{"id":8041,"date":"2021-04-13T15:46:00","date_gmt":"2021-04-13T20:46:00","guid":{"rendered":"https:\/\/shockwavemedical.com\/clinical-evidence\/disrupt-cad-pooled\/"},"modified":"2026-04-07T12:43:45","modified_gmt":"2026-04-07T17:43:45","slug":"cad-pooled","status":"publish","type":"clinical-evidence","link":"https:\/\/shockwavemedical.com\/en-eu\/clinical-evidence\/cad-pooled\/","title":{"rendered":"DISRUPT CAD Pooled"},"content":{"rendered":"\n\n\n<section id=\"block_d8182e4b97785ccbea30a3d9a791f807\" class=\"block block--primary-header u-darkMode u-bgColor_primary shockwave\"\n\tstyle=\"--desktop-bg-image: url('https:\/\/shockwavemedical.com\/wp-content\/uploads\/2024\/11\/Background-Pulses.png');\n\t\t\t\t --mobile-bg-image: url('');\">\n\n\t<div class=\"primary-header-container text_colors\">\n\n\t\t<!-- Heading -->\n\t\t<div class=\"heading\">\n\t\t\t<h1 class=\"main-heading\">DISRUPT CAD Pooled<\/h1>\n\t\t\t<h3 class=\"sub-heading\">Patient-pooled analysis of the global DISRUPT CAD I-IV clinical program demonstrates consistently high rates of procedural success with low rates of post-IVL procedural angiographic complications of severely calcified coronary lesions treated with Shockwave IVL.<\/h3>\n\t\t<\/div>\n\n\t\t<!-- Optional links -->\n\t\t\n\t\t<!-- links - J&J -->\n\t\t\n\t\t<!-- Social share -->\n\t\t\t\t<!-- Foreground for Desktop -->\n\t\t\t\t\t<div class=\"desktop-foreground-file\">\n\t\t\t\t\t\t\t\t\t<img decoding=\"async\" data-src=\"https:\/\/shockwavemedical.com\/wp-content\/uploads\/2024\/11\/DISRUPT-CAD-POOLED-Clinical-Hero-Image-4.png\" alt=\"DISRUPT CAD POOLED logo\" role=\"img\" aria-label=\"Foreground image for desktop\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" class=\"lazyload\" style=\"--smush-placeholder-width: 955px; --smush-placeholder-aspect-ratio: 955\/970;\">\n\t\t\t\t\t\t\t<\/div>\n\t\t\n\t\t<!-- Foreground for Mobile -->\n\t\t\t\t\t<div class=\"mobile-foreground-file\">\n\t\t\t\t\t\t\t\t\t<img decoding=\"async\" data-src=\"https:\/\/shockwavemedical.com\/wp-content\/uploads\/2024\/11\/Clinical-Hero-Images-mobile-05.png\" alt=\"DISRUPT CAD Pooled logo\" role=\"img\" aria-label=\"Foreground image for mobile\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" class=\"lazyload\" style=\"--smush-placeholder-width: 814px; --smush-placeholder-aspect-ratio: 814\/401;\">\n\t\t\t\t\t\t\t<\/div>\n\t\t\t<\/div>\n<\/section>\n\n\n<section id=\"findings\" class=\"block block--content-3-or-4-up text_colors shockwave\" aria-labelledby=\"section-heading-findings\">\n\t<div class=\"container\">\n\n\t\t<!-- Header -->\n\t\t\t\t\t<header class=\"heading-row\">\n\t\t\t\t\t\t\t\t\t<h2 id=\"section-heading-findings\" class=\"optional-heading\">\n\t\t\t\t\t\tKey Findings\t\t\t\t\t<\/h2>\n\t\t\t\t\n\t\t\t\t\t\t\t<\/header>\n\t\t\n\t\t<!-- Cards Section -->\n\t\t<ul class=\"cards three-cards\" role=\"list\">\n\t\t\t\t\t\t\t<li class=\"card content-3-or-4-up-card three-cards\" role=\"listitem\">\n\t\t\t\t\t\n\t\t\t\t\t<!-- Card Content -->\n\t\t\t\t\t<div class=\"card-heading-description-link\">\n\t\t\t\t\t\t<h3 class=\"card-heading\">Shockwave IVL facilitates stent delivery with low residual stenosis<\/h3>\n\n\t\t\t\t\t\t<div class=\"card-description-link\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"card-description small_body\">High acute gain, procedural success & successful stent delivery with low residual stenosis demonstrate effective calcium modification with Shockwave IVL<\/div>\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/li>\n\t\t\t\t\t\t\t<li class=\"card content-3-or-4-up-card three-cards\" role=\"listitem\">\n\t\t\t\t\t\n\t\t\t\t\t<!-- Card Content -->\n\t\t\t\t\t<div class=\"card-heading-description-link\">\n\t\t\t\t\t\t<h3 class=\"card-heading\">Low rates of post-IVL and post-stent procedural complications<\/h3>\n\n\t\t\t\t\t\t<div class=\"card-description-link\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"card-description small_body\">The only Wavemaker with clinical evidence demonstrating low rates of procedural angiographic complications immediately following Shockwave IVL<\/div>\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/li>\n\t\t\t\t\t\t\t<li class=\"card content-3-or-4-up-card three-cards\" role=\"listitem\">\n\t\t\t\t\t\n\t\t\t\t\t<!-- Card Content -->\n\t\t\t\t\t<div class=\"card-heading-description-link\">\n\t\t\t\t\t\t<h3 class=\"card-heading\">Consistent global outcomes<\/h3>\n\n\t\t\t\t\t\t<div class=\"card-description-link\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"card-description small_body\">No statistical difference in procedural success (p=0.84) or 30-day MACE (p=0.56) across geographies studied within the DISRUPT CAD I-IV clinical program <\/div>\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/li>\n\t\t\t\t\t<\/ul>\n\t<\/div>\n<\/section>\n\n<section\n\tid=\"block_905b5b07dab65457e910b027ea3a5c03\"\n\tclass=\"block block--spacer-with-optional-divider \"\n\taria-label=\"Spacer section with optional divider\">\n\t<div class=\"spacer-with-optional-divider-container container\">\n\n\t\t<!-- Space Above -->\n\t\t<div\n\t\t\tclass=\"space-above\"\n\t\t\tstyle=\"--aboveDesktop: 30px; --aboveMobile: 20px;\"\n\t\t\taria-hidden=\"true\"\n\t\t\trole=\"presentation\">\n\t\t<\/div>\n\n\t\t<!-- Optional Divider -->\n\t\t\n\t\t<!