{"id":4679,"date":"2024-11-06T10:51:18","date_gmt":"2024-11-06T16:51:18","guid":{"rendered":"https:\/\/shockwavemedical.com\/?page_id=4679"},"modified":"2026-04-16T13:05:32","modified_gmt":"2026-04-16T18:05:32","slug":"coronary-sinus-reduction","status":"publish","type":"page","link":"https:\/\/shockwavemedical.com\/en-eu\/disease-states\/coronary-sinus-reduction\/","title":{"rendered":"Coronary Sinus Reduction for Refractory Angina\u00a0\u00a0"},"content":{"rendered":"\n\n\n<section id=\"block_cd5fcc70f863087e67beea09aea63f18\" class=\"block block--primary-header u-darkMode u-bgColor_primary\"\n\tstyle=\"--desktop-bg-image: url('https:\/\/shockwavemedical.com\/wp-content\/uploads\/2023\/04\/Reducer-Background-2.png');\n\t\t\t\t --mobile-bg-image: url('');\">\n\n\t<div class=\"primary-header-container text_colors\">\n\n\t\t<!-- Heading -->\n\t\t<div class=\"heading\">\n\t\t\t<h1 class=\"main-heading\">Coronary Sinus Reduction for Refractory Angina <\/h1>\n\t\t\t<h3 class=\"sub-heading\">Reducing pain. Restoring hope. Millions of patients with coronary artery disease (CAD) suffer from refractory angina despite receiving optimal medical therapy. Shockwave Reducer is designed to improve the symptoms of refractory angina through a permanent, controlled narrowing of the coronary sinus.* <\/h3>\n\t\t<\/div>\n\n\t\t<!-- Optional links -->\n\t\t\t\t\t<div class=\"links\">\n\t\t\t\t\n<a data-atom=\"button\" class=\"btn--line optional-button on-dark\" href=\"https:\/\/shockwavemedical.com\/en-eu\/reducer-overview-moa\/\" target=\"_self\" aria-label=\"Shockwave Reducer Overview and MOA - link to page\" >Shockwave Reducer Overview and MOA<i aria-hidden=\"true\" class=\"fa-sharp fa-arrow-right fa-solid\"><\/i><\/a>\n<a data-atom=\"button\" class=\"btn--line optional-button on-dark\" href=\"https:\/\/shockwavemedical.com\/en-eu\/products\/reducer\/\" target=\"_self\" aria-label=\"Shockwave Reducer - link to page\" >Shockwave Reducer<i aria-hidden=\"true\" class=\"fa-sharp fa-arrow-right fa-solid\"><\/i><\/a>\t\t\t<\/div>\n\t\t\n\t\t<!-- links - J&J -->\n\t\t\n\t\t<!-- Social share -->\n\t\t\t\t<!-- Foreground for Desktop -->\n\t\t\t\t\t<div class=\"desktop-foreground-file\">\n\t\t\t\t\t\t\t\t\t<img decoding=\"async\" data-src=\"https:\/\/shockwavemedical.com\/wp-content\/uploads\/2023\/04\/Shockwave_Reducer_Hero_Flipped.png\" alt=\"Digital rendering of reducer device\" role=\"img\" aria-label=\"Foreground image for desktop\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" class=\"lazyload\" style=\"--smush-placeholder-width: 955px; --smush-placeholder-aspect-ratio: 955\/970;\">\n\t\t\t\t\t\t\t<\/div>\n\t\t\n\t\t<!-- Foreground for Mobile -->\n\t\t\t\t\t<div class=\"mobile-foreground-file\">\n\t\t\t\t\t\t\t\t\t<img decoding=\"async\" data-src=\"https:\/\/shockwavemedical.com\/wp-content\/uploads\/2023\/04\/Shockwave_Reducer_Hero_Flipped.png\" alt=\"Digital rendering of reducer device\" role=\"img\" aria-label=\"Foreground image for mobile\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" class=\"lazyload\" style=\"--smush-placeholder-width: 955px; --smush-placeholder-aspect-ratio: 955\/970;\">\n\t\t\t\t\t\t\t<\/div>\n\t\t\t<\/div>\n<\/section>\n\n<section\n\tid=\"block_c05ceca6b5c73415a05fa48f294a0bba\"\n\tclass=\"block block--spacer-with-optional-divider \"\n\taria-label=\"Spacer section with optional divider\">\n\t<div class=\"spacer-with-optional-divider-container container\">\n\n\t\t<!-- Space Above -->\n\t\t<div\n\t\t\tclass=\"space-above\"\n\t\t\tstyle=\"--aboveDesktop: 30px; --aboveMobile: 20px;\"\n\t\t\taria-hidden=\"true\"\n\t\t\trole=\"presentation\">\n\t\t<\/div>\n\n\t\t<!-- Optional Divider -->\n\t\t\n\t\t<!-- Space Below -->\n\t\t<div\n\t\t\tclass=\"space-below\"\n\t\t\tstyle=\"--belowDesktop: 0px; --belowMobile: 0px;\"\n\t\t\taria-hidden=\"true\"\n\t\t\trole=\"presentation\">\n\t\t<\/div>\n\n\t<\/div>\n<\/section>\n\n\n<section id=\"block_421796314921402579ea1ceca0131850\" class=\"block block--wysiwyg wysiwyg_styles u-bgColorNone shockwave container\">\n\t<div class=\"u-wysiwyg u-animation\">\n\t\t<h2><img decoding=\"async\" class=\"alignnone wp-image-10497 size-medium lazyload\" style=\"--smush-placeholder-width: 300px; --smush-placeholder-aspect-ratio: 300\/79;padding: 0;\" data-src=\"https:\/\/shockwavemedical.com\/wp-content\/uploads\/2024\/11\/Shockwave-Reducer-Logo-300x79.png\" alt=\"\" width=\"300\" height=\"79\" data-srcset=\"https:\/\/shockwavemedical.com\/wp-content\/uploads\/2024\/11\/Shockwave-Reducer-Logo-300x79.png 300w, https:\/\/shockwavemedical.com\/wp-content\/uploads\/2024\/11\/Shockwave-Reducer-Logo-1024x270.png 1024w, https:\/\/shockwavemedical.com\/wp-content\/uploads\/2024\/11\/Shockwave-Reducer-Logo-768x202.png 768w, https:\/\/shockwavemedical.com\/wp-content\/uploads\/2024\/11\/Shockwave-Reducer-Logo-1536x405.png 1536w, https:\/\/shockwavemedical.com\/wp-content\/uploads\/2024\/11\/Shockwave-Reducer-Logo.png 2000w\" data-sizes=\"(max-width: 300px) 100vw, 300px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" \/><\/h2>\n<h2>Creating Better Outcomes: Percutaneous Treatment Option for Refractory Angina<\/h2>\n<p><span data-contrast=\"auto\">Usually a symptom of myocardial ischemia (a lack of blood flow to the heart muscle), angina may feel like pressure or squeezing in the chest and\/or pain in the shoulders, arms, neck, jaw or back. Many patients experiencing angina suffer symptoms that are severe, long-lasting and uncontrollable by traditional medical therapies. This severely debilitating condition is known as refractory angina.