{"id":4679,"date":"2024-11-06T10:51:18","date_gmt":"2024-11-06T16:51:18","guid":{"rendered":"https:\/\/shockwavemedical.com\/?page_id=4679"},"modified":"2026-08-27T12:35:20","modified_gmt":"2026-08-27T17:35:20","slug":"coronary-sinus-reduction","status":"publish","type":"page","link":"https:\/\/shockwavemedical.com\/en-eu\/disease-states\/coronary-sinus-reduction\/","title":{"rendered":"Coronary Sinus Reduction for Refractory Angina\u00a0\u00a0"},"content":{"rendered":"\n\n\n<section id=\"block_fffe67095f608230e5d68f7d3f2a98cc\" class=\"block block--primary-header u-darkMode u-bgColor_primary shockwave\"\n\tstyle=\"--desktop-bg-image: url('https:\/\/shockwavemedical.com\/wp-content\/uploads\/2023\/04\/Reducer-Background-2.png');\n\t\t\t\t --mobile-bg-image: url('');\">\n\n\t<div class=\"primary-header-container text_colors\">\n\n\t\t<!-- Heading -->\n\t\t<div class=\"heading\">\n\t\t\t<h1 class=\"main-heading\">Coronary Sinus Reduction for Refractory Angina <\/h1>\n\t\t\t<h3 class=\"sub-heading\">Redistribute flow. Relieve pain. Restore hope. Millions of patients with coronary artery disease (CAD) suffer from chronic angina despite receiving optimal medical therapy. Shockwave Reducer is designed to improve the symptoms of chronic angina through a permanent, controlled narrowing of the coronary sinus.* <\/h3>\n\t\t<\/div>\n\n\t\t<!-- Optional links -->\n\t\t\t\t\t<div class=\"links\">\n\t\t\t\t\n<a data-atom=\"button\" class=\"btn--line optional-button on-dark\" href=\"https:\/\/shockwavemedical.com\/en-eu\/reducer-overview-moa\/\" target=\"_self\" aria-label=\"Shockwave Reducer Overview and MOA - link to page\" >Shockwave Reducer Overview and MOA<i aria-hidden=\"true\" class=\"fa-sharp fa-arrow-right fa-solid\"><\/i><\/a>\n<a data-atom=\"button\" class=\"btn--line optional-button on-dark\" href=\"https:\/\/shockwavemedical.com\/en-eu\/products\/reducer\/\" target=\"_self\" aria-label=\"Shockwave Reducer - link to page\" >Shockwave Reducer<i aria-hidden=\"true\" class=\"fa-sharp fa-arrow-right fa-solid\"><\/i><\/a>\t\t\t<\/div>\n\t\t\n\t\t<!-- links - J&J -->\n\t\t\n\t\t<!-- Social share -->\n\t\t\t\t<!-- Foreground for Desktop -->\n\t\t\t\t\t<div class=\"desktop-foreground-file\">\n\t\t\t\t\t\t\t\t\t<img decoding=\"async\" data-src=\"https:\/\/shockwavemedical.com\/wp-content\/uploads\/2023\/04\/Shockwave_Reducer_Hero_Flipped.png\" alt=\"Digital rendering of reducer device\" role=\"img\" aria-label=\"Foreground image for desktop\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" class=\"lazyload\" style=\"--smush-placeholder-width: 955px; --smush-placeholder-aspect-ratio: 955\/970;\">\n\t\t\t\t\t\t\t<\/div>\n\t\t\n\t\t<!-- Foreground for Mobile -->\n\t\t\t\t\t<div class=\"mobile-foreground-file\">\n\t\t\t\t\t\t\t\t\t<img decoding=\"async\" data-src=\"https:\/\/shockwavemedical.com\/wp-content\/uploads\/2023\/04\/Shockwave_Reducer_Hero_Flipped.png\" alt=\"Digital rendering of reducer device\" role=\"img\" aria-label=\"Foreground image for mobile\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" class=\"lazyload\" style=\"--smush-placeholder-width: 955px; --smush-placeholder-aspect-ratio: 955\/970;\">\n\t\t\t\t\t\t\t<\/div>\n\t\t\t<\/div>\n<\/section>\n\n<section\n\tid=\"block_c05ceca6b5c73415a05fa48f294a0bba\"\n\tclass=\"block block--spacer-with-optional-divider \"\n\taria-label=\"Spacer section with optional divider\">\n\t<div class=\"spacer-with-optional-divider-container container\">\n\n\t\t<!-- Space Above -->\n\t\t<div\n\t\t\tclass=\"space-above\"\n\t\t\tstyle=\"--aboveDesktop: 30px; --aboveMobile: 20px;\"\n\t\t\taria-hidden=\"true\"\n\t\t\trole=\"presentation\">\n\t\t<\/div>\n\n\t\t<!-- Optional Divider -->\n\t\t\n\t\t<!-- Space Below -->\n\t\t<div\n\t\t\tclass=\"space-below\"\n\t\t\tstyle=\"--belowDesktop: 0px; --belowMobile: 0px;\"\n\t\t\taria-hidden=\"true\"\n\t\t\trole=\"presentation\">\n\t\t<\/div>\n\n\t<\/div>\n<\/section>\n\n\n<section id=\"block_bb22cfcb8ce739e893e62ecb2b65aa61\" class=\"block block--wysiwyg wysiwyg_styles u-bgColorNone shockwave container\">\n\t<div class=\"u-wysiwyg u-animation\">\n\t\t<h2><img decoding=\"async\" class=\"alignnone wp-image-10497 size-medium lazyload\" style=\"--smush-placeholder-width: 300px; --smush-placeholder-aspect-ratio: 300\/79;padding: 0;\" data-src=\"https:\/\/shockwavemedical.com\/wp-content\/uploads\/2024\/11\/Shockwave-Reducer-Logo-300x79.png\" alt=\"\" width=\"300\" height=\"79\" data-srcset=\"https:\/\/shockwavemedical.com\/wp-content\/uploads\/2024\/11\/Shockwave-Reducer-Logo-300x79.png 300w, https:\/\/shockwavemedical.com\/wp-content\/uploads\/2024\/11\/Shockwave-Reducer-Logo-1024x270.png 1024w, https:\/\/shockwavemedical.com\/wp-content\/uploads\/2024\/11\/Shockwave-Reducer-Logo-768x202.png 768w, https:\/\/shockwavemedical.com\/wp-content\/uploads\/2024\/11\/Shockwave-Reducer-Logo-1536x405.png 1536w, https:\/\/shockwavemedical.com\/wp-content\/uploads\/2024\/11\/Shockwave-Reducer-Logo.png 2000w\" data-sizes=\"(max-width: 300px) 100vw, 300px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" \/><\/h2>\n<h2>Creating Better Outcomes: Percutaneous Treatment Option for Chronic Angina<\/h2>\n<p><span data-contrast=\"auto\">Usually a symptom of myocardial ischemia (a lack of blood flow to the heart muscle), angina may feel like pressure or squeezing in the chest and\/or pain in the shoulders, arms, neck, jaw or back. Many patients experiencing angina suffer symptoms that are severe, long-lasting and uncontrollable by traditional medical therapies. This severely debilitating condition is known as refractory, or chronic, angina.