-- Space Below -->\n\t\t<div\n\t\t\tclass=\"space-below\"\n\t\t\tstyle=\"--belowDesktop: 0px; --belowMobile: 0px;\"\n\t\t\taria-hidden=\"true\"\n\t\t\trole=\"presentation\">\n\t\t<\/div>\n\n\t<\/div>\n<\/section>\n\n\n<section id=\"design\" class=\"block block--study-design-patient-chars shockwave\" role=\"region\" aria-labelledby=\"design-heading\">\n\t<div class=\"container\">\n\t\t\t\t\t<div class=\"heading-row wysiwyg_styles\">\n\t\t\t\t\t\t\t\t\t<h2 id=\"design-heading\" class=\"heading\">\n\t\t\t\t\t\tStudy Design & Characteristics\t\t\t\t\t<\/h2>\n\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"columns wysiwyg_styles\" aria-label=\"Study Design Columns\">\n\t\t\t<div class=\"columns-2-and-3\">\n\t\t\t\t<div class=\"column-2\">\n\t\t\t\t\t<p><strong>Objective: <\/strong><\/p>\n<p>To assess the cumulative safety and effectiveness of the Shockwave Medical Coronary IVL System for the treatment of severely calcified lesions in coronary arteries<\/p>\n<p><strong>Key inclusion criteria:<\/strong><\/p>\n<ul>\n<li>Presence of fluoroscopic calcium visible on both sides of the arterial wall without cardiac motion<\/li>\n<li>Total calcified segment \u2265 15 mm that extends into the target lesion<\/li>\n<li>Intravascular imaging showing a calcium arc \u2265 270\u00b0 in at least one cross-section<\/li>\n<\/ul>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"column-3\">\n\t\t\t\t\t<p><strong>Primary safety endpoint: <\/strong><\/p>\n<p>Freedom from major adverse cardiovascular events (MACE) at 30 days<\/p>\n<p><strong>Primary effectiveness endpoint: <\/strong><\/p>\n<p>Procedural success, defined as stent delivery with residual in-stent stenosis \u226430% as assessed by the angiographic core laboratory and without in-hospital MACE<\/p>\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t<div class=\"column-1\">\n\t\t\t\t<div class=\"column-1-content\">\n\t\t\t\t\t<div class=\"column-1-content-top\">\n\t\t\t\t\t\tStudy cohort represents the largest systematic assessment of complex patients with severely calcified coronary lesions treated with Shockwave IVL.\t\t\t\t\t<\/div>\n\t\t\t\t\t<div class=\"column-1-content-bottom\">\n\t\t\t\t\t\tShockwave IVL has been evaluated as a safe and effective strategy for modification of severely calcified coronary lesions prior to stenting across geographies in the DISRUPT CAD Pooled studies.\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"column-1-arrow\" aria-hidden=\"true\" aria-label=\"Arrow pointing downwards to indicate result\"><i class=\"fa-regular fa-arrow-down\"><\/i><\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<div class=\"countries-section text_colors\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<ul class=\"countries\" aria-labelledby=\"design-countries-heading\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<li class=\"countries-country\">\n\t\t\t\t\t\t\t\t<img decoding=\"async\" data-src=\"https:\/\/shockwavemedical.com\/wp-content\/themes\/shockwave-med\/assets\/dist\/imgs\/country-flags\/au.png\"\n\t\t\t\t\t\t\t\t\talt=\"Flag of Australia\"\n\t\t\t\t\t\t\t\t\tclass=\"country-flag lazyload\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 2560px; --smush-placeholder-aspect-ratio: 2560\/1280;\" \/>\n\t\t\t\t\t\t\t\t<span class=\"country-name small_body\">Australia<\/span>\n\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<li class=\"countries-country\">\n\t\t\t\t\t\t\t\t<img decoding=\"async\" data-src=\"https:\/\/shockwavemedical.com\/wp-content\/themes\/shockwave-med\/assets\/dist\/imgs\/country-flags\/be.png\"\n\t\t\t\t\t\t\t\t\talt=\"Flag of Belgium\"\n\t\t\t\t\t\t\t\t\tclass=\"country-flag lazyload\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 2560px; --smush-placeholder-aspect-ratio: 2560\/2219;\" \/>\n\t\t\t\t\t\t\t\t<span class=\"country-name small_body\">Belgium<\/span>\n\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<li class=\"countries-country\">\n\t\t\t\t\t\t\t\t<img decoding=\"async\" data-src=\"https:\/\/shockwavemedical.com\/wp-content\/themes\/shockwave-med\/assets\/dist\/imgs\/country-flags\/dk.png\"\n\t\t\t\t\t\t\t\t\talt=\"Flag of Denmark\"\n\t\t\t\t\t\t\t\t\tclass=\"country-flag lazyload\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 2560px; --smush-placeholder-aspect-ratio: 2560\/1937;\" \/>\n\t\t\t\t\t\t\t\t<span class=\"country-name small_body\">Denmark<\/span>\n\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<li class=\"countries-country\">\n\t\t\t\t\t\t\t\t<img decoding=\"async\" data-src=\"https:\/\/shockwavemedical.com\/wp-content\/themes\/shockwave-med\/assets\/dist\/imgs\/country-flags\/fr.png\"\n\t\t\t\t\t\t\t\t\talt=\"Flag of France\"\n\t\t\t\t\t\t\t\t\tclass=\"country-flag lazyload\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 2560px; --smush-placeholder-aspect-ratio: 2560\/1707;\" \/>\n\t\t\t\t\t\t\t\t<span class=\"country-name small_body\">France<\/span>\n\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<li class=\"countries-country\">\n\t\t\t\t\t\t\t\t<img decoding=\"async\" data-src=\"https:\/\/shockwavemedical.com\/wp-content\/themes\/shockwave-med\/assets\/dist\/imgs\/country-flags\/de.png\"\n\t\t\t\t\t\t\t\t\talt=\"Flag of Germany\"\n\t\t\t\t\t\t\t\t\tclass=\"country-flag lazyload\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 2560px; --smush-placeholder-aspect-ratio: 2560\/1536;\" \/>\n\t\t\t\t\t\t\t\t<span class=\"country-name small_body\">Germany<\/span>\n\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<li class=\"countries-country\">\n\t\t\t\t\t\t\t\t<img decoding=\"async\" data-src=\"https:\/\/shockwavemedical.com\/wp-content\/themes\/shockwave-med\/assets\/dist\/imgs\/country-flags\/it.png\"\n\t\t\t\t\t\t\t\t\talt=\"Flag of Italy\"\n\t\t\t\t\t\t\t\t\tclass=\"country-flag lazyload\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 2560px; --smush-placeholder-aspect-ratio: 2560\/1707;\" \/>\n\t\t\t\t\t\t\t\t<span class=\"country-name small_body\">Italy<\/span>\n\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<li class=\"countries-country\">\n\t\t\t\t\t\t\t\t<img decoding=\"async\" data-src=\"https:\/\/shockwavemedical.com\/wp-content\/themes\/shockwave-med\/assets\/dist\/imgs\/country-flags\/jp.png\"\n\t\t\t\t\t\t\t\t\talt=\"Flag of Japan\"\n\t\t\t\t\t\t\t\t\tclass=\"country-flag lazyload\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 2560px; --smush-placeholder-aspect-ratio: 2560\/1707;\" \/>\n\t\t\t\t\t\t\t\t<span class=\"country-name small_body\">Japan<\/span>\n\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<li class=\"countries-country\">\n\t\t\t\t\t\t\t\t<img decoding=\"async\" data-src=\"https:\/\/shockwavemedical.com\/wp-content\/themes\/shockwave-med\/assets\/dist\/imgs\/country-flags\/nl.png\"\n\t\t\t\t\t\t\t\t\talt=\"Flag of Netherlands\"\n\t\t\t\t\t\t\t\t\tclass=\"country-flag lazyload\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 2560px; --smush-placeholder-aspect-ratio: 2560\/1707;\" \/>\n\t\t\t\t\t\t\t\t<span class=\"country-name small_body\">Netherlands<\/span>\n\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<li