<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"4\" data-list-defn-props=\"{\"335552541\":1,\"335559685\":720,\"335559991\":360,\"469769226\":\"Symbol\",\"469769242\":[8226],\"469777803\":\"left\",\"469777804\":\"\uf0b7\",\"469777815\":\"hybridMultilevel\"}\" aria-setsize=\"-1\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"auto\">Angina pain is often a symptom of CAD, when plaque buildup occurs in the arteries supplying the oxygen-rich blood to the heart, forcing the heart to work harder.<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"4\" data-list-defn-props=\"{\"335552541\":1,\"335559685\":720,\"335559991\":360,\"469769226\":\"Symbol\",\"469769242\":[8226],\"469777803\":\"left\",\"469777804\":\"\uf0b7\",\"469777815\":\"hybridMultilevel\"}\" aria-setsize=\"-1\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"auto\">Many patients can get relief from their angina through revascularization from a coronary intervention or surgery. However, 25\u201340% continue to suffer from angina even after successful revascularization.<\/span><sup><span data-contrast=\"auto\">1, 2<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/sup><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"4\" data-list-defn-props=\"{\"335552541\":1,\"335559685\":720,\"335559991\":360,\"469769226\":\"Symbol\",\"469769242\":[8226],\"469777803\":\"left\",\"469777804\":\"\uf0b7\",\"469777815\":\"hybridMultilevel\"}\" aria-setsize=\"-1\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"auto\">Angina with nonobstructive coronary arteries (ANOCA) is increasingly recognized and may affect nearly one-third of patients undergoing invasive coronary angiography for suspected CAD.<\/span><sup><span data-contrast=\"auto\">3, 4<\/span><\/sup><span data-contrast=\"auto\">\u202f These patients do not have plaque buildup as a cause for their angina, and currently have limited options.<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/li>\n<\/ul>\n\t<\/div>\n\t<\/section>\n\n<section\n\tid=\"block_30a20d7dd1596eeb3e5d2d1da644d538\"\n\tclass=\"block block--spacer-with-optional-divider \"\n\taria-label=\"Spacer section with optional divider\">\n\t<div class=\"spacer-with-optional-divider-container container\">\n\n\t\t<!-- Space Above -->\n\t\t<div\n\t\t\tclass=\"space-above\"\n\t\t\tstyle=\"--aboveDesktop: 60px; --aboveMobile: 30px;\"\n\t\t\taria-hidden=\"true\"\n\t\t\trole=\"presentation\">\n\t\t<\/div>\n\n\t\t<!-- Optional Divider -->\n\t\t\n\t\t<!-- Space Below -->\n\t\t<div\n\t\t\tclass=\"space-below\"\n\t\t\tstyle=\"--belowDesktop: 0px; --belowMobile: 0px;\"\n\t\t\taria-hidden=\"true\"\n\t\t\trole=\"presentation\">\n\t\t<\/div>\n\n\t<\/div>\n<\/section>\n\n\n<section id=\"block_6ff99afb5dd8d6f9064c9b8123fd21e3\" class=\"block block--youtube-video-with-text-overlay text_colors \">\n\t<div class=\"block__container\">\n\t\t<div class=\"thumbnail\">\n\t\t\t\t\t\t\t<img decoding=\"async\" data-src=\"https:\/\/shockwavemedical.com\/wp-content\/uploads\/2025\/07\/Shockwave-Reducer_Story-of-Flow_thumbnail.jpg\" alt=\"Shockwave Reducer: A Story of Flow\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" class=\"lazyload\" style=\"--smush-placeholder-width: 1280px; --smush-placeholder-aspect-ratio: 1280\/720;\" \/>\n\t\t\t\t\t\t<div class=\"play-button-container\">\n\t\t\t\t<button type=\"button\" aria-label=\"Play video\" class=\"play-button btn\">\n\t\t\t\t\t<i class=\"fa-sharp fa-solid fa-play\" aria-hidden=\"true\"><\/i>\n\t\t\t\t<\/button>\n\t\t\t<\/div>\n\t\t<\/div>\n\n\t\t<!-- Heading, description, and button -->\n\t\t<div class=\"heading-description-button\">\n\t\t\t\t\t\t\t<h2 class=\"heading\">\n\t\t\t\t\tShockwave Reducer: A Story of Flow\t\t\t\t<\/h2>\n\t\t\t\n\t\t\t\t\t\t\t<p class=\"description\">\n\t\t\t\t\tIn this brief animated video, we explore coronary circulation, including how blood flow is maintained in a healthy heart versus how obstructive coronary artery disease affects blood flow, and how Shockwave Reducer\u2019s hypothesized mechanism of action (MOA) helps increase resistance to venous drainage to create back pressure that helps restore flow to the subendocardium. Created in partnership with OPTIMA.