234cd-card-3-description\">\n\t\t\t\t\t\tAcute area gain post-IVL\t\t\t\t\t<\/div>\n\t\t\t\t\n\t\t\t<\/li>\n\t\t\t\t\t<!-- Each card is now an li element for semantic correctness -->\n\t\t\t<li class=\"card\" id=\"block_3f9e1b154613e1e3291f11e966a234cd-card-4\" role=\"listitem\" aria-labelledby=\"block_3f9e1b154613e1e3291f11e966a234cd-card-4-number\" aria-describedby=\"block_3f9e1b154613e1e3291f11e966a234cd-card-4-description\">\n\t\t\t\t<div class=\"card-top\">\n\t\t\t\t\t\t\t\t\t\t\t<div class=\"card-number\" id=\"block_3f9e1b154613e1e3291f11e966a234cd-card-4-number\">5.9 mm<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"card-symbol\">\n\t\t\t\t\t\t\t<sup>2<\/sup>\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t\t\t<div class=\"card-description font--p\" id=\"block_3f9e1b154613e1e3291f11e966a234cd-card-4-description\">\n\t\t\t\t\t\tMinimal stent area\t\t\t\t\t<\/div>\n\t\t\t\t\n\t\t\t<\/li>\n\t\t\t\t<\/ul>\n<\/section>\n\n\n<section id=\"block_9ebf70da6ab45662ebf7d48c7ba634bc\" class=\"block block--wysiwyg wysiwyg_styles u-bgColorNone container\">\n\t<div class=\"u-wysiwyg u-animation\">\n\t\t<h3><span class=\"NormalTextRun SCXW97033746 BCX0\">Read the full <\/span><span class=\"NormalTextRun SCXW97033746 BCX0\">DISRUPT<\/span><span class=\"NormalTextRun SCXW97033746 BCX0\"> CAD I OCT sub-analysis on the JACC: Cardiovascular Imaging website:<\/span><\/h3>\n\t<\/div>\n\t<\/section>\n\n\n<!-- BLOCK CONTENT -->\n<section id=\"block_f1da812e73bd584ed4d7ca49c31a2569\"  class=\"block block--section \">\n\t<div class=\"container\">\n\t\t\n\n<a data-atom=\"button\" class=\"btn--primary\" href=\"https:\/\/imaging.onlinejacc.org\/content\/10\/8\/897\" target=\"_blank\" aria-label=\"Read the Analysis - opens in a new tab\" rel=\"noopener\">Read the Analysis<i aria-hidden=\"true\" class=\"fa-sharp fa-arrow-right fa-solid\"><\/i><\/a>\n\n\t<\/div>\n<\/section>\n\n<section\n\tid=\"block_6c9478c113c51fb034befae00719b442\"\n\tclass=\"block block--spacer-with-optional-divider \"\n\taria-label=\"Spacer section with optional divider\">\n\t<div class=\"spacer-with-optional-divider-container container\">\n\n\t\t<!-- Space Above -->\n\t\t<div\n\t\t\tclass=\"space-above\"\n\t\t\tstyle=\"--aboveDesktop: 60px; --aboveMobile: 30px;\"\n\t\t\taria-hidden=\"true\"\n\t\t\trole=\"presentation\">\n\t\t<\/div>\n\n\t\t<!-- Optional Divider -->\n\t\t\n\t\t<!-- Space Below -->\n\t\t<div\n\t\t\tclass=\"space-below\"\n\t\t\tstyle=\"--belowDesktop: 0px; --belowMobile: 0px;\"\n\t\t\taria-hidden=\"true\"\n\t\t\trole=\"presentation\">\n\t\t<\/div>\n\n\t<\/div>\n<\/section>\n\n\n<section id=\"block_47f9615db12f2c43fe923dc590c38544\" class=\"block block--wysiwyg wysiwyg_styles u-bgColorNone container\">\n\t<div class=\"u-wysiwyg u-animation\">\n\t\t<h2><span data-contrast=\"auto\">OCT Sub-Analysis Key Findings<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/h2>\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"3\" data-list-defn-props=\"{\"335552541\":1,\"335559685\":720,\"335559991\":360,\"469769226\":\"Symbol\",\"469769242\":[8226],\"469777803\":\"left\",\"469777804\":\"\uf0b7\",\"469777815\":\"hybridMultilevel\"}\" aria-setsize=\"-1\" data-aria-posinset=\"1\" data-aria-level=\"1\"><b><span data-contrast=\"auto\">Transmural fractures: <\/span><\/b><span data-contrast=\"auto\">Shockwave<\/span> <span data-contrast=\"auto\">IVL shown to fracture