\u00a0<\/span><\/p>\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"4\" data-list-defn-props=\"{\"335552541\":1,\"335559685\":720,\"335559991\":360,\"469769226\":\"Symbol\",\"469769242\":[8226],\"469777803\":\"left\",\"469777804\":\"\uf0b7\",\"469777815\":\"hybridMultilevel\"}\" aria-setsize=\"-1\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"auto\">Angina pain is often a symptom of CAD, when plaque buildup occurs in the arteries supplying the oxygen-rich blood to the heart, forcing the heart to work harder.<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"4\" data-list-defn-props=\"{\"335552541\":1,\"335559685\":720,\"335559991\":360,\"469769226\":\"Symbol\",\"469769242\":[8226],\"469777803\":\"left\",\"469777804\":\"\uf0b7\",\"469777815\":\"hybridMultilevel\"}\" aria-setsize=\"-1\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"auto\">Many patients can get relief from their angina through revascularization from a coronary intervention or surgery. However, 25\u201340% continue to suffer from angina even after successful revascularization.<\/span><sup><span data-contrast=\"auto\">1, 2<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/sup><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"4\" data-list-defn-props=\"{\"335552541\":1,\"335559685\":720,\"335559991\":360,\"469769226\":\"Symbol\",\"469769242\":[8226],\"469777803\":\"left\",\"469777804\":\"\uf0b7\",\"469777815\":\"hybridMultilevel\"}\" aria-setsize=\"-1\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"auto\">Angina with nonobstructive coronary arteries (ANOCA) is increasingly recognized and may affect nearly one-third of patients undergoing invasive coronary angiography for suspected CAD.<\/span><sup><span data-contrast=\"auto\">3, 4<\/span><\/sup><span data-contrast=\"auto\">\u202f These patients do not have plaque buildup as a cause for their angina, and currently have limited options.<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/li>\n<\/ul>\n\t<\/div>\n\t<\/section>\n\n<section\n\tid=\"block_30a20d7dd1596eeb3e5d2d1da644d538\"\n\tclass=\"block block--spacer-with-optional-divider \"\n\taria-label=\"Spacer section with optional divider\">\n\t<div class=\"spacer-with-optional-divider-container container\">\n\n\t\t<!-- Space Above -->\n\t\t<div\n\t\t\tclass=\"space-above\"\n\t\t\tstyle=\"--aboveDesktop: 60px; --aboveMobile: 30px;\"\n\t\t\taria-hidden=\"true\"\n\t\t\trole=\"presentation\">\n\t\t<\/div>\n\n\t\t<!-- Optional Divider -->\n\t\t\n\t\t<!-- Space Below -->\n\t\t<div\n\t\t\tclass=\"space-below\"\n\t\t\tstyle=\"--belowDesktop: 0px; --belowMobile: 0px;\"\n\t\t\taria-hidden=\"true\"\n\t\t\trole=\"presentation\">\n\t\t<\/div>\n\n\t<\/div>\n<\/section>\n\n\n<section id=\"block_6ff99afb5dd8d6f9064c9b8123fd21e3\" class=\"block block--youtube-video-with-text-overlay text_colors \">\n\t<div class=\"block__container\">\n\t\t<div class=\"thumbnail\">\n\t\t\t\t\t\t\t<img decoding=\"async\" data-src=\"https:\/\/shockwavemedical.com\/wp-content\/uploads\/2025\/07\/Shockwave-Reducer_Story-of-Flow_thumbnail.jpg\" alt=\"Shockwave Reducer: A Story of Flow\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" class=\"lazyload\" style=\"--smush-placeholder-width: 1280px; --smush-placeholder-aspect-ratio: 1280\/720;\" \/>\n\t\t\t\t\t\t<div class=\"play-button-container\">\n\t\t\t\t<button type=\"button\" aria-label=\"Play video\" class=\"play-button btn\">\n\t\t\t\t\t<i class=\"fa-sharp fa-solid fa-play\" aria-hidden=\"true\"><\/i>\n\t\t\t\t<\/button>\n\t\t\t<\/div>\n\t\t<\/div>\n\n\t\t<!-- Heading, description, and button -->\n\t\t<div class=\"heading-description-button\">\n\t\t\t\t\t\t\t<h2 class=\"heading\">\n\t\t\t\t\tShockwave Reducer: A Story of Flow\t\t\t\t<\/h2>\n\t\t\t\n\t\t\t\t\t\t\t<p class=\"description\">\n\t\t\t\t\tIn this brief animated video, we explore coronary circulation, including how blood flow is maintained in a healthy heart versus how obstructive coronary artery disease affects blood flow, and how Shockwave Reducer\u2019s hypothesized mechanism of action (MOA) helps increase resistance to venous drainage to create back pressure that helps restore flow to the subendocardium. Created in partnership with OPTIMA.