\t\t\t\t<\/p>\n\t\t\t\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div class=\"video-modal\" role=\"dialog\" aria-modal=\"true\" aria-labelledby=\"modal-title-block_6ff99afb5dd8d6f9064c9b8123fd21e3\" style=\"display: none;\">\n\t\t\t\t<button type=\"button\" aria-label=\"Close modal\" class=\"modal-close btn\">\n\t\t\t\t\t<i class=\"fa-sharp fa-regular fa-xmark\" aria-hidden=\"true\"><\/i>\n\t\t\t\t<\/button>\n\t\t\t\t<div class=\"modal-content\">\n\t\t\t\t\t<h2 id=\"modal-title-block_6ff99afb5dd8d6f9064c9b8123fd21e3\" class=\"sr-only\">Video Player<\/h2>\n\t\t\t\t\t<lite-youtube videoid=\"l4rlJf22BDw\" style=\"width: 100%; height: 100%;\" title=\"Shockwave Reducer: A Story of Flow\"><\/lite-youtube>\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t<\/div>\n<\/section>\n\n<section\n\tid=\"study-results\"\n\tclass=\"block block--spacer-with-optional-divider \"\n\taria-label=\"Spacer section with optional divider\">\n\t<div class=\"spacer-with-optional-divider-container container\">\n\n\t\t<!-- Space Above -->\n\t\t<div\n\t\t\tclass=\"space-above\"\n\t\t\tstyle=\"--aboveDesktop: 60px; --aboveMobile: 30px;\"\n\t\t\taria-hidden=\"true\"\n\t\t\trole=\"presentation\">\n\t\t<\/div>\n\n\t\t<!-- Optional Divider -->\n\t\t\n\t\t<!-- Space Below -->\n\t\t<div\n\t\t\tclass=\"space-below\"\n\t\t\tstyle=\"--belowDesktop: 0px; --belowMobile: 0px;\"\n\t\t\taria-hidden=\"true\"\n\t\t\trole=\"presentation\">\n\t\t<\/div>\n\n\t<\/div>\n<\/section>\n\n\n<section id=\"study-results\" class=\"block block--wysiwyg wysiwyg_styles u-bgColorNone shockwave container\">\n\t<div class=\"u-wysiwyg u-animation\">\n\t\t<h2><span class=\"TextRun SCXW114690562 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW114690562 BCX0\">Mounting Clinical Evidence: Study Results<\/span><\/span><span class=\"EOP SCXW114690562 BCX0\" data-ccp-props=\"{}\">\u00a0<\/span><\/h2>\n\t<\/div>\n\t<\/section>\n\n\n<section id=\"block_4ff015bc078538eeb355e820d3c5d676\" class=\"block block--accordion text_colors shockwave\">\n\n\t\t<div class=\"accordion__wrapper container\">\n\t\t\n\t\t\t\t\t\t<div class=\"accordion__top u-animation\">\n\t\t\t\t<h2 id=\"accordion-title-block_4ff015bc078538eeb355e820d3c5d676\" class=\"sr-only\">Accordion Section<\/h2>\n\t\t\t\t\n\t\t\t\t\t<div class=\"accordion\" data-layout=\"default_item\">\n\t\t\t\t\t\t<h3 class=\"accordion__trigger toggle__wrapper\">\n\t\t\t\t\t\t<button class=\" btn\" aria-expanded=\"false\" aria-controls=\"accordion-item-block_4ff015bc078538eeb355e820d3c5d676-0\">\n\t\t\t\t\t\t\tREDUCER-I Prospective, Multi-Center, Post-Market Study \t\t\t\t\t\t\t<div class=\"accordion-toggle\">\n\t\t\t\t\t\t\t\t<i class=\"fa-sharp fa-regular fa-chevron-down shockwave\" aria-hidden=\"true\"><\/i>\n\t\t\t\t\t\t\t\t<i class=\"fa-sharp fa-regular fa-plus jj\" aria-hidden=\"true\"><\/i>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/button>\n\t\t\t\t\t<\/h3>\n\t\t\t\t\t\t<div id=\"accordion-item-block_4ff015bc078538eeb355e820d3c5d676-0\" class=\"accordion__content\">\n\t\t\t\t\t\t\t<div class=\"grid grid--column grid-md--row-reverse\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"grid__col u-wysiwyg wysiwyg_styles\">\n\n\t\t\t\t\t\t\t\t\t<p><span data-contrast=\"auto\">REDUCER-I 12-month results demonstrated the safety and efficacy of the Reducer in improving angina severity and quality of life in patients suffering from refractory angina.<\/span><sup><span data-contrast=\"auto\">5<\/span><\/sup><span data-contrast=\"auto\"> Additionally, the outcomes showed a reduction in emergency department visits after Reducer implantation as well as clinically significant increase in the 6 Minute Walk Test distance. The results of the 400 patients enrolled at 25 centres and followed up to three years further augmented the findings from the initial COSIRA trial.<\/span><sup><span data-contrast=\"auto\">6 <\/span><\/sup><span data-ccp-props=\"{\"335559685\":0}\">\u00a0<\/span><\/p>\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"9\" data-list-defn-props=\"{\"335552541\":1,\"335559685\":720,\"335559991\":360,\"469769226\":\"Symbol\",\"469769242\":[8226],\"469777803\":\"left\",\"469777804\":\"\uf0b7\",\"469777815\":\"hybridMultilevel\"}\" aria-setsize=\"-1\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"auto\">71% of patients improved one or more CCS angina classes at 12 months<sup>\u2020 <\/sup><\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"9\" data-list-defn-props=\"{\"335552541\":1,\"335559685\":720,\"335559991\":360,\"469769226\":\"Symbol\",\"469769242\":[8226],\"469777803\":\"left\",\"469777804\":\"\uf0b7\",\"469777815\":\"hybridMultilevel\"}\" aria-setsize=\"-1\" data-aria-posinset=\"2\" data-aria-level=\"1\"><span data-contrast=\"auto\">26% of patients improved two or more CSS angina classes at 12 months<sup>\u2020<\/sup><\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><a href=\"https:\/\/shockwavemedical.com\/wp-content\/uploads\/2024\/11\/Reducer-I-Observational-Study-12-month-Results.pdf\" target=\"_blank\" rel=\"noopener\"><span data-contrast=\"auto\">Download 12-month results<\/span><\/a><\/p>\n<p>\u00a0<\/p>\n<p>REDUCER-I sub-analysis of patients with non-obstructive CAD* receiving a Reducer device showed a statistically significant improvement in Quality of Life (QoL) and an improvement in CCS class at 12 months.