class=\"countries-country\">\n\t\t\t\t\t\t\t\t<img decoding=\"async\" data-src=\"https:\/\/shockwavemedical.com\/wp-content\/themes\/shockwave-med\/assets\/dist\/imgs\/country-flags\/es.png\"\n\t\t\t\t\t\t\t\t\talt=\"Flag of Spain\"\n\t\t\t\t\t\t\t\t\tclass=\"country-flag lazyload\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 2560px; --smush-placeholder-aspect-ratio: 2560\/1707;\" \/>\n\t\t\t\t\t\t\t\t<span class=\"country-name small_body\">Spain<\/span>\n\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<li class=\"countries-country\">\n\t\t\t\t\t\t\t\t<img decoding=\"async\" data-src=\"https:\/\/shockwavemedical.com\/wp-content\/themes\/shockwave-med\/assets\/dist\/imgs\/country-flags\/se.png\"\n\t\t\t\t\t\t\t\t\talt=\"Flag of Sweden\"\n\t\t\t\t\t\t\t\t\tclass=\"country-flag lazyload\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 2560px; --smush-placeholder-aspect-ratio: 2560\/1600;\" \/>\n\t\t\t\t\t\t\t\t<span class=\"country-name small_body\">Sweden<\/span>\n\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<li class=\"countries-country\">\n\t\t\t\t\t\t\t\t<img decoding=\"async\" data-src=\"https:\/\/shockwavemedical.com\/wp-content\/themes\/shockwave-med\/assets\/dist\/imgs\/country-flags\/gb.png\"\n\t\t\t\t\t\t\t\t\talt=\"Flag of United Kingdom\"\n\t\t\t\t\t\t\t\t\tclass=\"country-flag lazyload\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 2560px; --smush-placeholder-aspect-ratio: 2560\/1280;\" \/>\n\t\t\t\t\t\t\t\t<span class=\"country-name small_body\">United Kingdom<\/span>\n\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<li class=\"countries-country\">\n\t\t\t\t\t\t\t\t<img decoding=\"async\" data-src=\"https:\/\/shockwavemedical.com\/wp-content\/themes\/shockwave-med\/assets\/dist\/imgs\/country-flags\/us.png\"\n\t\t\t\t\t\t\t\t\talt=\"Flag of United States\"\n\t\t\t\t\t\t\t\t\tclass=\"country-flag lazyload\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 2560px; --smush-placeholder-aspect-ratio: 2560\/1347;\" \/>\n\t\t\t\t\t\t\t\t<span class=\"country-name small_body\">United States<\/span>\n\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t\t\t\t<\/ul>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t<\/div>\n<\/section>\n\n\n<section id=\"block_3c682d2d3c408d515d79b6a3fa56323d\" class=\"block block--stat-callout \" role=\"region\" aria-labelledby=\"statCalloutTitle\" aria-describedby=\"statCalloutDesc\">\n\t<h2 id=\"statCalloutTitle\" class=\"sr-only\">Statistics Callout<\/h2> <!-- Add a hidden heading for accessibility -->\n\t<p id=\"statCalloutDesc\" class=\"sr-only\">This section presents key statistical information with numbers and descriptions.<\/p> <!-- Hidden description -->\n\n\t<!-- Changing container to ul for better semantics -->\n\t<ul class=\"container\" role=\"list\">\n\t\t\t\t\t\t<!-- Each card is now an li element for semantic correctness -->\n\t\t\t<li class=\"card\" id=\"block_3c682d2d3c408d515d79b6a3fa56323d-card-0\" role=\"listitem\" aria-labelledby=\"block_3c682d2d3c408d515d79b6a3fa56323d-card-0-number\" aria-describedby=\"block_3c682d2d3c408d515d79b6a3fa56323d-card-0-description\">\n\t\t\t\t<div class=\"card-top\">\n\t\t\t\t\t\t\t\t\t\t\t<div class=\"card-number\" id=\"block_3c682d2d3c408d515d79b6a3fa56323d-card-0-number\">628<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"card-symbol\">\n\t\t\t\t\t\t\t<span><\/span>\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t\t\t<div class=\"card-description font--p\" id=\"block_3c682d2d3c408d515d79b6a3fa56323d-card-0-description\">\n\t\t\t\t\t\tPatients\t\t\t\t\t<\/div>\n\t\t\t\t\n\t\t\t<\/li>\n\t\t\t\t\t<!-- Each card is now an li element for semantic correctness -->\n\t\t\t<li class=\"card\" id=\"block_3c682d2d3c408d515d79b6a3fa56323d-card-1\" role=\"listitem\" aria-labelledby=\"block_3c682d2d3c408d515d79b6a3fa56323d-card-1-number\" aria-describedby=\"block_3c682d2d3c408d515d79b6a3fa56323d-card-1-description\">\n\t\t\t\t<div class=\"card-top\">\n\t\t\t\t\t\t\t\t\t\t\t<div class=\"card-number\" id=\"block_3c682d2d3c408d515d79b6a3fa56323d-card-1-number\">72<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"card-symbol\">\n\t\t\t\t\t\t\t<span><\/span>\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t\t\t<div class=\"card-description font--p\" id=\"block_3c682d2d3c408d515d79b6a3fa56323d-card-1-description\">\n\t\t\t\t\t\tSites\t\t\t\t\t<\/div>\n\t\t\t\t\n\t\t\t<\/li>\n\t\t\t\t\t<!-- Each card is now an li element for semantic correctness -->\n\t\t\t<li class=\"card\" id=\"block_3c682d2d3c408d515d79b6a3fa56323d-card-2\" role=\"listitem\" aria-labelledby=\"block_3c682d2d3c408d515d79b6a3fa56323d-card-2-number\" aria-describedby=\"block_3c682d2d3c408d515d79b6a3fa56323d-card-2-description\">\n\t\t\t\t<div class=\"card-top\">\n\t\t\t\t\t\t\t\t\t\t\t<div class=\"card-number\" id=\"block_3c682d2d3c408d515d79b6a3fa56323d-card-2-number\">12<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"card-symbol\">\n\t\t\t\t\t\t\t<span><\/span>\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t\t\t<div class=\"card-description font--p\" id=\"block_3c682d2d3c408d515d79b6a3fa56323d-card-2-description\">\n\t\t\t\t\t\tCountries\t\t\t\t\t<\/div>\n\t\t\t\t\n\t\t\t<\/li>\n\t\t\t\t<\/ul>\n<\/section>\n\n\n<section id=\"block_b2a7cdc69a3e987509b4636388d0bace\" class=\"block block--stat-callout shockwave\" role=\"region\" aria-labelledby=\"statCalloutTitle\" aria-describedby=\"statCalloutDesc\">\n\t<h2 id=\"statCalloutTitle\" class=\"sr-only\">Statistics Callout<\/h2> <!-- Add a hidden heading for accessibility -->\n\t<p id=\"statCalloutDesc\" class=\"sr-only\">This section presents key statistical information with numbers and descriptions.<\/p> <!-- Hidden description -->\n\n\t<!-- Changing container to ul for better semantics -->\n\t<ul class=\"container\" role=\"list\">\n\t\t\t\t\t\t<!