both intimal and medial calcium under OCT<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"3\" data-list-defn-props=\"{\"335552541\":1,\"335559685\":720,\"335559991\":360,\"469769226\":\"Symbol\",\"469769242\":[8226],\"469777803\":\"left\",\"469777804\":\"\uf0b7\",\"469777815\":\"hybridMultilevel\"}\" aria-setsize=\"-1\" data-aria-posinset=\"1\" data-aria-level=\"1\"><b><span data-contrast=\"auto\">More fractures:<\/span><\/b><span data-contrast=\"auto\"> The more severe the calcium, the greater the incidence of fracture<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"3\" data-list-defn-props=\"{\"335552541\":1,\"335559685\":720,\"335559991\":360,\"469769226\":\"Symbol\",\"469769242\":[8226],\"469777803\":\"left\",\"469777804\":\"\uf0b7\",\"469777815\":\"hybridMultilevel\"}\" aria-setsize=\"-1\" data-aria-posinset=\"1\" data-aria-level=\"1\"><b><span data-contrast=\"auto\">Improved compliance:<\/span><\/b><span data-contrast=\"auto\"> Improved vessel compliance enables similar stent expansion across all lesions, despite calcium severity<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><img decoding=\"async\" class=\"aligncenter wp-image-7284 lazyload\" data-src=\"https:\/\/shockwavemedical.com\/wp-content\/uploads\/2024\/11\/Disrupt_CAD_I_Global_and_Europe-300x217.png\" alt=\"\" width=\"1200\" height=\"867\" data-srcset=\"https:\/\/shockwavemedical.com\/wp-content\/uploads\/2024\/11\/Disrupt_CAD_I_Global_and_Europe-300x217.png 300w, https:\/\/shockwavemedical.com\/wp-content\/uploads\/2024\/11\/Disrupt_CAD_I_Global_and_Europe-1024x740.png 1024w, https:\/\/shockwavemedical.com\/wp-content\/uploads\/2024\/11\/Disrupt_CAD_I_Global_and_Europe-768x555.png 768w, https:\/\/shockwavemedical.com\/wp-content\/uploads\/2024\/11\/Disrupt_CAD_I_Global_and_Europe-1536x1110.png 1536w, https:\/\/shockwavemedical.com\/wp-content\/uploads\/2024\/11\/Disrupt_CAD_I_Global_and_Europe.png 1800w\" data-sizes=\"(max-width: 1200px) 100vw, 1200px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 1200px; --smush-placeholder-aspect-ratio: 1200\/867;\" \/><\/p>\n<p>\u00a0<\/p>\n<p style=\"text-align: center;\"><span class=\"TextRun SCXW70310394 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW70310394 BCX0\">Frames are co-registered to ensure cross-sections are in the same location.<\/span><\/span><span class=\"EOP SCXW70310394 BCX0\" data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n\t<\/div>\n\t<\/section>\n\n<section\n\tid=\"block_3414dd837eb1b7f06c4570bf91417f4a\"\n\tclass=\"block block--spacer-with-optional-divider \"\n\taria-label=\"Spacer section with optional divider\">\n\t<div class=\"spacer-with-optional-divider-container container\">\n\n\t\t<!-- Space Above -->\n\t\t<div\n\t\t\tclass=\"space-above\"\n\t\t\tstyle=\"--aboveDesktop: 0px; --aboveMobile: 0px;\"\n\t\t\taria-hidden=\"true\"\n\t\t\trole=\"presentation\">\n\t\t<\/div>\n\n\t\t<!-- Optional Divider -->\n\t\t\n\t\t<!