\t\t\t\t<\/p>\n\t\t\t\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div class=\"video-modal\" role=\"dialog\" aria-modal=\"true\" aria-labelledby=\"modal-title-block_6ff99afb5dd8d6f9064c9b8123fd21e3\" style=\"display: none;\">\n\t\t\t\t<button type=\"button\" aria-label=\"Close modal\" class=\"modal-close btn\">\n\t\t\t\t\t<i class=\"fa-sharp fa-regular fa-xmark\" aria-hidden=\"true\"><\/i>\n\t\t\t\t<\/button>\n\t\t\t\t<div class=\"modal-content\">\n\t\t\t\t\t<h2 id=\"modal-title-block_6ff99afb5dd8d6f9064c9b8123fd21e3\" class=\"sr-only\">Video Player<\/h2>\n\t\t\t\t\t<lite-youtube videoid=\"l4rlJf22BDw\" style=\"width: 100%; height: 100%;\" title=\"Shockwave Reducer: A Story of Flow\"><\/lite-youtube>\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t<\/div>\n<\/section>\n\n<section\n\tid=\"study-results\"\n\tclass=\"block block--spacer-with-optional-divider \"\n\taria-label=\"Spacer section with optional divider\">\n\t<div class=\"spacer-with-optional-divider-container container\">\n\n\t\t<!-- Space Above -->\n\t\t<div\n\t\t\tclass=\"space-above\"\n\t\t\tstyle=\"--aboveDesktop: 60px; --aboveMobile: 30px;\"\n\t\t\taria-hidden=\"true\"\n\t\t\trole=\"presentation\">\n\t\t<\/div>\n\n\t\t<!-- Optional Divider -->\n\t\t\n\t\t<!-- Space Below -->\n\t\t<div\n\t\t\tclass=\"space-below\"\n\t\t\tstyle=\"--belowDesktop: 0px; --belowMobile: 0px;\"\n\t\t\taria-hidden=\"true\"\n\t\t\trole=\"presentation\">\n\t\t<\/div>\n\n\t<\/div>\n<\/section>\n\n\n<section id=\"study-results\" class=\"block block--wysiwyg wysiwyg_styles u-bgColorNone shockwave container\">\n\t<div class=\"u-wysiwyg u-animation\">\n\t\t<h2>Real-World Impact Backed By Clinical Data<\/h2>\n<p>Shockwave Reducer delivers effective angina relief for patients whose symptoms cannot be controlled through traditional therapies \u2013 and it\u2019s been proven by rigorous clinical data, including randomized sham-controlled trials. Learn how our clinically validated therapy is reducing pain and restoring hope for millions of patients.<\/p>\n\t<\/div>\n\t<\/section>\n\n\n<section id=\"block_57e42e95071e475cc5cf074f52313031\" class=\"block block--accordion text_colors shockwave\">\n\n\t\t<div class=\"accordion__wrapper container\">\n\t\t\n\t\t\t\t\t\t<div class=\"accordion__top u-animation\">\n\t\t\t\t<h2 id=\"accordion-title-block_57e42e95071e475cc5cf074f52313031\" class=\"sr-only\">Accordion Section<\/h2>\n\t\t\t\t\n\t\t\t\t\t<div class=\"accordion\" data-layout=\"default_item\">\n\t\t\t\t\t\t<h3 class=\"accordion__trigger toggle__wrapper\">\n\t\t\t\t\t\t<button class=\" btn\" aria-expanded=\"false\" aria-controls=\"accordion-item-block_57e42e95071e475cc5cf074f52313031-0\">\n\t\t\t\t\t\t\tREDUCER-I Prospective, Multi-Center, Post-Market Study(5)*\t\t\t\t\t\t\t<div class=\"accordion-toggle\">\n\t\t\t\t\t\t\t\t<i class=\"fa-sharp fa-regular fa-chevron-down shockwave\" aria-hidden=\"true\"><\/i>\n\t\t\t\t\t\t\t\t<i class=\"fa-sharp fa-regular fa-plus jj\" aria-hidden=\"true\"><\/i>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/button>\n\t\t\t\t\t<\/h3>\n\t\t\t\t\t\t<div id=\"accordion-item-block_57e42e95071e475cc5cf074f52313031-0\" class=\"accordion__content\">\n\t\t\t\t\t\t\t<div class=\"grid grid--column grid-md--row-reverse\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"grid__col u-wysiwyg wysiwyg_styles\">\n\n\t\t\t\t\t\t\t\t\t<p><span data-contrast=\"auto\"><strong>REDUCER-I 12-month results<\/strong> demonstrated the safety and efficacy of the Reducer in improving angina severity and quality of life in patients suffering from chronic angina.<\/span><span data-contrast=\"auto\"> Additionally, the outcomes showed a reduction in emergency department visits after Reducer implantation as well as clinically significant increase in the 6 Minute Walk Test distance.\u00a0<\/span><\/p>\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"9\" data-list-defn-props=\"{\"335552541\":1,\"335559685\":720,\"335559991\":360,\"469769226\":\"Symbol\",\"469769242\":[8226],\"469777803\":\"left\",\"469777804\":\"\uf0b7\",\"469777815\":\"hybridMultilevel\"}\" aria-setsize=\"-1\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"auto\">Canadian Cardiovascular Society Class (CCS) was significantly better compared to baseline (p<0.001).<sup>\u2020 <\/sup><\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"9\" data-list-defn-props=\"{\"335552541\":1,\"335559685\":720,\"335559991\":360,\"469769226\":\"Symbol\",\"469769242\":[8226],\"469777803\":\"left\",\"469777804\":\"\uf0b7\",\"469777815\":\"hybridMultilevel\"}\" aria-setsize=\"-1\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"auto\">71% of patients improved one or more CCS angina classes at 12 months.<sup>\u2020 <\/sup><\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"9\" data-list-defn-props=\"{\"335552541\":1,\"335559685\":720,\"335559991\":360,\"469769226\":\"Symbol\",\"469769242\":[8226],\"469777803\":\"left\",\"469777804\":\"\uf0b7\",\"469777815\":\"hybridMultilevel\"}\" aria-setsize=\"-1\" data-aria-posinset=\"2\" data-aria-level=\"1\"><span data-contrast=\"auto\">26% of patients improved two or more CCS angina classes at 12 months.<sup>\u2020<\/sup><\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/li>\n<\/ul>\n<p>The treatment effect was durable; interim analysis showed improvements in CCS class and Quality of Life (QoL) were sustained through 3 years.