-- Each card is now an li element for semantic correctness -->\n\t\t\t<li class=\"card\" id=\"block_b2a7cdc69a3e987509b4636388d0bace-card-0\" role=\"listitem\" aria-labelledby=\"block_b2a7cdc69a3e987509b4636388d0bace-card-0-number\" aria-describedby=\"block_b2a7cdc69a3e987509b4636388d0bace-card-0-description\">\n\t\t\t\t<div class=\"card-top\">\n\t\t\t\t\t\t\t\t\t\t\t<div class=\"card-number\" id=\"block_b2a7cdc69a3e987509b4636388d0bace-card-0-number\">97<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"card-symbol\">\n\t\t\t\t\t\t\t<span>%<\/span>\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t\t\t<div class=\"card-description font--p\" id=\"block_b2a7cdc69a3e987509b4636388d0bace-card-0-description\">\n\t\t\t\t\t\tSevere calcium\t\t\t\t\t<\/div>\n\t\t\t\t\n\t\t\t<\/li>\n\t\t\t\t\t<!-- Each card is now an li element for semantic correctness -->\n\t\t\t<li class=\"card\" id=\"block_b2a7cdc69a3e987509b4636388d0bace-card-1\" role=\"listitem\" aria-labelledby=\"block_b2a7cdc69a3e987509b4636388d0bace-card-1-number\" aria-describedby=\"block_b2a7cdc69a3e987509b4636388d0bace-card-1-description\">\n\t\t\t\t<div class=\"card-top\">\n\t\t\t\t\t\t\t\t\t\t\t<div class=\"card-number\" id=\"block_b2a7cdc69a3e987509b4636388d0bace-card-1-number\">42<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"card-symbol\">\n\t\t\t\t\t\t\t<span>mm<\/span>\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t\t\t<div class=\"card-description font--p\" id=\"block_b2a7cdc69a3e987509b4636388d0bace-card-1-description\">\n\t\t\t\t\t\tCalcium length\t\t\t\t\t<\/div>\n\t\t\t\t\n\t\t\t<\/li>\n\t\t\t\t\t<!-- Each card is now an li element for semantic correctness -->\n\t\t\t<li class=\"card\" id=\"block_b2a7cdc69a3e987509b4636388d0bace-card-2\" role=\"listitem\" aria-labelledby=\"block_b2a7cdc69a3e987509b4636388d0bace-card-2-number\" aria-describedby=\"block_b2a7cdc69a3e987509b4636388d0bace-card-2-description\">\n\t\t\t\t<div class=\"card-top\">\n\t\t\t\t\t\t\t\t\t\t\t<div class=\"card-number\" id=\"block_b2a7cdc69a3e987509b4636388d0bace-card-2-number\">99<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"card-symbol\">\n\t\t\t\t\t\t\t<span>%<\/span>\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t\t\t<div class=\"card-description font--p\" id=\"block_b2a7cdc69a3e987509b4636388d0bace-card-2-description\">\n\t\t\t\t\t\tShockwave IVL crossing & therapy delivery\t\t\t\t\t<\/div>\n\t\t\t\t\n\t\t\t<\/li>\n\t\t\t\t\t<!-- Each card is now an li element for semantic correctness -->\n\t\t\t<li class=\"card\" id=\"block_b2a7cdc69a3e987509b4636388d0bace-card-3\" role=\"listitem\" aria-labelledby=\"block_b2a7cdc69a3e987509b4636388d0bace-card-3-number\" aria-describedby=\"block_b2a7cdc69a3e987509b4636388d0bace-card-3-description\">\n\t\t\t\t<div class=\"card-top\">\n\t\t\t\t\t\t\t\t\t\t\t<div class=\"card-number\" id=\"block_b2a7cdc69a3e987509b4636388d0bace-card-3-number\">12<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"card-symbol\">\n\t\t\t\t\t\t\t<span>%<\/span>\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t\t\t<div class=\"card-description font--p\" id=\"block_b2a7cdc69a3e987509b4636388d0bace-card-3-description\">\n\t\t\t\t\t\tResidual stenosis*\t\t\t\t\t<\/div>\n\t\t\t\t\n\t\t\t<\/li>\n\t\t\t\t\t<!-- Each card is now an li element for semantic correctness -->\n\t\t\t<li class=\"card\" id=\"block_b2a7cdc69a3e987509b4636388d0bace-card-4\" role=\"listitem\" aria-labelledby=\"block_b2a7cdc69a3e987509b4636388d0bace-card-4-number\" aria-describedby=\"block_b2a7cdc69a3e987509b4636388d0bace-card-4-description\">\n\t\t\t\t<div class=\"card-top\">\n\t\t\t\t\t\t\t\t\t\t\t<div class=\"card-number\" id=\"block_b2a7cdc69a3e987509b4636388d0bace-card-4-number\">92.4<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"card-symbol\">\n\t\t\t\t\t\t\t<span>%<\/span>\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t\t\t<div class=\"card-description font--p\" id=\"block_b2a7cdc69a3e987509b4636388d0bace-card-4-description\">\n\t\t\t\t\t\tProcedural success\t\t\t\t\t<\/div>\n\t\t\t\t\n\t\t\t<\/li>\n\t\t\t\t\t<!-- Each card is now an li element for semantic correctness -->\n\t\t\t<li class=\"card\" id=\"block_b2a7cdc69a3e987509b4636388d0bace-card-5\" role=\"listitem\" aria-labelledby=\"block_b2a7cdc69a3e987509b4636388d0bace-card-5-number\" aria-describedby=\"block_b2a7cdc69a3e987509b4636388d0bace-card-5-description\">\n\t\t\t\t<div class=\"card-top\">\n\t\t\t\t\t\t\t\t\t\t\t<div class=\"card-number\" id=\"block_b2a7cdc69a3e987509b4636388d0bace-card-5-number\">99<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"card-symbol\">\n\t\t\t\t\t\t\t<span>%<\/span>\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t\t\t<div class=\"card-description font--p\" id=\"block_b2a7cdc69a3e987509b4636388d0bace-card-5-description\">\n\t\t\t\t\t\tSuccessful Shockwave IVL delivery\t\t\t\t\t<\/div>\n\t\t\t\t\n\t\t\t<\/li>\n\t\t\t\t\t<!-- Each card is now an li element for semantic correctness -->\n\t\t\t<li class=\"card\" id=\"block_b2a7cdc69a3e987509b4636388d0bace-card-6\" role=\"listitem\" aria-labelledby=\"block_b2a7cdc69a3e987509b4636388d0bace-card-6-number\" aria-describedby=\"block_b2a7cdc69a3e987509b4636388d0bace-card-6-description\">\n\t\t\t\t<div class=\"card-top\">\n\t\t\t\t\t\t\t\t\t\t\t<div class=\"card-number\" id=\"block_b2a7cdc69a3e987509b4636388d0bace-card-6-number\">0.3<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"card-symbol\">\n\t\t\t\t\t\t\t<span>%<\/span>\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t\t\t<div class=\"card-description font--p\" id=\"block_b2a7cdc69a3e987509b4636388d0bace-card-6-description\">\n\t\t\t\t\t\tSerious angiographic complications*\t\t\t\t\t<\/div>\n\t\t\t\t\n\t\t\t<\/li>\n\t\t\t\t\t<!-- Each card is now an li element for semantic correctness -->\n\t\t\t<li class=\"card\" id=\"block_b2a7cdc69a3e987509b4636388d0bace-card-7\" role=\"listitem\" aria-labelledby=\"block_b2a7cdc69a3e987509b4636388d0bace-card-7-number\" aria-describedby=\"block_b2a7cdc69a3e987509b4636388d0bace-card-7-description\">\n\t\t\t\t<div class=\"card-top\">\n\t\t\t\t\t\t\t\t\t\t\t<div class=\"card-number\" id=\"block_b2a7cdc69a3e987509b4636388d0bace-card-7-number\">1.7<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"card-symbol\">\n\t\t\t\t\t\t\t<span>mm<\/span>\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t\t\t<div class=\"card-description font--p\" id=\"block_b2a7cdc69a3e987509b4636388d0bace-card-7-description\">\n\t\t\t\t\t\tAcute luminal gain*\t\t\t\t\t<\/div>\n\t\t\t\t\n\t\t\t<\/li>\n\t\t\t\t<\/ul>\n<\/section>\n\n<section\n\tid=\"outcomes\"\n\tclass=\"block block--spacer-with-optional-divider \"\n\taria-label=\"Spacer section with optional divider\">\n\t<div class=\"spacer-with-optional-divider-container container\">\n\n\t\t<!