-- Space Below -->\n\t\t<div\n\t\t\tclass=\"space-below\"\n\t\t\tstyle=\"--belowDesktop: 0px; --belowMobile: 0px;\"\n\t\t\taria-hidden=\"true\"\n\t\t\trole=\"presentation\">\n\t\t<\/div>\n\n\t<\/div>\n<\/section>\n\n<section id=\"block_fa16f0cc750f00b082afcb6f0f655f3c\" class=\"block block--featured-clinical-evidence \" aria-labelledby=\"featured-clinical-evidence-title\">\n\t\t\t<div class=\"featured-clinical-evidence--top text_colors \">\n\t\t\t<div class=\"featured-clinical-evidence--title\">\n\t\t\t\t\t\t\t\t\t<h2 id=\"featured-clinical-evidence-title\" class=\"heading\">More DISRUPT CAD Studies<\/h2>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"featured-clinical-evidence__btn-wrap featured-clinical-evidence__btn-wrap-top u--hidden u-md-block\">\n\t\t\t\t\t\t\n<a data-atom=\"button\" class=\" btn--secondary\" href=\"https:\/\/shockwavemedical.com\/en-eu\/clinical-evidence\/\" target=\"_self\" aria-label=\"See All Clinical Evidence - link to page\">See All Clinical Evidence<i aria-hidden=\"true\" class=\"fa-sharp fa-arrow-right fa-light\"><\/i><\/a>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\n\t\t\t\t\t\t\t<div class=\"featured-clinical-evidence__btn-wrap featured-clinical-evidence__btn-wrap-bottom u--block u-md-hidden\">\n\t\t\t\t\t\n<a data-atom=\"button\" class=\" btn--secondary\" href=\"https:\/\/shockwavemedical.com\/en-eu\/clinical-evidence\/\" target=\"_self\" aria-label=\"See All Clinical Evidence - link to page\">See All Clinical Evidence<i aria-hidden=\"true\" class=\"fa-sharp fa-arrow-right fa-light\"><\/i><\/a>\t\t\t\t<\/div>\n\t\t\t\n\t\t\t\t\t<\/div>\n\t\t<ul class=\"featured-clinical-evidence-list text_colors\" role=\"list\">\n\t\t\t\t\t\t<li class=\"featured-clinical-evidence-item\" role=\"listitem\" aria-labelledby=\"post-title-7999\" aria-describedby=\"post-category-7999 post-excerpt-7999\">\n\t\t\t\t\t<div class=\"featured-clinical-evidence-item--text-container\" id=\"post-title-7999\">\n\t\t\t\t\t\t<a href=\"https:\/\/shockwavemedical.com\/en-eu\/clinical-evidence\/cad-ii\/\" class=\"featured-clinical-evidence-item--title\">\n\t\t\t\t\t\t\tDISRUPT CAD II\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"featured-clinical-evidence-item--arrow\" aria-hidden=\"true\"><svg width=\"25\" height=\"27\" viewBox=\"0 0 25 27\" fill=\"none\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M3.5 26H21a2.5 2.5 0 002.5-2.5V7.875L16.625 1H6a2.5 2.5 0 00-2.5 2.5v3.75\" stroke=\"#5B6770\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\"\/><path d=\"M16 1v7.5h7.5M4.75 19.75a3.75 3.75 0 100-7.498 3.75 3.75 0 000 7.498v0zm5 1.25l-1.875-1.875\" stroke=\"#5B6770\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\"\/><\/svg><\/div>\n\t\t\t\t\t\t<div class=\"featured-clinical-evidence-item--arrow-hover\" aria-hidden=\"true\"><svg width=\"25\" height=\"27\" viewBox=\"0 0 25 27\" fill=\"none\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M3.5 26H21a2.5 2.5 0 002.5-2.5V7.875L16.625 1H6a2.5 2.5 0 00-2.5 2.5v3.75\" stroke=\"#00D2FF\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\"\/><path d=\"M16 1v7.5h7.5M4.75 19.75a3.75 3.75 0 100-7.498 3.75 3.75 0 000 7.498v0zm5 1.25l-1.875-1.875\" stroke=\"#00D2FF\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\"\/><\/svg><\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t<div class=\"featured-clinical-evidence-item--excerpt\" id=\"post-excerpt-7999\">\n\t\t\t\t\t\tEuropean post-market study confirming DISRUPT CAD I results and showing strong safety and procedural success with Shockwave coronary IVL. \t\t\t\t\t<\/div>\n\t\t\t\t\t<div class=\"featured-clinical-evidence-item--category\" id=\"post-category-7999\">\n\t\t\t\t\t\tCoronary IVL\t\t\t\t\t<\/div>\n\t\t\t\t<\/li>\n\t\t\t\t\t\t<li class=\"featured-clinical-evidence-item\" role=\"listitem\" aria-labelledby=\"post-title-8003\" aria-describedby=\"post-category-8003 