<sup>6<\/sup><\/p>\n<p><a href=\"https:\/\/shockwavemedical.com\/wp-content\/uploads\/2024\/11\/Reducer-I-Observational-Study-12-month-Results.pdf\" target=\"_blank\" rel=\"noopener\"><span data-contrast=\"auto\">Download 12-month results<\/span><\/a><\/p>\n<p>\u00a0<\/p>\n<p><strong>REDUCER-I sub-analysis of patients with non-obstructive CAD<\/strong>** receiving a Reducer device showed a statistically significant improvement in QoL and an improvement in CCS class at 12 months.<sup>7<\/sup><\/p>\n<p><em>Non-obstructive CAD defined as less than 70% stenosis by visual estimate in all major epicardial coronary arteries.<\/em><\/p>\n<ul>\n<li>Both obstructive and non-obstructive CAD cohorts had significant improvements in Mean Seattle Angina Questionnaire (SAQ) Summary Score at 12 months:\n<ul>\n<li>Obstructive CAD: Mean SAQ Summary Score 52.9 \u00b1 17.2 at baseline\/69.1 \u00b1 17.2 at 12 months (p<0.0001).<\/li>\n<li>Non-obstructive CAD: Mean SAQ Summary Score 51.0 \u00b1 17.8 at baseline\/60.8 \u00b1 19.9 at 12 months (p<0.0002).<\/li>\n<\/ul>\n<\/li>\n<li>Both obstructive and non-obstructive CAD cohorts had improved CCS class at 12 months with no significant differences between the groups:\n<ul>\n<li>\u22651 CCS class improvement (p=0.11): Obstructive CAD 71.7% (162\/226), non-obstructive CAD 60.3% (35\/58).<\/li>\n<li>\u22652 CCS class improvement (p=0.17): Obstructive CAD 26.7% (59\/226), non-obstructive CAD 17.2% (10\/58).<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p><a href=\"https:\/\/shockwavemedical.com\/wp-content\/uploads\/2025\/07\/REDUCER-I-Non-Obstructive-Disease-Data.pdf\" target=\"_blank\" rel=\"noopener\"><span data-contrast=\"auto\">Download sub-analysis data<\/span><\/a><\/p>\n<p>\u00a0<\/p>\n<p><strong>REDUCER I sub-analysis of patients with Diabetes Mellitus (DM)<\/strong> showed similar improvement in angina reduction (change in CCS), similar QoL improvements and no difference in MACE-free survival at 12 months than the patients without history of DM.<sup>8<\/sup><\/p>\n<ul>\n<li>Patients with and without DM showed similar CCS class improvement (DM 71%, without DM 68% \u2013 for \u22651 CCS class ; p=0.66).<\/li>\n<li>Patients with and without DM showed similar QoL improvements in the mean SAQ summary score at 12 months (DM 17.4, without DM 19.9; p=0.27).<\/li>\n<\/ul>\n<p><a href=\"https:\/\/shockwavemedical.com\/wp-content\/uploads\/2025\/11\/Reducer-Diabetes-Mellitus-Brochure.pdf\">Download DM sub-analysis data<\/a><\/p>\n<h3><\/h3>\n<p><strong>REDUCER I sub-analysis of female and male patients<\/strong> showed similar, significant improvement in angina reduction (change in CCS), significant vs baseline and no difference in MACE-free survival at 12 months among both cohorts.<sup>9<\/sup><\/p>\n<ul>\n<li>Both female and male cohorts had improved CCS class at 12, 24, and 36 months with no significant differences between the groups (female 86%, male 75% at 36 months), except at 6 months, favoring females (p=0.03).<\/li>\n<li>Both female and male cohorts had significant SAQ summary score improvement at 12 months (female improved by 22.6\u00b120.7 vs male 17.6 \u00b119.4; p<0.001).<\/li>\n<\/ul>\n<p><a href=\"https:\/\/shockwavemedical.com\/wp-content\/uploads\/2025\/11\/Reducer-Sex-Specific-Data-Brochure.pdf\">Download sex specific sub-analysis data<\/a><\/p>\n<p>\u00a0<\/p>\n<p><span class=\"legal_copy\">*REDUCER I is a Shockwave Medical-sponsored trial.<br \/>\n**CAD = coronary artery disease<br \/>\n<sup>\u2020<\/sup>Paired analysis for those with both baseline AND 12 month CSS class assessment.<\/span><\/p>\n\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\n\t\t\t\t\t<div class=\"accordion\" data-layout=\"default_item\">\n\t\t\t\t\t\t<h3 class=\"accordion__trigger toggle__wrapper\">\n\t\t\t\t\t\t<button class=\" btn\" aria-expanded=\"false\" aria-controls=\"accordion-item-block_57e42e95071e475cc5cf074f52313031-1\">\n\t\t\t\t\t\t\tORBITA-COSMIC Randomized, Placebo-Controlled Study(10)\t\t\t\t\t\t\t<div class=\"accordion-toggle\">\n\t\t\t\t\t\t\t\t<i class=\"fa-sharp fa-regular fa-chevron-down shockwave\" aria-hidden=\"true\"><\/i>\n\t\t\t\t\t\t\t\t<i class=\"fa-sharp fa-regular fa-plus jj\" aria-hidden=\"true\"><\/i>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/button>\n\t\t\t\t\t<\/h3>\n\t\t\t\t\t\t<div id=\"accordion-item-block_57e42e95071e475cc5cf074f52313031-1\" class=\"accordion__content\">\n\t\t\t\t\t\t\t<div class=\"grid grid--column grid-md--row-reverse\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"grid__col u-wysiwyg wysiwyg_styles\">\n\n\t\t\t\t\t\t\t\t\t<p><span data-contrast=\"auto\">Results of the independent ORBITA-COSMIC trial show Shockwave Reducer lessens angina frequency and improves heart disease related quality of life while improving subendocardial perfusion.