-- Space Above -->\n\t\t<div\n\t\t\tclass=\"space-above\"\n\t\t\tstyle=\"--aboveDesktop: 60px; --aboveMobile: 30px;\"\n\t\t\taria-hidden=\"true\"\n\t\t\trole=\"presentation\">\n\t\t<\/div>\n\n\t\t<!-- Optional Divider -->\n\t\t\n\t\t<!-- Space Below -->\n\t\t<div\n\t\t\tclass=\"space-below\"\n\t\t\tstyle=\"--belowDesktop: 0px; --belowMobile: 0px;\"\n\t\t\taria-hidden=\"true\"\n\t\t\trole=\"presentation\">\n\t\t<\/div>\n\n\t<\/div>\n<\/section>\n\n\n<section id=\"block_bef44f96068dabe7e05d30dbd0943c3b\" class=\"block block--wysiwyg wysiwyg_styles u-bgColorNone shockwave container\">\n\t<div class=\"u-wysiwyg u-animation\">\n\t\t<h2>Low Rates of Post-IVL & Post-Stent Procedural Complications<\/h2>\n<p>Shockwave Medical is the only Wavemaker with published post-IVL procedural outcomes demonstrating the first-in-class safety of Shockwave IVL.<\/p>\n<h3 style=\"text-align: center;\">Event Rate Across the DISRUPT CAD Studies<\/h3>\n<div id=\"attachment_13875\" style=\"width: 1410px\" class=\"wp-caption aligncenter\"><img decoding=\"async\" aria-describedby=\"caption-attachment-13875\" class=\"wp-image-13875 lazyload\" data-src=\"https:\/\/shockwavemedical.com\/wp-content\/uploads\/2026\/04\/DISRUPT-CAD-Pooled-Event-Rates-Bar-Chart-300x151.png\" alt=\"Bar chart showing the event rate of any angiographic complications, flow-limiting dissections, perforations, abrupt closures, slow flows, and no-reflows across the DISRUPT CAD studies\" width=\"1400\" height=\"705\" data-srcset=\"https:\/\/shockwavemedical.com\/wp-content\/uploads\/2026\/04\/DISRUPT-CAD-Pooled-Event-Rates-Bar-Chart-300x151.png 300w, https:\/\/shockwavemedical.com\/wp-content\/uploads\/2026\/04\/DISRUPT-CAD-Pooled-Event-Rates-Bar-Chart-1024x516.png 1024w, https:\/\/shockwavemedical.com\/wp-content\/uploads\/2026\/04\/DISRUPT-CAD-Pooled-Event-Rates-Bar-Chart-768x387.png 768w, https:\/\/shockwavemedical.com\/wp-content\/uploads\/2026\/04\/DISRUPT-CAD-Pooled-Event-Rates-Bar-Chart-1536x773.png 1536w, https:\/\/shockwavemedical.com\/wp-content\/uploads\/2026\/04\/DISRUPT-CAD-Pooled-Event-Rates-Bar-Chart.png 2000w\" data-sizes=\"(max-width: 1400px) 100vw, 1400px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 1400px; --smush-placeholder-aspect-ratio: 1400\/705;\" \/><p id=\"caption-attachment-13875\" class=\"wp-caption-text\">Immediately following IVL treatment (n = 561) and post-stent (n = 628) demonstrated a low rate of flow-limiting dissections (grade D or greater) with no perforation, abrupt closure, or no-reflow events following IVL treatment. Core laboratory assessed.<\/p><\/div>\n<h2>Shockwave IVL Facilitates Stent Delivery with Low Residual Stenosis Within Severe Calcium<\/h2>\n<p>Shockwave IVL increased minimal luminal diameter (MLD) and improved diameter stenosis immediately following therapy.<\/p>\n<h3 style=\"text-align: center;\">Procedural Angiographic Outcomes Following IVL Treatment<\/h3>\n<div id=\"attachment_13871\" style=\"width: 1610px\" class=\"wp-caption aligncenter\"><img decoding=\"async\" aria-describedby=\"caption-attachment-13871\" class=\"wp-image-13871 lazyload\" data-src=\"https:\/\/shockwavemedical.com\/wp-content\/uploads\/2026\/04\/DISRUPT-CAD-Pooled-Procedural-Angiographic-Outcomes-Charts-300x126.png\" alt=\"Graphic of two charts showing the procedural angiographic outcomes following IVL treatment. Chart one is a line chart of the cumulative frequency; chart two is a bar chart of the diameter stenosis pre-procedure, post-IVL, and post-stent\" width=\"1600\" height=\"672\" data-srcset=\"https:\/\/shockwavemedical.com\/wp-content\/uploads\/2026\/04\/DISRUPT-CAD-Pooled-Procedural-Angiographic-Outcomes-Charts-300x126.png 300w, https:\/\/shockwavemedical.com\/wp-content\/uploads\/2026\/04\/DISRUPT-CAD-Pooled-Procedural-Angiographic-Outcomes-Charts-1024x430.png 1024w, https:\/\/shockwavemedical.com\/wp-content\/uploads\/2026\/04\/DISRUPT-CAD-Pooled-Procedural-Angiographic-Outcomes-Charts-768x323.png 768w, https:\/\/shockwavemedical.com\/wp-content\/uploads\/2026\/04\/DISRUPT-CAD-Pooled-Procedural-Angiographic-Outcomes-Charts-1536x645.png 1536w, https:\/\/shockwavemedical.com\/wp-content\/uploads\/2026\/04\/DISRUPT-CAD-Pooled-Procedural-Angiographic-Outcomes-Charts.png 2000w\" data-sizes=\"(max-width: 1600px) 100vw, 1600px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 1600px; --smush-placeholder-aspect-ratio: 1600\/672;\" \/><p id=\"caption-attachment-13871\" class=\"wp-caption-text\">Core laboratory-assessed minimum luminal diameter cumulative frequency curves demonstrate an increase in minimal lumen diameter (MLD) immediately following Intravascular Lithotripsy (IVL) treatment with further increase post-stent. Core laboratory-assessed diameter stenosis demonstrates a significant decrease in diameter stenosis immediately following IVL treatment (p<0.0001) and post-stent (p<0.0001). For MLD and diameter stenosis measurements, pre-procedure n=625, post-IVL n=555, and post-stent n=625. Post-stent assessments of MLD and diameter stenosis include post-dilation in 94.1% of patients.<\/p><\/div>\n<h2>Consistently High Procedural Success & Low 30-day MACE Globally<\/h2>\n<p>The DISRUPT CAD Pooled analysis saw no statistical difference in procedural success and 30-day MACE across geographies. 30-day MACE was driven by non-Q-wave myocardial infarction (MI).