<\/p>\n<p><em>Non-obstructive CAD defined as less than 70% stenosis by visual estimate in all major epicardial coronary arteries.<\/em><\/p>\n<ul>\n<li>Both obstructive CAD (p<0.0001) and non-obstructive CAD (p<0.0002) cohorts had significant improvements in Mean SAQ Summary Score at 12 months<\/li>\n<li>Both obstructive CAD and non-obstructive CAD cohorts had improved CCS class at 12 months with no significant differences (p=0.1178) between the groups<\/li>\n<\/ul>\n<p><a href=\"https:\/\/shockwavemedical.com\/wp-content\/uploads\/2025\/07\/REDUCER-I-Non-Obstructive-Disease-Data.pdf\" target=\"_blank\" rel=\"noopener\"><span data-contrast=\"auto\">Download sub-analysis data<\/span><\/a><\/p>\n<p>\u00a0<\/p>\n<p>REDUCER I sub-analysis of patients with Diabetes Mellitus (DM) showed similar improvement in angina reduction (change in Canadian Cardiovascular Society Class (CCS)), similar Quality of Life (QoL) improvements and no difference in MACE-free survival at 12 months than the patients without history of DM.<\/p>\n<ul>\n<li>Patients with DM (71% improvement by \u22651 CCS class) and without DM (68% improvement by \u22651 CCS class) showed similar improvement in CCS class (p=0.66)<\/li>\n<li>Patients with and without DM showed similar QoL improvements in the mean Seattle Angina Questionnaire (SAQ) summary score at 12 months (p=0.27)<\/li>\n<\/ul>\n<p><a href=\"https:\/\/shockwavemedical.com\/wp-content\/uploads\/2025\/11\/Reducer-Diabetes-Mellitus-Brochure.pdf\">Download DM sub-analysis data<\/a><\/p>\n<h3><\/h3>\n<p>REDUCER I sub-analysis of female and male patients showed similar, significant improvement in angina reduction (change in Canadian Cardiovascular Society Class (CCS)), significant vs baseline and no difference in MACE-free survival at 12 months among both cohorts.<\/p>\n<ul>\n<li>Both female and male cohorts had improved CCS class at 12, 24 and 36 months with no significant differences between the groups, except at 6-months, favoring females (p=0.03).<\/li>\n<li>Both female and male cohorts had significant SAQ improvements compared to baseline (p\u22640.001).<\/li>\n<\/ul>\n<p><a href=\"https:\/\/shockwavemedical.com\/wp-content\/uploads\/2025\/11\/Reducer-Sex-Specific-Data-Brochure.pdf\">Download sex specific sub-analysis data<\/a><\/p>\n<p>\u00a0<\/p>\n<p><span class=\"legal_copy\"><sup><span data-contrast=\"auto\">\u2020<\/span><\/sup>Paired analysis for those with both baseline AND 12 month CSS class assessment.<br \/>\n*CAD = coronary artery disease<\/span><\/p>\n\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\n\t\t\t\t\t<div class=\"accordion\" data-layout=\"default_item\">\n\t\t\t\t\t\t<h3 class=\"accordion__trigger toggle__wrapper\">\n\t\t\t\t\t\t<button class=\" btn\" aria-expanded=\"false\" aria-controls=\"accordion-item-block_4ff015bc078538eeb355e820d3c5d676-1\">\n\t\t\t\t\t\t\tORBITA-COSMIC Randomized, Placebo-Controlled Study \t\t\t\t\t\t\t<div class=\"accordion-toggle\">\n\t\t\t\t\t\t\t\t<i class=\"fa-sharp fa-regular fa-chevron-down shockwave\" aria-hidden=\"true\"><\/i>\n\t\t\t\t\t\t\t\t<i class=\"fa-sharp fa-regular fa-plus jj\" aria-hidden=\"true\"><\/i>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/button>\n\t\t\t\t\t<\/h3>\n\t\t\t\t\t\t<div id=\"accordion-item-block_4ff015bc078538eeb355e820d3c5d676-1\" class=\"accordion__content\">\n\t\t\t\t\t\t\t<div class=\"grid grid--column grid-md--row-reverse\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"grid__col u-wysiwyg wysiwyg_styles\">\n\n\t\t\t\t\t\t\t\t\t<p><span data-contrast=\"auto\">Results of the independent ORBITA-COSMIC trial show Shockwave Reducer lessens angina frequency and improves heart disease related quality of life while improving subendocardial perfusion.<\/span><sup><span data-contrast=\"auto\">7 <\/span><\/sup><span data-contrast=\"auto\">51 patients were randomized<\/span><span data-contrast=\"auto\">\u00a0at six centres in the UK. Shockwave Reducer decreased the number of daily angina episodes compared to placebo at six months.