<\/span><sup><span data-contrast=\"auto\">\u00a0<\/span><\/sup><span data-contrast=\"auto\">51 patients were randomized<\/span><span data-contrast=\"auto\">\u00a0at six centres in the UK. Shockwave Reducer decreased the number of daily angina episodes compared to placebo at six months.<\/span><span data-ccp-props=\"{\"201341983\":0,\"335559740\":259}\">\u00a0<\/span><\/p>\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"6\" data-list-defn-props=\"{\"335552541\":1,\"335559685\":720,\"335559991\":360,\"469769226\":\"Symbol\",\"469769242\":[8226],\"469777803\":\"left\",\"469777804\":\"\uf0b7\",\"469777815\":\"hybridMultilevel\"}\" aria-setsize=\"-1\" data-aria-posinset=\"1\" data-aria-level=\"1\">The results showed evidence of benefit on SAQ angina frequency reported using the smartphone ORBITA-app in the coronary sinus reducer (CSR) group compared to the placebo group [16.0 (95% CrI 5.1 to 27.3) Pr(Benefit)=99.7%].<\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"6\" data-list-defn-props=\"{\"335552541\":1,\"335559685\":720,\"335559991\":360,\"469769226\":\"Symbol\",\"469769242\":[8226],\"469777803\":\"left\",\"469777804\":\"\uf0b7\",\"469777815\":\"hybridMultilevel\"}\" aria-setsize=\"-1\" data-aria-posinset=\"1\" data-aria-level=\"1\">MacNew Heart Disease Health-Related Quality of Life scores improved in the CSR group compared with the placebo group [Placebo-controlled increment 0.60 (95% CrI 0.15 to 1.06) Pr(Benefit)=99.4%].<\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"6\" data-list-defn-props=\"{\"335552541\":1,\"335559685\":720,\"335559991\":360,\"469769226\":\"Symbol\",\"469769242\":[8226],\"469777803\":\"left\",\"469777804\":\"\uf0b7\",\"469777815\":\"hybridMultilevel\"}\" aria-setsize=\"-1\" data-aria-posinset=\"1\" data-aria-level=\"1\">While the primary imaging endpoint showed no improvement in transmural myocardial perfusion (difference 0.06 mL\/min\/g; 95% CrI \u22120.09 to 0.20; Pr[benefit]=78.8%), ORBITA\u2011COSMIC demonstrated a significant improvement in subendocardial perfusion, reflected by an increase in the endocardial\u2011to\u2011epicardial stress myocardial blood flow ratio (+0.09 in ischaemic segments; 95% CrI 0.00 to 0.17; probability of benefit 98.2%), supporting the theorized mechanism of action of the Shockwave Reducer.<\/li>\n<\/ul>\n<p><a href=\"https:\/\/shockwavemedical.com\/wp-content\/uploads\/2024\/11\/Shockwave-Reducer-ORBITA-COSMIC-Trial-Results-Brochure.pdf\" target=\"_blank\" rel=\"noopener\"><span data-contrast=\"auto\">Download results<\/span><\/a><\/p>\n\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\n\t\t\t\t\t<div class=\"accordion\" data-layout=\"default_item\">\n\t\t\t\t\t\t<h3 class=\"accordion__trigger toggle__wrapper\">\n\t\t\t\t\t\t<button class=\" btn\" aria-expanded=\"false\" aria-controls=\"accordion-item-block_57e42e95071e475cc5cf074f52313031-2\">\n\t\t\t\t\t\t\tCOSIRA Prospective, Randomized, Sham-Controlled Study(11)*\t\t\t\t\t\t\t<div class=\"accordion-toggle\">\n\t\t\t\t\t\t\t\t<i class=\"fa-sharp fa-regular fa-chevron-down shockwave\" aria-hidden=\"true\"><\/i>\n\t\t\t\t\t\t\t\t<i class=\"fa-sharp fa-regular fa-plus jj\" aria-hidden=\"true\"><\/i>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/button>\n\t\t\t\t\t<\/h3>\n\t\t\t\t\t\t<div id=\"accordion-item-block_57e42e95071e475cc5cf074f52313031-2\" class=\"accordion__content\">\n\t\t\t\t\t\t\t<div class=\"grid grid--column grid-md--row-reverse\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"grid__col u-wysiwyg wysiwyg_styles\">\n\n\t\t\t\t\t\t\t\t\t<p><span data-contrast=\"auto\">Beginning in 2010, the Reducer team and clinicians worldwide began studying the safety and effectiveness of the Shockwave Reducer device. 104 patients with Canadian Cardiovascular Society (CCS) class III or IV angina and myocardial ischemia who were not candidates for revascularization were enrolled. One randomized group received the device (treatment group) while another received a sham procedure (control group). COSIRA** demonstrated patients receiving the Shockwave Reducer device achieved a statistically significant improvement in angina symptoms and quality of life compared to patients in a sham control group.<\/span><\/p>\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"7\" data-list-defn-props=\"{\"335552541\":1,\"335559685\":720,\"335559991\":360,\"469769226\":\"Symbol\",\"469769242\":[8226],\"469777803\":\"left\",\"469777804\":\"\uf0b7\",\"469777815\":\"hybridMultilevel\"}\" aria-setsize=\"-1\" data-aria-posinset=\"1\" data-aria-level=\"1\">71% of Reducer treatment group had \u22651 CCS angina classes improvement at 6 months compared to 42% in the control group (p=0.003).<\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"7\" data-list-defn-props=\"{\"335552541\":1,\"335559685\":720,\"335559991\":360,\"469769226\":\"Symbol\",\"469769242\":[8226],\"469777803\":\"left\",\"469777804\":\"\uf0b7\",\"469777815\":\"hybridMultilevel\"}\" aria-setsize=\"-1\" data-aria-posinset=\"1\" data-aria-level=\"1\">35% of Reducer treatment group had \u22652 CCS angina classes improvement at 6 months compared to 15% in the control group (p=0.02).