<\/p>\n<h3 style=\"text-align: center;\">Safety & Effectiveness Across the DISRUPT CAD Studies<\/h3>\n<div id=\"attachment_13879\" style=\"width: 1610px\" class=\"wp-caption aligncenter\"><img decoding=\"async\" aria-describedby=\"caption-attachment-13879\" class=\"wp-image-13879 lazyload\" data-src=\"https:\/\/shockwavemedical.com\/wp-content\/uploads\/2026\/04\/DISRUPT-CAD-Pooled-Safety-Effectiveness-Across-CAD-Studies-Bar-Chart-300x122.png\" alt=\"Graphic of two bar charts showing the safety and effectiveness of IVL across the DISRUPT CAD studies. Bar chart one shows the 30-day MACE rate percentage; bar chart two shows the procedural success percentage\" width=\"1600\" height=\"651\" data-srcset=\"https:\/\/shockwavemedical.com\/wp-content\/uploads\/2026\/04\/DISRUPT-CAD-Pooled-Safety-Effectiveness-Across-CAD-Studies-Bar-Chart-300x122.png 300w, https:\/\/shockwavemedical.com\/wp-content\/uploads\/2026\/04\/DISRUPT-CAD-Pooled-Safety-Effectiveness-Across-CAD-Studies-Bar-Chart-1024x417.png 1024w, https:\/\/shockwavemedical.com\/wp-content\/uploads\/2026\/04\/DISRUPT-CAD-Pooled-Safety-Effectiveness-Across-CAD-Studies-Bar-Chart-768x313.png 768w, https:\/\/shockwavemedical.com\/wp-content\/uploads\/2026\/04\/DISRUPT-CAD-Pooled-Safety-Effectiveness-Across-CAD-Studies-Bar-Chart-1536x625.png 1536w, https:\/\/shockwavemedical.com\/wp-content\/uploads\/2026\/04\/DISRUPT-CAD-Pooled-Safety-Effectiveness-Across-CAD-Studies-Bar-Chart.png 2000w\" data-sizes=\"(max-width: 1600px) 100vw, 1600px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 1600px; --smush-placeholder-aspect-ratio: 1600\/651;\" \/><p id=\"caption-attachment-13879\" class=\"wp-caption-text\">DISRUPT CAD major adverse cardiovascular event (MACE) rates at 30 days and procedural success, defined as successful stent delivery with in-stent residual stenosis \u226430% (core laboratory assessed) without in-hospital MACE, demonstrated consistent outcomes among the individual DISRUPT CAD studies. Heterogeneity among studies was evaluated using logistic regression with study as a fixed effect. All p values were not statistically significant, indicating consistency across the four studies for 30-day MACE (p = 0.56) and procedural success (p = 0.84). AUS = Australia; EU = Europe; US = United States.<\/p><\/div>\n\t<\/div>\n\t<\/section>\n\n<section\n\tid=\"block_45fd332db4fa8593a701b2a49b5d4056\"\n\tclass=\"block block--spacer-with-optional-divider \"\n\taria-label=\"Spacer section with optional divider\">\n\t<div class=\"spacer-with-optional-divider-container container\">\n\n\t\t<!-- Space Above -->\n\t\t<div\n\t\t\tclass=\"space-above\"\n\t\t\tstyle=\"--aboveDesktop: 60px; --aboveMobile: 30px;\"\n\t\t\taria-hidden=\"true\"\n\t\t\trole=\"presentation\">\n\t\t<\/div>\n\n\t\t<!-- Optional Divider -->\n\t\t\n\t\t<!-- Space Below -->\n\t\t<div\n\t\t\tclass=\"space-below\"\n\t\t\tstyle=\"--belowDesktop: 0px; --belowMobile: 0px;\"\n\t\t\taria-hidden=\"true\"\n\t\t\trole=\"presentation\">\n\t\t<\/div>\n\n\t<\/div>\n<\/section>\n\n\n<section id=\"block_669c8c2876eae8421f75eb0febebd722\" class=\"block block--cta-button-bar text_colors \">\n\t<div class=\"cta-button-bar--container\">\n\t\t<h2 id=\"block_669c8c2876eae8421f75eb0febebd722-heading\" class=\"heading\">\n\t\t\tRead the complete DISRUPT CAD Pooled Study results.\t\t<\/h2>\n\t\t<div class=\"buttons\">\n\t\t\t\t\t\t\t<ul class=\"cta-button-bar--links-container\" role=\"list\" aria-label=\"Call-to-action buttons\">\n\t\t\t\t\t\t\t\t\t\t\t<li class=\"resource-list--link\" role=\"listitem\">\n\t\t\t\t\t\t\t\n<a data-atom=\"button\" class=\"on-blue btn--primary\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33939604\/\" target=\"_blank\" aria-label=\"Read now - opens in a new tab\" rel=\"noopener\">Read now<i aria-hidden=\"true\" class=\"fa-sharp fa-arrow-right fa-solid\"><\/i><\/a>\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t\t<\/ul>\n\t\t\t\t\t<\/div>\n\t<\/div>\n<\/section>\n\n<section id=\"block_8f203823a0689bcba0f31b38aeed20b0\" class=\"block block--featured-clinical-evidence \" aria-labelledby=\"featured-clinical-evidence-title\">\n\t\t\t<div class=\"featured-clinical-evidence--top text_colors \">\n\t\t\t<div class=\"featured-clinical-evidence--title\">\n\t\t\t\t\t\t\t\t\t<h2 id=\"featured-clinical-evidence-title\" class=\"heading\">More from the DISRUPT CAD Studies<\/h2>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"featured-clinical-evidence__btn-wrap featured-clinical-evidence__btn-wrap-top u--hidden u-md-block\">\n\t\t\t\t\t\t\n<a data-atom=\"button\" class=\" btn--secondary\" href=\"https:\/\/shockwavemedical.com\/en-eu\/clinical-evidence\/?disease-state_terms%5B%5D=coronary-artery-disease&amp;sort_order=date_desc&amp;pageNumber=1\" target=\"_self\" aria-label=\"Explore more - link to page\">Explore more<i aria-hidden=\"true\" class=\"fa-sharp fa-arrow-right fa-light\"><\/i><\/a>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\n\t\t\t\t\t\t\t<div class=\"featured-clinical-evidence__btn-wrap featured-clinical-evidence__btn-wrap-bottom u--block u-md-hidden\">\n\t\t\t\t\t\n<a data-atom=\"button\" class=\" btn--secondary\" href=\"https:\/\/shockwavemedical.com\/en-eu\/clinical-evidence\/?disease-state_terms%5B%5D=coronary-artery-disease&amp;sort_order=date_desc&amp;pageNumber=1\" target=\"_self\" aria-label=\"Explore more - link to page\">Explore more<i aria-hidden=\"true\" class=\"fa-sharp fa-arrow-right fa-light\"><\/i><\/a>\t\t\t\t<\/div>\n\t\t\t\n\t\t\t\t\t<\/div>\n\t\t<ul class=\"featured-clinical-evidence-list text_colors\" role=\"list\">\n\t\t\t\t\t\t<li class=\"featured-clinical-evidence-item\" role=\"listitem\" aria-labelledby=\"post-title-8037\" aria-describedby=\"post-category-8037 post-excerpt-8037\">\n\t\t\t\t\t<div class=\"featured-clinical-evidence-item--text-container\" id=\"post-title-8037\">\n\t\t\t\t\t\t<a href=\"https:\/\/shockwavemedical.com\/en-eu\/clinical-evidence\/cad-iv\/\" class=\"featured-clinical-evidence-item--title\">\n\t\t\t\t\t\t\tDISRUPT CAD IV\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"featured-clinical-evidence-item--arrow\" aria-hidden=\"true\"><svg width=\"25\" height=\"27\" viewBox=\"0 0 25 27\" fill=\"none\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M3.5 26H21a2.5 2.5 0 002.5-2.5V7.875L16.625 1H6a2.5 2.5 0 00-2.5 2.5v3.75\" stroke=\"#5B6770\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\"\/><path d=\"M16 1v7.5h7.5M4.75 19.75a3.75 3.75 0 100-7.498 3.75 3.75 0 000 7.498v0zm5 1.25l-1.875-1.875\" stroke=\"#5B6770\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\"\/><\/svg><\/div>\n\t\t\t\t\t\t<div class=\"featured-clinical-evidence-item--arrow-hover\" aria-hidden=\"true\"><svg width=\"25\" height=\"27\" viewBox=\"0 0 25 27\" fill=\"none\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M3.5 