<\/span><span data-ccp-props=\"{\"201341983\":0,\"335559740\":259}\">\u00a0<\/span><\/p>\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"6\" data-list-defn-props=\"{\"335552541\":1,\"335559685\":720,\"335559991\":360,\"469769226\":\"Symbol\",\"469769242\":[8226],\"469777803\":\"left\",\"469777804\":\"\uf0b7\",\"469777815\":\"hybridMultilevel\"}\" aria-setsize=\"-1\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"auto\">The results showed evidence of benefit on angina frequency reported using the smartphone ORBITA-app in the coronary sinus reducer (CSR) group compared to the placebo group<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"6\" data-list-defn-props=\"{\"335552541\":1,\"335559685\":720,\"335559991\":360,\"469769226\":\"Symbol\",\"469769242\":[8226],\"469777803\":\"left\",\"469777804\":\"\uf0b7\",\"469777815\":\"hybridMultilevel\"}\" aria-setsize=\"-1\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"auto\">Heart disease-related quality of life measured by MacNew Heart Disease Health-Related Quality of Life scores improved in the CSR group compared with the placebo group<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"6\" data-list-defn-props=\"{\"335552541\":1,\"335559685\":720,\"335559991\":360,\"469769226\":\"Symbol\",\"469769242\":[8226],\"469777803\":\"left\",\"469777804\":\"\uf0b7\",\"469777815\":\"hybridMultilevel\"}\" aria-setsize=\"-1\" data-aria-posinset=\"1\" data-aria-level=\"1\">While the primary imaging endpoint showed no improvement in transmural myocardial perfusion, it did show improvement in subendocardial perfusion, supporting the theorized mechanism of action of the Shockwave Reducer<\/li>\n<\/ul>\n<p><a href=\"https:\/\/shockwavemedical.com\/wp-content\/uploads\/2024\/11\/Shockwave-Reducer-ORBITA-COSMIC-Trial-Results-Brochure.pdf\" target=\"_blank\" rel=\"noopener\"><span data-contrast=\"auto\">Download results<\/span><\/a><\/p>\n\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\n\t\t\t\t\t<div class=\"accordion\" data-layout=\"default_item\">\n\t\t\t\t\t\t<h3 class=\"accordion__trigger toggle__wrapper\">\n\t\t\t\t\t\t<button class=\" btn\" aria-expanded=\"false\" aria-controls=\"accordion-item-block_4ff015bc078538eeb355e820d3c5d676-2\">\n\t\t\t\t\t\t\tCOSIRA Prospective, Randomized, Sham-Controlled Study \t\t\t\t\t\t\t<div class=\"accordion-toggle\">\n\t\t\t\t\t\t\t\t<i class=\"fa-sharp fa-regular fa-chevron-down shockwave\" aria-hidden=\"true\"><\/i>\n\t\t\t\t\t\t\t\t<i class=\"fa-sharp fa-regular fa-plus jj\" aria-hidden=\"true\"><\/i>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/button>\n\t\t\t\t\t<\/h3>\n\t\t\t\t\t\t<div id=\"accordion-item-block_4ff015bc078538eeb355e820d3c5d676-2\" class=\"accordion__content\">\n\t\t\t\t\t\t\t<div class=\"grid grid--column grid-md--row-reverse\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"grid__col u-wysiwyg wysiwyg_styles\">\n\n\t\t\t\t\t\t\t\t\t<p><span data-contrast=\"auto\">Beginning in 2010, the Reducer team and clinicians worldwide began studying the safety and effectiveness of the Shockwave Reducer device. 104 patients with Canadian Cardiovascular Society (CCS) class III or IV angina and myocardial ischemia who were not candidates for revascularization were enrolled. One randomized group received the device (treatment group) while another received a sham procedure (control group). COSIRA** demonstrated patients receiving the Shockwave Reducer device achieved a statistically significant improvement in angina symptoms and quality of life compared to patients in a sham control group.<sup>6<\/sup><\/span><\/p>\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"7\" data-list-defn-props=\"{\"335552541\":1,\"335559685\":720,\"335559991\":360,\"469769226\":\"Symbol\",\"469769242\":[8226],\"469777803\":\"left\",\"469777804\":\"\uf0b7\",\"469777815\":\"hybridMultilevel\"}\" aria-setsize=\"-1\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"auto\">71% of patients improved 1 or more CCS angina classes at 6 months<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"7\" data-list-defn-props=\"{\"335552541\":1,\"335559685\":720,\"335559991\":360,\"469769226\":\"Symbol\",\"469769242\":[8226],\"469777803\":\"left\",\"469777804\":\"\uf0b7\",\"469777815\":\"hybridMultilevel\"}\" aria-setsize=\"-1\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"auto\">35% of patients improved 2 or more CCS angina classes at 6 months<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"7\" data-list-defn-props=\"{\"335552541\":1,\"335559685\":720,\"335559991\":360,\"469769226\":\"Symbol\",\"469769242\":[8226],\"469777803\":\"left\",\"469777804\":\"\uf0b7\",\"469777815\":\"hybridMultilevel\"}\" aria-setsize=\"-1\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"auto\">Quality of life improved 17.6 points for patients who received the implant, vs. 7.6 points for patients in the control group<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><a href=\"https:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJMoa1402556\" target=\"_blank\" rel=\"noopener\"><span data-contrast=\"auto\">Download results<\/span><\/a><\/p>\n<p><span data-contrast=\"auto\">**COSIRA = COronary SInus Reducer for treatment of Refractory Angina <\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\n\t\t\t<\/div>\n\n\t\t\t<\/div>\n<\/section>\n\n<section\n\tid=\"block_30a20d7dd1596eeb3e5d2d1da644d538\"\n\tclass=\"block block--spacer-with-optional-divider \"\n\taria-label=\"Spacer section with optional divider\">\n\t<div class=\"spacer-with-optional-divider-container container\">\n\n\t\t<!-- Space Above -->\n\t\t<div\n\t\t\tclass=\"space-above\"\n\t\t\tstyle=\"--aboveDesktop: 60px; --aboveMobile: 30px;\"\n\t\t\taria-hidden=\"true\"\n\t\t\trole=\"presentation\">\n\t\t<\/div>\n\n\t\t<!