<\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"7\" data-list-defn-props=\"{\"335552541\":1,\"335559685\":720,\"335559991\":360,\"469769226\":\"Symbol\",\"469769242\":[8226],\"469777803\":\"left\",\"469777804\":\"\uf0b7\",\"469777815\":\"hybridMultilevel\"}\" aria-setsize=\"-1\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"auto\">Quality of life improved 17.6 points for patients who received the implant, vs. 7.6 points for patients in the control group<\/span><span data-ccp-props=\"{}\"> (p=0.048).<\/span><\/li>\n<\/ul>\n<p><a href=\"https:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJMoa1402556\" target=\"_blank\" rel=\"noopener\"><span data-contrast=\"auto\">Download results<\/span><\/a><\/p>\n<p><span data-contrast=\"auto\">*COSIRA is a Shockwave Medical-sponsored trial.<br \/>\n**COSIRA = COronary SInus Reducer for treatment of Refractory Angina<\/span><\/p>\n\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\n\t\t\t<\/div>\n\n\t\t\t<\/div>\n<\/section>\n\n<section\n\tid=\"block_30a20d7dd1596eeb3e5d2d1da644d538\"\n\tclass=\"block block--spacer-with-optional-divider \"\n\taria-label=\"Spacer section with optional divider\">\n\t<div class=\"spacer-with-optional-divider-container container\">\n\n\t\t<!-- Space Above -->\n\t\t<div\n\t\t\tclass=\"space-above\"\n\t\t\tstyle=\"--aboveDesktop: 60px; --aboveMobile: 30px;\"\n\t\t\taria-hidden=\"true\"\n\t\t\trole=\"presentation\">\n\t\t<\/div>\n\n\t\t<!-- Optional Divider -->\n\t\t\n\t\t<!-- Space Below -->\n\t\t<div\n\t\t\tclass=\"space-below\"\n\t\t\tstyle=\"--belowDesktop: 0px; --belowMobile: 0px;\"\n\t\t\taria-hidden=\"true\"\n\t\t\trole=\"presentation\">\n\t\t<\/div>\n\n\t<\/div>\n<\/section>\n\n\n<section id=\"block_3accf8291bd53a29f311591d7b3bd9b8\" class=\"block block--cta-button-bar text_colors \">\n\t<div class=\"cta-button-bar--container\">\n\t\t<h2 id=\"block_3accf8291bd53a29f311591d7b3bd9b8-heading\" class=\"heading\">\n\t\t\tCOSIRA II Clinical Trial: Now enrolling patients in the UK\t\t<\/h2>\n\t\t<div class=\"buttons\">\n\t\t\t\t\t\t\t<ul class=\"cta-button-bar--links-container\" role=\"list\" aria-label=\"Call-to-action buttons\">\n\t\t\t\t\t\t\t\t\t\t\t<li class=\"resource-list--link\" role=\"listitem\">\n\t\t\t\t\t\t\t\n<a data-atom=\"button\" class=\"on-blue btn--primary\" href=\"https:\/\/shockwavemedical.com\/en-eu\/clinical-evidence\/cosira-ii\/\" target=\"_self\" aria-label=\"Explore more - link to page\">Explore more<i aria-hidden=\"true\" class=\"fa-sharp fa-arrow-right fa-solid\"><\/i><\/a>\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t\t<\/ul>\n\t\t\t\t\t<\/div>\n\t<\/div>\n<\/section>\n\n<section\n\tid=\"block_30a20d7dd1596eeb3e5d2d1da644d538\"\n\tclass=\"block block--spacer-with-optional-divider \"\n\taria-label=\"Spacer section with optional divider\">\n\t<div class=\"spacer-with-optional-divider-container container\">\n\n\t\t<!-- Space Above -->\n\t\t<div\n\t\t\tclass=\"space-above\"\n\t\t\tstyle=\"--aboveDesktop: 60px; --aboveMobile: 30px;\"\n\t\t\taria-hidden=\"true\"\n\t\t\trole=\"presentation\">\n\t\t<\/div>\n\n\t\t<!-- Optional Divider -->\n\t\t\n\t\t<!-- Space Below -->\n\t\t<div\n\t\t\tclass=\"space-below\"\n\t\t\tstyle=\"--belowDesktop: 0px; --belowMobile: 0px;\"\n\t\t\taria-hidden=\"true\"\n\t\t\trole=\"presentation\">\n\t\t<\/div>\n\n\t<\/div>\n<\/section>\n\n\n<section id=\"block_767dc0f983a1a359ab5bd7e91a46e97a\" class=\"block block--wysiwyg wysiwyg_styles u-bgColorNone container\">\n\t<div class=\"u-wysiwyg u-animation\">\n\t\t<h2>Building on Clinical Data: COSIRA II Study<\/h2>\n<p><span data-contrast=\"auto\">Currently enrolling: COSIRA*<\/span><span data-contrast=\"auto\">*<\/span><span data-contrast=\"auto\">\u202fII is the next-phase clinical trial designed to gather further evidence of the safety and effectiveness of Shockwave Reducer. The study is a U.S.-based, multicenter, randomized, double-blind, sham-controlled trial. ClinicalTrials.gov Identifier: NCT05102019.\u00a0<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">**COSIRA = COronary SInus Reducer for treatment of Refractory Angina<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n\t<\/div>\n\t<\/section>\n\n\n<section id=\"block_13ebf59c31a3e0b5897d74c2f2f4a1e4\" class=\"block block--content-3-or-4-up text_colors \" aria-labelledby=\"section-heading-block_13ebf59c31a3e0b5897d74c2f2f4a1e4\">\n\t<div class=\"container\">\n\n\t\t<!-- Header -->\n\t\t\n\t\t<!-- Cards Section -->\n\t\t<ul class=\"cards three-cards\" role=\"list\">\n\t\t\t\t\t\t\t<li class=\"card content-3-or-4-up-card three-cards\" role=\"listitem\">\n\t\t\t\t\t\t\t\t\t\t\t<div class=\"card-image\">\n\t\t\t\t\t\t\t<img decoding=\"async\" data-src=\"https:\/\/shockwavemedical.com\/wp-content\/uploads\/2024\/11\/Coronary-Sinus-Reducer-thumbnail.jpg\"\n\t\t\t\t\t\t\t\talt=\"youtube thumbnail screenshot of presenter speaking at TCT\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" class=\"lazyload\" style=\"--smush-placeholder-width: 1280px; --smush-placeholder-aspect-ratio: 1280\/720;\" \/>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\n\t\t\t\t\t<!