26H21a2.5 2.5 0 002.5-2.5V7.875L16.625 1H6a2.5 2.5 0 00-2.5 2.5v3.75\" stroke=\"#00D2FF\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\"\/><path d=\"M16 1v7.5h7.5M4.75 19.75a3.75 3.75 0 100-7.498 3.75 3.75 0 000 7.498v0zm5 1.25l-1.875-1.875\" stroke=\"#00D2FF\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\"\/><\/svg><\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t<div class=\"featured-clinical-evidence-item--excerpt\" id=\"post-excerpt-8037\">\n\t\t\t\t\t\tShockwave coronary study demonstrating the safety and effectiveness of Shockwave IVL within a Japanese patient population. \t\t\t\t\t<\/div>\n\t\t\t\t\t<div class=\"featured-clinical-evidence-item--category\" id=\"post-category-8037\">\n\t\t\t\t\t\tCoronary IVL\t\t\t\t\t<\/div>\n\t\t\t\t<\/li>\n\t\t\t\t\t\t<li class=\"featured-clinical-evidence-item\" role=\"listitem\" aria-labelledby=\"post-title-8003\" aria-describedby=\"post-category-8003 post-excerpt-8003\">\n\t\t\t\t\t<div class=\"featured-clinical-evidence-item--text-container\" id=\"post-title-8003\">\n\t\t\t\t\t\t<a href=\"https:\/\/shockwavemedical.com\/en-eu\/clinical-evidence\/cad-iii\/\" class=\"featured-clinical-evidence-item--title\">\n\t\t\t\t\t\t\tDISRUPT CAD III\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"featured-clinical-evidence-item--arrow\" aria-hidden=\"true\"><svg width=\"25\" height=\"27\" viewBox=\"0 0 25 27\" fill=\"none\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M3.5 26H21a2.5 2.5 0 002.5-2.5V7.875L16.625 1H6a2.5 2.5 0 00-2.5 2.5v3.75\" stroke=\"#5B6770\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\"\/><path d=\"M16 1v7.5h7.5M4.75 19.75a3.75 3.75 0 100-7.498 3.75 3.75 0 000 7.498v0zm5 1.25l-1.875-1.875\" stroke=\"#5B6770\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\"\/><\/svg><\/div>\n\t\t\t\t\t\t<div class=\"featured-clinical-evidence-item--arrow-hover\" aria-hidden=\"true\"><svg width=\"25\" height=\"27\" viewBox=\"0 0 25 27\" fill=\"none\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M3.5 26H21a2.5 2.5 0 002.5-2.5V7.875L16.625 1H6a2.5 2.5 0 00-2.5 2.5v3.75\" stroke=\"#00D2FF\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\"\/><path d=\"M16 1v7.5h7.5M4.75 19.75a3.75 3.75 0 100-7.498 3.75 3.75 0 000 7.498v0zm5 1.25l-1.875-1.875\" stroke=\"#00D2FF\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\"\/><\/svg><\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t<div class=\"featured-clinical-evidence-item--excerpt\" id=\"post-excerpt-8003\">\n\t\t\t\t\t\tLargest and most rigorous Shockwave study showcasing the safety, effectiveness and ease of use of Shockwave coronary IVL\u202f.\t\t\t\t\t<\/div>\n\t\t\t\t\t<div class=\"featured-clinical-evidence-item--category\" id=\"post-category-8003\">\n\t\t\t\t\t\tCoronary IVL\t\t\t\t\t<\/div>\n\t\t\t\t<\/li>\n\t\t\t\t\t\t<li class=\"featured-clinical-evidence-item\" role=\"listitem\" aria-labelledby=\"post-title-7999\" aria-describedby=\"post-category-7999 post-excerpt-7999\">\n\t\t\t\t\t<div class=\"featured-clinical-evidence-item--text-container\" id=\"post-title-7999\">\n\t\t\t\t\t\t<a href=\"https:\/\/shockwavemedical.com\/en-eu\/clinical-evidence\/cad-ii\/\" class=\"featured-clinical-evidence-item--title\">\n\t\t\t\t\t\t\tDISRUPT CAD II\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"featured-clinical-evidence-item--arrow\" aria-hidden=\"true\"><svg width=\"25\" height=\"27\" viewBox=\"0 0 25 27\" fill=\"none\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M3.5 26H21a2.5 2.5 0 002.5-2.5V7.875L16.625 1H6a2.5 2.5 0 00-2.5 2.5v3.75\" stroke=\"#5B6770\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\"\/><path d=\"M16 1v7.5h7.5M4.75 19.75a3.75 3.75 0 100-7.498 3.75 3.75 0 000 7.498v0zm5 1.25l-1.875-1.875\" stroke=\"#5B6770\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\"\/><\/svg><\/div>\n\t\t\t\t\t\t<div class=\"featured-clinical-evidence-item--arrow-hover\" aria-hidden=\"true\"><svg width=\"25\" height=\"27\" viewBox=\"0 0 25 27\" fill=\"none\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M3.5 26H21a2.5 2.5 0 002.5-2.5V7.875L16.625 1H6a2.5 2.5 0 00-2.5 2.5v3.75\" stroke=\"#00D2FF\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\"\/><path d=\"M16 1v7.5h7.5M4.75 19.75a3.75 3.75 0 100-7.498 3.75 3.75 0 000 7.498v0zm5 1.25l-1.875-1.875\" stroke=\"#00D2FF\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\"\/><\/svg><\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t<div class=\"featured-clinical-evidence-item--excerpt\" id=\"post-excerpt-7999\">\n\t\t\t\t\t\tEuropean post-market study confirming DISRUPT CAD I results and showing strong safety and procedural success with Shockwave coronary IVL. \t\t\t\t\t<\/div>\n\t\t\t\t\t<div class=\"featured-clinical-evidence-item--category\" id=\"post-category-7999\">\n\t\t\t\t\t\tCoronary IVL\t\t\t\t\t<\/div>\n\t\t\t\t<\/li>\n\t\t\t<\/ul>\n<\/section>\n\n\n<section id=\"block_7ee0527ad3671e49838baf19ea953d6d\" class=\"block block--related-posts \" aria-labelledby=\"related-posts-title\">\n\t<div class=\"related-posts--title container\">\n\t\t<h2 id=\"related-posts-title\" class=\"text_colors\">Featured 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Sudhakar\t\t\t\t\t\t<\/a>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t<div class=\"related-posts-item--category\" id=\"post-category-10885\">\n\t\t\t\t\t\t<div class=\"tags\"><strong>Best Practices<\/strong> <\/div>\t\t\t\t\t<\/div>\n\t\t\t\t<\/li>\n\t\t\t\t\t\t<li class=\"related-posts-item card_slide\" role=\"listitem\">\n\t\t\t\t\t<figure class=\"related-posts-item--image\">\n\t\t\t\t\t\t<img decoding=\"async\" width=\"386\" height=\"540\" data-src=\"https:\/\/shockwavemedical.com\/wp-content\/uploads\/2025\/06\/BALI-Index-Image.png\" class=\"attachment-full size-full wp-post-image lazyload\" alt=\"BALI Makes Big Waves Demonstrating IVL Benefit in First Randomized Trial Showing Superiority Over Conventional Balloon-based Strategy\" data-srcset=\"https:\/\/shockwavemedical.com\/wp-content\/uploads\/2025\/06\/BALI-Index-Image.png 386w, https:\/\/shockwavemedical.com\/wp-content\/uploads\/2025\/06\/BALI-Index-Image-214x300.png 214w\" data-sizes=\"(max-width: 386px) 100vw, 