-- Optional Divider -->\n\t\t\n\t\t<!-- Space Below -->\n\t\t<div\n\t\t\tclass=\"space-below\"\n\t\t\tstyle=\"--belowDesktop: 0px; --belowMobile: 0px;\"\n\t\t\taria-hidden=\"true\"\n\t\t\trole=\"presentation\">\n\t\t<\/div>\n\n\t<\/div>\n<\/section>\n\n\n<section id=\"block_3accf8291bd53a29f311591d7b3bd9b8\" class=\"block block--cta-button-bar text_colors \">\n\t<div class=\"cta-button-bar--container\">\n\t\t<h2 id=\"block_3accf8291bd53a29f311591d7b3bd9b8-heading\" class=\"heading\">\n\t\t\tCOSIRA II Clinical Trial: Now enrolling patients in the UK\t\t<\/h2>\n\t\t<div class=\"buttons\">\n\t\t\t\t\t\t\t<ul class=\"cta-button-bar--links-container\" role=\"list\" aria-label=\"Call-to-action buttons\">\n\t\t\t\t\t\t\t\t\t\t\t<li class=\"resource-list--link\" role=\"listitem\">\n\t\t\t\t\t\t\t\n<a data-atom=\"button\" class=\"on-blue btn--primary\" href=\"https:\/\/shockwavemedical.com\/en-eu\/clinical-evidence\/cosira-ii\/\" target=\"_self\" aria-label=\"Explore more - link to page\">Explore more<i aria-hidden=\"true\" class=\"fa-sharp fa-arrow-right fa-solid\"><\/i><\/a>\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t\t<\/ul>\n\t\t\t\t\t<\/div>\n\t<\/div>\n<\/section>\n\n<section\n\tid=\"block_30a20d7dd1596eeb3e5d2d1da644d538\"\n\tclass=\"block block--spacer-with-optional-divider \"\n\taria-label=\"Spacer section with optional divider\">\n\t<div class=\"spacer-with-optional-divider-container container\">\n\n\t\t<!-- Space Above -->\n\t\t<div\n\t\t\tclass=\"space-above\"\n\t\t\tstyle=\"--aboveDesktop: 60px; --aboveMobile: 30px;\"\n\t\t\taria-hidden=\"true\"\n\t\t\trole=\"presentation\">\n\t\t<\/div>\n\n\t\t<!-- Optional Divider -->\n\t\t\n\t\t<!-- Space Below -->\n\t\t<div\n\t\t\tclass=\"space-below\"\n\t\t\tstyle=\"--belowDesktop: 0px; --belowMobile: 0px;\"\n\t\t\taria-hidden=\"true\"\n\t\t\trole=\"presentation\">\n\t\t<\/div>\n\n\t<\/div>\n<\/section>\n\n\n<section id=\"block_767dc0f983a1a359ab5bd7e91a46e97a\" class=\"block block--wysiwyg wysiwyg_styles u-bgColorNone container\">\n\t<div class=\"u-wysiwyg u-animation\">\n\t\t<h2>Building on Clinical Data: COSIRA II Study<\/h2>\n<p><span data-contrast=\"auto\">Currently enrolling: COSIRA*<\/span><span data-contrast=\"auto\">*<\/span><span data-contrast=\"auto\">\u202fII is the next-phase clinical trial designed to gather further evidence of the safety and effectiveness of Shockwave Reducer. The study is a U.S.-based, multicenter, randomized, double-blind, sham-controlled trial. ClinicalTrials.gov Identifier: NCT05102019.\u00a0<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">**COSIRA = COronary SInus Reducer for treatment of Refractory Angina<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n\t<\/div>\n\t<\/section>\n\n\n<section id=\"block_13ebf59c31a3e0b5897d74c2f2f4a1e4\" class=\"block block--content-3-or-4-up text_colors \" aria-labelledby=\"section-heading-block_13ebf59c31a3e0b5897d74c2f2f4a1e4\">\n\t<div class=\"container\">\n\n\t\t<!-- Header -->\n\t\t\n\t\t<!-- Cards Section -->\n\t\t<ul class=\"cards three-cards\" role=\"list\">\n\t\t\t\t\t\t\t<li class=\"card content-3-or-4-up-card three-cards\" role=\"listitem\">\n\t\t\t\t\t\t\t\t\t\t\t<div class=\"card-image\">\n\t\t\t\t\t\t\t<img decoding=\"async\" data-src=\"https:\/\/shockwavemedical.com\/wp-content\/uploads\/2024\/11\/Coronary-Sinus-Reducer-thumbnail.jpg\"\n\t\t\t\t\t\t\t\talt=\"youtube thumbnail screenshot of presenter speaking at TCT\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" class=\"lazyload\" style=\"--smush-placeholder-width: 1280px; --smush-placeholder-aspect-ratio: 1280\/720;\" \/>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\n\t\t\t\t\t<!-- Card Content -->\n\t\t\t\t\t<div class=\"card-heading-description-link\">\n\t\t\t\t\t\t<h3 class=\"card-heading\">COSIRA II Symposium: The Coronary Sinus Reducer <\/h3>\n\n\t\t\t\t\t\t<div class=\"card-description-link\">\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\n<a data-atom=\"button\" class=\"card-link btn--tertiary\" href=\"https:\/\/shockwavemedical.com\/en-eu\/education\/shockwave-cosira-ii-symposium-the-coronary-sinus-reducer\/\" target=\"_self\" aria-label=\"Read more about COSIRA II Symposium: The Coronary Sinus Reducer \">Watch Video<i aria-hidden=\"true\" class=\"fa-sharp fa-arrow-right fa-light\"><\/i><\/a>\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/li>\n\t\t\t\t\t\t\t<li class=\"card content-3-or-4-up-card three-cards\" role=\"listitem\">\n\t\t\t\t\t\t\t\t\t\t\t<div class=\"card-image\">\n\t\t\t\t\t\t\t<img decoding=\"async\" data-src=\"https:\/\/shockwavemedical.com\/wp-content\/uploads\/2024\/11\/reducer-angina-thumbnal.jpg\"\n\t\t\t\t\t\t\t\talt=\"youtube thumbnail screenshot of presenter speaking at TCT\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" class=\"lazyload\" style=\"--smush-placeholder-width: 1280px; --smush-placeholder-aspect-ratio: 1280\/720;\" \/>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\n\t\t\t\t\t<!