-- Card Content -->\n\t\t\t\t\t<div class=\"card-heading-description-link\">\n\t\t\t\t\t\t<h3 class=\"card-heading\">COSIRA II Symposium: The Coronary Sinus Reducer <\/h3>\n\n\t\t\t\t\t\t<div class=\"card-description-link\">\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\n<a data-atom=\"button\" class=\"card-link btn--tertiary\" href=\"https:\/\/shockwavemedical.com\/en-eu\/education\/shockwave-cosira-ii-symposium-the-coronary-sinus-reducer\/\" target=\"_self\" aria-label=\"Read more about COSIRA II Symposium: The Coronary Sinus Reducer \">Watch Video<i aria-hidden=\"true\" class=\"fa-sharp fa-arrow-right fa-light\"><\/i><\/a>\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/li>\n\t\t\t\t\t\t\t<li class=\"card content-3-or-4-up-card three-cards\" role=\"listitem\">\n\t\t\t\t\t\t\t\t\t\t\t<div class=\"card-image\">\n\t\t\t\t\t\t\t<img decoding=\"async\" data-src=\"https:\/\/shockwavemedical.com\/wp-content\/uploads\/2024\/11\/reducer-angina-thumbnal.jpg\"\n\t\t\t\t\t\t\t\talt=\"youtube thumbnail screenshot of presenter speaking at TCT\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" class=\"lazyload\" style=\"--smush-placeholder-width: 1280px; --smush-placeholder-aspect-ratio: 1280\/720;\" \/>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\n\t\t\t\t\t<!-- Card Content -->\n\t\t\t\t\t<div class=\"card-heading-description-link\">\n\t\t\t\t\t\t<h3 class=\"card-heading\">COSIRA II Symposium: Angina: The Scope of the Challenge <\/h3>\n\n\t\t\t\t\t\t<div class=\"card-description-link\">\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\n<a data-atom=\"button\" class=\"card-link btn--tertiary\" href=\"https:\/\/shockwavemedical.com\/en-eu\/education\/cosira-ii-symposium-angina-the-scope-of-the-challenge\/\" target=\"_self\" aria-label=\"Read more about COSIRA II Symposium: Angina: The Scope of the Challenge \">Watch Video<i aria-hidden=\"true\" class=\"fa-sharp fa-arrow-right fa-light\"><\/i><\/a>\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/li>\n\t\t\t\t\t\t\t<li class=\"card content-3-or-4-up-card three-cards\" role=\"listitem\">\n\t\t\t\t\t\t\t\t\t\t\t<div class=\"card-image\">\n\t\t\t\t\t\t\t<img decoding=\"async\" data-src=\"https:\/\/shockwavemedical.com\/wp-content\/uploads\/2024\/11\/reducer-future.jpg\"\n\t\t\t\t\t\t\t\talt=\"youtube thumbnail screenshot of presenter speaking at TCT\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" class=\"lazyload\" style=\"--smush-placeholder-width: 1280px; --smush-placeholder-aspect-ratio: 1280\/720;\" \/>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\n\t\t\t\t\t<!-- Card Content -->\n\t\t\t\t\t<div class=\"card-heading-description-link\">\n\t\t\t\t\t\t<h3 class=\"card-heading\">COSIRA II Symposium: The Future of Clinical Data for the Reducer <\/h3>\n\n\t\t\t\t\t\t<div class=\"card-description-link\">\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\n<a data-atom=\"button\" class=\"card-link btn--tertiary\" href=\"https:\/\/shockwavemedical.com\/en-eu\/education\/cosira-ii-symposium-the-future-of-clinical-data-for-the-reducer\/\" target=\"_self\" aria-label=\"Read more about COSIRA II Symposium: The Future of Clinical Data for the Reducer \">Watch Video<i aria-hidden=\"true\" class=\"fa-sharp fa-arrow-right fa-light\"><\/i><\/a>\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/li>\n\t\t\t\t\t<\/ul>\n\t<\/div>\n<\/section>\n\n\n<section id=\"block_7889c86550e9ce996acd830c39606d7f\" class=\"block block--wysiwyg wysiwyg_styles u-bgColorNone container\">\n\t<div class=\"u-wysiwyg u-animation\">\n\t\t<p><span class=\"legal_copy\">The physicians featured are paid consultants for Shockwave Medical.<\/span><\/p>\n\t<\/div>\n\t<\/section>\n\n<section\n\tid=\"block_30a20d7dd1596eeb3e5d2d1da644d538\"\n\tclass=\"block block--spacer-with-optional-divider \"\n\taria-label=\"Spacer section with optional divider\">\n\t<div class=\"spacer-with-optional-divider-container container\">\n\n\t\t<!-- Space Above -->\n\t\t<div\n\t\t\tclass=\"space-above\"\n\t\t\tstyle=\"--aboveDesktop: 60px; --aboveMobile: 30px;\"\n\t\t\taria-hidden=\"true\"\n\t\t\trole=\"presentation\">\n\t\t<\/div>\n\n\t\t<!-- Optional Divider -->\n\t\t\n\t\t<!