post-excerpt-8003\">\n\t\t\t\t\t<div class=\"featured-clinical-evidence-item--text-container\" id=\"post-title-8003\">\n\t\t\t\t\t\t<a href=\"https:\/\/shockwavemedical.com\/en-eu\/clinical-evidence\/cad-iii\/\" class=\"featured-clinical-evidence-item--title\">\n\t\t\t\t\t\t\tDISRUPT CAD III\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"featured-clinical-evidence-item--arrow\" aria-hidden=\"true\"><svg width=\"25\" height=\"27\" viewBox=\"0 0 25 27\" fill=\"none\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M3.5 26H21a2.5 2.5 0 002.5-2.5V7.875L16.625 1H6a2.5 2.5 0 00-2.5 2.5v3.75\" stroke=\"#5B6770\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\"\/><path d=\"M16 1v7.5h7.5M4.75 19.75a3.75 3.75 0 100-7.498 3.75 3.75 0 000 7.498v0zm5 1.25l-1.875-1.875\" stroke=\"#5B6770\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\"\/><\/svg><\/div>\n\t\t\t\t\t\t<div class=\"featured-clinical-evidence-item--arrow-hover\" aria-hidden=\"true\"><svg width=\"25\" height=\"27\" viewBox=\"0 0 25 27\" fill=\"none\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M3.5 26H21a2.5 2.5 0 002.5-2.5V7.875L16.625 1H6a2.5 2.5 0 00-2.5 2.5v3.75\" stroke=\"#00D2FF\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\"\/><path d=\"M16 1v7.5h7.5M4.75 19.75a3.75 3.75 0 100-7.498 3.75 3.75 0 000 7.498v0zm5 1.25l-1.875-1.875\" stroke=\"#00D2FF\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\"\/><\/svg><\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t<div class=\"featured-clinical-evidence-item--excerpt\" id=\"post-excerpt-8003\">\n\t\t\t\t\t\tLargest and most rigorous Shockwave study showcasing the safety, effectiveness and ease of use of Shockwave coronary IVL\u202f.\t\t\t\t\t<\/div>\n\t\t\t\t\t<div class=\"featured-clinical-evidence-item--category\" id=\"post-category-8003\">\n\t\t\t\t\t\tCoronary IVL\t\t\t\t\t<\/div>\n\t\t\t\t<\/li>\n\t\t\t\t\t\t<li class=\"featured-clinical-evidence-item\" role=\"listitem\" aria-labelledby=\"post-title-8037\" aria-describedby=\"post-category-8037 post-excerpt-8037\">\n\t\t\t\t\t<div class=\"featured-clinical-evidence-item--text-container\" id=\"post-title-8037\">\n\t\t\t\t\t\t<a href=\"https:\/\/shockwavemedical.com\/en-eu\/clinical-evidence\/cad-iv\/\" class=\"featured-clinical-evidence-item--title\">\n\t\t\t\t\t\t\tDISRUPT CAD IV\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"featured-clinical-evidence-item--arrow\" aria-hidden=\"true\"><svg width=\"25\" height=\"27\" viewBox=\"0 0 25 27\" fill=\"none\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M3.5 26H21a2.5 2.5 0 002.5-2.5V7.875L16.625 1H6a2.5 2.5 0 00-2.5 2.5v3.75\" stroke=\"#5B6770\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\"\/><path d=\"M16 1v7.5h7.5M4.75 19.75a3.75 3.75 0 100-7.498 3.75 3.75 0 000 7.498v0zm5 1.25l-1.875-1.875\" stroke=\"#5B6770\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\"\/><\/svg><\/div>\n\t\t\t\t\t\t<div class=\"featured-clinical-evidence-item--arrow-hover\" aria-hidden=\"true\"><svg width=\"25\" height=\"27\" viewBox=\"0 0 25 27\" fill=\"none\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M3.5 26H21a2.5 2.5 0 002.5-2.5V7.875L16.625 1H6a2.5 2.5 0 00-2.5 2.5v3.75\" stroke=\"#00D2FF\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\"\/><path d=\"M16 1v7.5h7.5M4.75 19.75a3.75 3.75 0 100-7.498 3.75 3.75 0 000 7.498v0zm5 