-- Card Content -->\n\t\t\t\t\t<div class=\"card-heading-description-link\">\n\t\t\t\t\t\t<h3 class=\"card-heading\">COSIRA II Symposium: Angina: The Scope of the Challenge <\/h3>\n\n\t\t\t\t\t\t<div class=\"card-description-link\">\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\n<a data-atom=\"button\" class=\"card-link btn--tertiary\" href=\"https:\/\/shockwavemedical.com\/en-eu\/education\/cosira-ii-symposium-angina-the-scope-of-the-challenge\/\" target=\"_self\" aria-label=\"Read more about COSIRA II Symposium: Angina: The Scope of the Challenge \">Watch Video<i aria-hidden=\"true\" class=\"fa-sharp fa-arrow-right fa-light\"><\/i><\/a>\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/li>\n\t\t\t\t\t\t\t<li class=\"card content-3-or-4-up-card three-cards\" role=\"listitem\">\n\t\t\t\t\t\t\t\t\t\t\t<div class=\"card-image\">\n\t\t\t\t\t\t\t<img decoding=\"async\" data-src=\"https:\/\/shockwavemedical.com\/wp-content\/uploads\/2024\/11\/reducer-future.jpg\"\n\t\t\t\t\t\t\t\talt=\"youtube thumbnail screenshot of presenter speaking at TCT\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" class=\"lazyload\" style=\"--smush-placeholder-width: 1280px; --smush-placeholder-aspect-ratio: 1280\/720;\" \/>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\n\t\t\t\t\t<!-- Card Content -->\n\t\t\t\t\t<div class=\"card-heading-description-link\">\n\t\t\t\t\t\t<h3 class=\"card-heading\">COSIRA II Symposium: The Future of Clinical Data for the Reducer <\/h3>\n\n\t\t\t\t\t\t<div class=\"card-description-link\">\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\n<a data-atom=\"button\" class=\"card-link btn--tertiary\" href=\"https:\/\/shockwavemedical.com\/en-eu\/education\/cosira-ii-symposium-the-future-of-clinical-data-for-the-reducer\/\" target=\"_self\" aria-label=\"Read more about COSIRA II Symposium: The Future of Clinical Data for the Reducer \">Watch Video<i aria-hidden=\"true\" class=\"fa-sharp fa-arrow-right fa-light\"><\/i><\/a>\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/li>\n\t\t\t\t\t<\/ul>\n\t<\/div>\n<\/section>\n\n\n<section id=\"block_7889c86550e9ce996acd830c39606d7f\" class=\"block block--wysiwyg wysiwyg_styles u-bgColorNone container\">\n\t<div class=\"u-wysiwyg u-animation\">\n\t\t<p><span class=\"legal_copy\">The physicians featured are paid consultants for Shockwave Medical.<\/span><\/p>\n\t<\/div>\n\t<\/section>\n\n<section\n\tid=\"block_30a20d7dd1596eeb3e5d2d1da644d538\"\n\tclass=\"block block--spacer-with-optional-divider \"\n\taria-label=\"Spacer section with optional divider\">\n\t<div class=\"spacer-with-optional-divider-container container\">\n\n\t\t<!-- Space Above -->\n\t\t<div\n\t\t\tclass=\"space-above\"\n\t\t\tstyle=\"--aboveDesktop: 60px; --aboveMobile: 30px;\"\n\t\t\taria-hidden=\"true\"\n\t\t\trole=\"presentation\">\n\t\t<\/div>\n\n\t\t<!-- Optional Divider -->\n\t\t\n\t\t<!-- Space Below -->\n\t\t<div\n\t\t\tclass=\"space-below\"\n\t\t\tstyle=\"--belowDesktop: 0px; --belowMobile: 0px;\"\n\t\t\taria-hidden=\"true\"\n\t\t\trole=\"presentation\">\n\t\t<\/div>\n\n\t<\/div>\n<\/section>\n\n\n<section id=\"resources\" class=\"block block--resource-list text_colors \">\n\t<div class=\"block__container\">\n\t\t<div class=\"container-inner\">\n\t\t\t\t\t\t\t<h3 id=\"resources-heading\" class=\"heading\">\n\t\t\t\t\tResources\t\t\t\t<\/h3>\n\t\t\t\n\t\t\t\t\t\t\t<ul class=\"resource-list--links-container\" role=\"list\" aria-label=\"Resource links\" style=\"--column-count: 3;\">\n\t\t\t\t\t\t\t\t\t\t\t<li class=\"resource-list--link\" role=\"listitem\">\n\t\t\t\t\t\t\t\n<a data-atom=\"button\" class=\"btn--line\" href=\"https:\/\/shockwavemedical.com\/wp-content\/uploads\/2024\/11\/Shockwave-Reducer-Spec-Sheet.pdf\" target=\"_blank\" aria-label=\"Shockwave Reducer Product Spec Sheet - download asset\" download><span class=\"text-content\">Shockwave Reducer Product Spec Sheet<\/span><i aria-hidden=\"true\" class=\"fa-arrow-down-to-bracket fa-light\"><\/i><\/a>\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t\t\t\t<li class=\"resource-list--link\" role=\"listitem\">\n\t\t\t\t\t\t\t\n<a data-atom=\"button\" class=\"btn--line\" href=\"https:\/\/ifu.sw-reducer.com\/\" target=\"_blank\" aria-label=\"Shockwave Reducer Instructions for Use - opens in a new tab\" rel=\"noopener\"><span class=\"text-content\">Shockwave Reducer Instructions for Use<\/span><i aria-hidden=\"true\" class=\"fa-sharp fa-arrow-right fa-light\"><\/i><\/a>\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t\t\t\t<li class=\"resource-list--link\" role=\"listitem\">\n\t\t\t\t\t\t\t\n<a data-atom=\"button\" class=\"btn--line\" href=\"https:\/\/shockwavemedical.com\/wp-content\/uploads\/2024\/11\/Shockwave-Reducer-Physician-Brochure.pdf\" target=\"_blank\" aria-label=\"Shockwave Reducer Brochure - download asset\" download><span class=\"text-content\">Shockwave Reducer Brochure<\/span><i aria-hidden=\"true\" class=\"fa-arrow-down-to-bracket fa-light\"><\/i><\/a>\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t\t<\/ul>\n\t\t\t\t\t<\/div>\n\t<\/div>\n<\/section>\n\n<section\n\tid=\"block_30a20d7dd1596eeb3e5d2d1da644d538\"\n\tclass=\"block block--spacer-with-optional-divider \"\n\taria-label=\"Spacer section with optional divider\">\n\t<div class=\"spacer-with-optional-divider-container container\">\n\n\t\t<!