386px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 386px; --smush-placeholder-aspect-ratio: 386\/540;\" \/>\t\t\t\t\t\t<div class=\"thumbnail-arrow\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t<i class=\"fa-regular fa-arrow-right\"><\/i>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/figure>\n\n\t\t\t\t\t<div class=\"related-posts-item--text-container\" id=\"post-title-12266\">\n\t\t\t\t\t\t<a href=\"https:\/\/shockwavemedical.com\/en-eu\/education\/bali-makes-big-waves-demonstrating-ivl-benefit-in-first-randomized-trial\/\" class=\"related-posts-item--title\" aria-labelledby=\"post-title-12266\" aria-describedby=\"post-category-12266\">\n\t\t\t\t\t\t\tBALI Makes Big Waves Demonstrating IVL Benefit in First Randomized Trial Showing Superiority Over Conventional Balloon-based Strategy\t\t\t\t\t\t<\/a>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t<div class=\"related-posts-item--category\" id=\"post-category-12266\">\n\t\t\t\t\t\t<div class=\"tags\"><strong>Clinical Evidence<\/strong> <\/div>\t\t\t\t\t<\/div>\n\t\t\t\t<\/li>\n\t\t\t\t\t\t<li class=\"related-posts-item card_slide\" role=\"listitem\">\n\t\t\t\t\t<figure class=\"related-posts-item--image\">\n\t\t\t\t\t\t<img decoding=\"async\" width=\"386\" height=\"539\" data-src=\"https:\/\/shockwavemedical.com\/wp-content\/uploads\/2020\/04\/coronary-ivl.png\" class=\"attachment-full size-full wp-post-image lazyload\" alt=\"Shockwave EMPOWER CAD First Case Review with Dr. Nieves Gonzalo\u00a0\" data-srcset=\"https:\/\/shockwavemedical.com\/wp-content\/uploads\/2020\/04\/coronary-ivl.png 386w, https:\/\/shockwavemedical.com\/wp-content\/uploads\/2020\/04\/coronary-ivl-215x300.png 215w\" data-sizes=\"(max-width: 386px) 100vw, 386px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 386px; --smush-placeholder-aspect-ratio: 386\/539;\" \/>\t\t\t\t\t\t<div class=\"thumbnail-arrow\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t<i class=\"fa-regular fa-arrow-right\"><\/i>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/figure>\n\n\t\t\t\t\t<div class=\"related-posts-item--text-container\" id=\"post-title-5760\">\n\t\t\t\t\t\t<a href=\"https:\/\/shockwavemedical.com\/en-eu\/education\/shockwave-empower-cad-first-case-review-with-dr-nieves-gonzalo\/\" class=\"related-posts-item--title\" aria-labelledby=\"post-title-5760\" aria-describedby=\"post-category-5760\">\n\t\t\t\t\t\t\tShockwave EMPOWER CAD First Case Review with Dr. Nieves Gonzalo\u00a0\t\t\t\t\t\t<\/a>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t<div class=\"related-posts-item--category\" id=\"post-category-5760\">\n\t\t\t\t\t\t<div class=\"tags\"><strong>Case Reviews<\/strong> <\/div>\t\t\t\t\t<\/div>\n\t\t\t\t<\/li>\n\t\t\t<\/ul>\n<\/section>\n\n\n<section id=\"block_e13bd31aa0ec86c59fe1d35515fa8f93\" class=\"block block--wysiwyg wysiwyg_styles u-bgColorNone shockwave container\">\n\t<div class=\"u-wysiwyg u-animation\">\n\t\t<hr \/>\n<p><span class=\"legal_copy\">*Procedural angiographic outcomes post stent. Independent angiographic core lab assessment.<\/span><\/p>\n<p><span class=\"legal_copy\">Kereiakes et al. Intravascular Lithotripsy for Treatment of Calcified Coronary Lesions: Patient-Level Pooled Analysis of the Disrupt CAD Studies. JACC Cardiovasc Interv. 2021 Jun 28;14(12):1337-1348.<\/span><\/p>\n\t<\/div>\n\t<\/section>\n\n<section\n\tid=\"block_905b5b07dab65457e910b027ea3a5c03\"\n\tclass=\"block block--spacer-with-optional-divider \"\n\taria-label=\"Spacer section with optional divider\">\n\t<div class=\"spacer-with-optional-divider-container container\">\n\n\t\t<!-- Space Above -->\n\t\t<div\n\t\t\tclass=\"space-above\"\n\t\t\tstyle=\"--aboveDesktop: 30px; --aboveMobile: 20px;\"\n\t\t\taria-hidden=\"true\"\n\t\t\trole=\"presentation\">\n\t\t<\/div>\n\n\t\t<!-- Optional Divider -->\n\t\t\n\t\t<!-- Space Below -->\n\t\t<div\n\t\t\tclass=\"space-below\"\n\t\t\tstyle=\"--belowDesktop: 0px; --belowMobile: 0px;\"\n\t\t\taria-hidden=\"true\"\n\t\t\trole=\"presentation\">\n\t\t<\/div>\n\n\t<\/div>\n<\/section>","protected":false},"excerpt":{"rendered":"<p>The\u202flargest systematic assessment of Shockwave coronary Intravascular Lithotripsy (IVL) to date based on individual patient data from DISRUPT CAD I\u2013IV.<\/p>\n","protected":false},"featured_media":4029,"template":"","format":[],"meta":{"_acf_changed":true,"content-type":""},"disease-state":[159],"product-tag":[255,251],"specialty":[295,328,332,336,344],"technology":[316],"class_list":["post-8041","clinical-evidence","type-clinical-evidence","status-publish","has-post-thumbnail","hentry","disease-state-coronary-artery-disease-en-uk","product-tag-shockwave-c2-en-uk-2","product-tag-shockwave-c2-en-uk","specialty-fellows-residents-en-uk","specialty-interventional-cardiologists-en-uk","specialty-interventional-radiologists-en-uk","specialty-nurses-technologists-en-uk","specialty-vascular-surgeons-en-uk","technology-coronary-ivl-en-uk"],"acf":[],"_links":{"self":[{"href":"https:\/\/shockwavemedical.com\/en-eu\/wp-json\/wp\/v2\/clinical-evidence\/8041","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/shockwavemedical.com\/en-eu\/wp-json\/wp\/v2\/clinical-evidence"}],"about":[{"href":"https:\/\/shockwavemedical.com\/en-eu\/wp-json\/wp\/v2\/types\/clinical-evidence"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/shockwavemedical.com\/en-eu\/wp-json\/wp\/v2\/media\/4029"}],"wp:attachment":[{"href":"https:\/\/shockwavemedical.com\/en-eu\/wp-json\/wp\/v2\/media?parent=8041"}],"wp:term":[{"taxonomy":"disease-state","embeddable":true,"href":"https:\/\/shockwavemedical.com\/en-eu\/wp-json\/wp\/v2\/disease-state?post=8041"},{"taxonomy":"format","embeddable":true,"href":"https:\/\/shockwavemedical.com\/en-eu\/wp-json\/wp\/v2\/format?post=8041"},{"taxonomy":"product-tag","embeddable":true,"href":"https:\/\/shockwavemedical.com\/en-eu\/wp-json\/wp\/v2\/product-tag?post=8041"},{"taxonomy":"specialty","embeddable":true,"href":"https:\/\/shockwavemedical.com\/en-eu\/wp-json\/wp\/v2\/specialty?post=8041"},{"taxonomy":"technology","embeddable":true,"href":"https:\/\/shockwavemedical.com\/en-eu\/wp-json\/wp\/v2\/technology?post=8041"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}