1.25l-1.875-1.875\" stroke=\"#00D2FF\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\"\/><\/svg><\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t<div class=\"featured-clinical-evidence-item--excerpt\" id=\"post-excerpt-8037\">\n\t\t\t\t\t\tShockwave coronary study demonstrating the safety and effectiveness of Shockwave IVL within a Japanese patient population. \t\t\t\t\t<\/div>\n\t\t\t\t\t<div class=\"featured-clinical-evidence-item--category\" id=\"post-category-8037\">\n\t\t\t\t\t\tCoronary IVL\t\t\t\t\t<\/div>\n\t\t\t\t<\/li>\n\t\t\t<\/ul>\n<\/section>\n\n\n<section\n\tid=\"block_6c9478c113c51fb034befae00719b442\"\n\tclass=\"block block--spacer-with-optional-divider \"\n\taria-label=\"Spacer section with optional divider\">\n\t<div class=\"spacer-with-optional-divider-container container\">\n\n\t\t<!-- Space Above -->\n\t\t<div\n\t\t\tclass=\"space-above\"\n\t\t\tstyle=\"--aboveDesktop: 60px; --aboveMobile: 30px;\"\n\t\t\taria-hidden=\"true\"\n\t\t\trole=\"presentation\">\n\t\t<\/div>\n\n\t\t<!-- Optional Divider -->\n\t\t\n\t\t<!-- Space Below -->\n\t\t<div\n\t\t\tclass=\"space-below\"\n\t\t\tstyle=\"--belowDesktop: 0px; --belowMobile: 0px;\"\n\t\t\taria-hidden=\"true\"\n\t\t\trole=\"presentation\">\n\t\t<\/div>\n\n\t<\/div>\n<\/section>","protected":false},"excerpt":{"rendered":"<p>Single-arm, pre-market study demonstrating the safety and performance of Shockwave IVL in heavily calcified\u202f coronary lesions.<\/p>\n","protected":false},"featured_media":4009,"template":"","format":[],"meta":{"_acf_changed":true,"content-type":""},"disease-state":[159],"product-tag":[255,251],"specialty":[295,328,332,336,344],"technology":[316],"class_list":["post-7995","clinical-evidence","type-clinical-evidence","status-publish","has-post-thumbnail","hentry","disease-state-coronary-artery-disease-en-uk","product-tag-shockwave-c2-en-uk-2","product-tag-shockwave-c2-en-uk","specialty-fellows-residents-en-uk","specialty-interventional-cardiologists-en-uk","specialty-interventional-radiologists-en-uk","specialty-nurses-technologists-en-uk","specialty-vascular-surgeons-en-uk","technology-coronary-ivl-en-uk"],"acf":[],"_links":{"self":[{"href":"https:\/\/shockwavemedical.com\/en-eu\/wp-json\/wp\/v2\/clinical-evidence\/7995","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/shockwavemedical.com\/en-eu\/wp-json\/wp\/v2\/clinical-evidence"}],"about":[{"href":"https:\/\/shockwavemedical.com\/en-eu\/wp-json\/wp\/v2\/types\/clinical-evidence"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/shockwavemedical.com\/en-eu\/wp-json\/wp\/v2\/media\/4009"}],"wp:attachment":[{"href":"https:\/\/shockwavemedical.com\/en-eu\/wp-json\/wp\/v2\/media?parent=7995"}],"wp:term":[{"taxonomy":"disease-state","embeddable":true,"href":"https:\/\/shockwavemedical.com\/en-eu\/wp-json\/wp\/v2\/disease-state?post=7995"},{"taxonomy":"format","embeddable":true,"href":"https:\/\/shockwavemedical.com\/en-eu\/wp-json\/wp\/v2\/format?post=7995"},{"taxonomy":"product-tag","embeddable":true,"href":"https:\/\/shockwavemedical.com\/en-eu\/wp-json\/wp\/v2\/product-tag?post=7995"},{"taxonomy":"specialty","embeddable":true,"href":"https:\/\/shockwavemedical.com\/en-eu\/wp-json\/wp\/v2\/specialty?post=7995"},{"taxonomy":"technology","embeddable":true,"href":"https:\/\/shockwavemedical.com\/en-eu\/wp-json\/wp\/v2\/technology?post=7995"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}