-- Space Above -->\n\t\t<div\n\t\t\tclass=\"space-above\"\n\t\t\tstyle=\"--aboveDesktop: 60px; --aboveMobile: 30px;\"\n\t\t\taria-hidden=\"true\"\n\t\t\trole=\"presentation\">\n\t\t<\/div>\n\n\t\t<!-- Optional Divider -->\n\t\t\n\t\t<!-- Space Below -->\n\t\t<div\n\t\t\tclass=\"space-below\"\n\t\t\tstyle=\"--belowDesktop: 0px; --belowMobile: 0px;\"\n\t\t\taria-hidden=\"true\"\n\t\t\trole=\"presentation\">\n\t\t<\/div>\n\n\t<\/div>\n<\/section>\n\n\n<section id=\"block_901d9902f479e2619dbb7a58a2b1c987\" class=\"block block--wysiwyg wysiwyg_styles u-bgColorNone container\">\n\t<div class=\"u-wysiwyg u-animation\">\n\t\t<hr \/>\n<p><span class=\"legal_copy\">*Shockwave Reducer is commercially available in select European countries and has been implanted in over 3,500 patients. It is currently under clinical investigation in the U.S. <\/span><\/p>\n<p><span class=\"legal_copy\"><strong>Caution:<\/strong> In the United States, Shockwave Reducer is an investigational device, limited by United States law to investigational use. The Reducer is subject of Investigational testing and is being studied in the COSIRA-II trial in Canada. <\/span><\/p>\n<p><span class=\"legal_copy\">Shockwave Reducer is commercially available in certain countries outside the U.S. and Canada. Please contact your local representative for specific country availability. Prior to use, please reference the Instructions for Use for more information on warnings, precautions and adverse events: <a href=\"https:\/\/ifu.sw-reducer.com\/\" target=\"_blank\" rel=\"noopener\">ifu.sw-reducer.com<\/a><\/span><\/p>\n<p><span class=\"legal_copy\">1: Abdallah, M. J Am Coll Cardiol 2017;69:2039-50.<br \/>\n2: Stone, G. 2-year results from the ABSORB IV randomized trial. TCT 2019.<br \/>\n3: Patel, M. N Engl J Med 2010; 362:886-895.<br \/>\n4: Samuels, B. J Am Coll Cardiol 2023; 82:1245-1263.<br \/>\n5: Verheye, S. Results from the REDUCER-I Study. ESC 2024.<br \/>\n6: Verheye S, Jolicoeur EM, Behan MW, et al. Efficacy of a device to narrow the coronary sinus in refractory angina. N Engl J Med 2015; 372: 519-527.<br \/>\n7: Foley et al. The Lancet. 2024 Apr 8; https:\/\/doi.org\/10.1016\/S0140-6736(24)00256-3.<\/span><\/p>\n\t<\/div>\n\t<\/section>\n\n<section\n\tid=\"block_30a20d7dd1596eeb3e5d2d1da644d538\"\n\tclass=\"block block--spacer-with-optional-divider \"\n\taria-label=\"Spacer section with optional divider\">\n\t<div class=\"spacer-with-optional-divider-container container\">\n\n\t\t<!-- Space Above -->\n\t\t<div\n\t\t\tclass=\"space-above\"\n\t\t\tstyle=\"--aboveDesktop: 60px; --aboveMobile: 30px;\"\n\t\t\taria-hidden=\"true\"\n\t\t\trole=\"presentation\">\n\t\t<\/div>\n\n\t\t<!-- Optional Divider -->\n\t\t\n\t\t<!-- Space Below -->\n\t\t<div\n\t\t\tclass=\"space-below\"\n\t\t\tstyle=\"--belowDesktop: 0px; --belowMobile: 0px;\"\n\t\t\taria-hidden=\"true\"\n\t\t\trole=\"presentation\">\n\t\t<\/div>\n\n\t<\/div>\n<\/section>","protected":false},"excerpt":{"rendered":"<p>Shockwave Reducer is designed to treat the symptoms of refractory angina through a permanent, controlled narrowing of the coronary sinus.<\/p>\n","protected":false},"author":15,"featured_media":4044,"parent":9780,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"content-type":"","footnotes":""},"class_list":["post-4679","page","type-page","status-publish","has-post-thumbnail","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/shockwavemedical.com\/en-eu\/wp-json\/wp\/v2\/pages\/4679","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/shockwavemedical.com\/en-eu\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/shockwavemedical.com\/en-eu\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/shockwavemedical.com\/en-eu\/wp-json\/wp\/v2\/users\/15"}],"replies":[{"embeddable":true,"href":"https:\/\/shockwavemedical.com\/en-eu\/wp-json\/wp\/v2\/comments?post=4679"}],"version-history":[{"count":1,"href":"https:\/\/shockwavemedical.com\/en-eu\/wp-json\/wp\/v2\/pages\/4679\/revisions"}],"predecessor-version":[{"id":13979,"href":"https:\/\/shockwavemedical.com\/en-eu\/wp-json\/wp\/v2\/pages\/4679\/revisions\/13979"}],"up":[{"embeddable":true,"href":"https:\/\/shockwavemedical.com\/en-eu\/wp-json\/wp\/v2\/pages\/9780"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/shockwavemedical.com\/en-eu\/wp-json\/wp\/v2\/media\/4044"}],"wp:attachment":[{"href":"https:\/\/shockwavemedical.com\/en-eu\/wp-json\/wp\/v2\/media?parent=4679"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}