-- Space Below -->\n\t\t<div\n\t\t\tclass=\"space-below\"\n\t\t\tstyle=\"--belowDesktop: 0px; --belowMobile: 0px;\"\n\t\t\taria-hidden=\"true\"\n\t\t\trole=\"presentation\">\n\t\t<\/div>\n\n\t<\/div>\n<\/section>\n\n\n<section id=\"resources\" class=\"block block--resource-list text_colors \">\n\t<div class=\"block__container\">\n\t\t<div class=\"container-inner\">\n\t\t\t\t\t\t\t<h3 id=\"resources-heading\" class=\"heading\">\n\t\t\t\t\tResources\t\t\t\t<\/h3>\n\t\t\t\n\t\t\t\t\t\t\t<ul class=\"resource-list--links-container\" role=\"list\" aria-label=\"Resource links\" style=\"--column-count: 3;\">\n\t\t\t\t\t\t\t\t\t\t\t<li class=\"resource-list--link\" role=\"listitem\">\n\t\t\t\t\t\t\t\n<a data-atom=\"button\" class=\"btn--line\" href=\"https:\/\/shockwavemedical.com\/wp-content\/uploads\/2024\/11\/Shockwave-Reducer-Spec-Sheet.pdf\" target=\"_blank\" aria-label=\"Shockwave Reducer Product Spec Sheet - download asset\" download><span class=\"text-content\">Shockwave Reducer Product Spec Sheet<\/span><i aria-hidden=\"true\" class=\"fa-arrow-down-to-bracket fa-light\"><\/i><\/a>\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t\t\t\t<li class=\"resource-list--link\" role=\"listitem\">\n\t\t\t\t\t\t\t\n<a data-atom=\"button\" class=\"btn--line\" href=\"https:\/\/ifu.sw-reducer.com\/\" target=\"_blank\" aria-label=\"Shockwave Reducer Instructions for Use - opens in a new tab\" rel=\"noopener\"><span class=\"text-content\">Shockwave Reducer Instructions for Use<\/span><i aria-hidden=\"true\" class=\"fa-sharp fa-arrow-right fa-light\"><\/i><\/a>\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t\t\t\t<li class=\"resource-list--link\" role=\"listitem\">\n\t\t\t\t\t\t\t\n<a data-atom=\"button\" class=\"btn--line\" href=\"https:\/\/shockwavemedical.com\/wp-content\/uploads\/2024\/11\/Shockwave-Reducer-Physician-Brochure.pdf\" target=\"_blank\" aria-label=\"Shockwave Reducer Brochure - download asset\" download><span class=\"text-content\">Shockwave Reducer Brochure<\/span><i aria-hidden=\"true\" class=\"fa-arrow-down-to-bracket fa-light\"><\/i><\/a>\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t\t<\/ul>\n\t\t\t\t\t<\/div>\n\t<\/div>\n<\/section>\n\n<section\n\tid=\"block_30a20d7dd1596eeb3e5d2d1da644d538\"\n\tclass=\"block block--spacer-with-optional-divider \"\n\taria-label=\"Spacer section with optional divider\">\n\t<div class=\"spacer-with-optional-divider-container container\">\n\n\t\t<!-- Space Above -->\n\t\t<div\n\t\t\tclass=\"space-above\"\n\t\t\tstyle=\"--aboveDesktop: 60px; --aboveMobile: 30px;\"\n\t\t\taria-hidden=\"true\"\n\t\t\trole=\"presentation\">\n\t\t<\/div>\n\n\t\t<!-- Optional Divider -->\n\t\t\n\t\t<!-- Space Below -->\n\t\t<div\n\t\t\tclass=\"space-below\"\n\t\t\tstyle=\"--belowDesktop: 0px; --belowMobile: 0px;\"\n\t\t\taria-hidden=\"true\"\n\t\t\trole=\"presentation\">\n\t\t<\/div>\n\n\t<\/div>\n<\/section>\n\n\n<section id=\"block_8b73f02765adbfde6733444a3e844f3d\" class=\"block block--wysiwyg wysiwyg_styles u-bgColorNone shockwave container\">\n\t<div class=\"u-wysiwyg u-animation\">\n\t\t<hr \/>\n<p><span class=\"legal_copy\">*Shockwave Reducer is commercially available in select European countries and has been implanted in over 3,500 patients. It is currently under clinical investigation in the U.S. <\/span><\/p>\n<p><span class=\"legal_copy\"><strong>Caution:<\/strong> In the United States, Shockwave Reducer is an investigational device, limited by United States law to investigational use. The Reducer is subject of Investigational testing and is being studied in the COSIRA-II trial in Canada. <\/span><\/p>\n<p><span class=\"legal_copy\">Shockwave Reducer is commercially available in certain countries outside the U.S. and Canada. Please contact your local representative for specific country availability. Prior to use, please reference the Instructions for Use for more information on warnings, precautions and adverse events: <a href=\"https:\/\/ifu.sw-reducer.com\/\" target=\"_blank\" rel=\"noopener\">ifu.sw-reducer.com<\/a><\/span><\/p>\n<p><span class=\"legal_copy\">1: Abdallah, M. J Am Coll Cardiol 2017;69:2039-50.<br \/>\n2: Stone, G. 2-year results from the ABSORB IV randomized trial. TCT 2019.<br \/>\n3: Patel, M. N Engl J Med 2010; 362:886-895.<br \/>\n4: Samuels, B. J Am Coll Cardiol 2023; 82:1245-1263.<br \/>\n5: Verheye S, et al. Coronary sinus narrowing for the treatment of refractory angina: one-year results of the REDUCER-I study. EuroIntervention. 2025 Aug 4;21(15):e879-e881.<br \/>\n6: Verheye et al. Coronary Sinus Narrowing for Treating Refractory Angina. REDUCER-I Multicenter \u201cReal-World\u201d Observational Study Primary Endpoint Analysis. JACC Cardiovasc Interv. 2024;17:2908-18.<br \/>\n7: de Silva, R, van de Hoef, T, van Kuijk, J. et al. Coronary Sinus Reduction for REDUCER-I Patients With Refractory Angina and Angiographically Nonobstructive Coronary Artery Disease. JACC Adv. 2026 Apr, 5 (4).<br \/>\n8: de Silva, R. Presented at ESC 2025.<br \/>\n9: Verheye, S. Presented at TCT 2025.<br \/>\n10: Foley et al. The Lancet. 2024 Apr 8; https:\/\/doi.org\/10.1016\/S0140-6736(24)00256-3.<br \/>\n11: Verheye S, Jolicoeur EM, Behan MW, et al. Efficacy of a device to narrow the coronary sinus in refractory angina. N Engl J Med 2015; 372: 519-527.<\/span><\/p>\n\t<\/div>\n\t<\/section>\n\n<section\n\tid=\"block_30a20d7dd1596eeb3e5d2d1da644d538\"\n\tclass=\"block block--spacer-with-optional-divider \"\n\taria-label=\"Spacer section with optional divider\">\n\t<div class=\"spacer-with-optional-divider-container container\">\n\n\t\t<!-- Space Above -->\n\t\t<div\n\t\t\tclass=\"space-above\"\n\t\t\tstyle=\"--aboveDesktop: 60px; --aboveMobile: 30px;\"\n\t\t\taria-hidden=\"true\"\n\t\t\trole=\"presentation\">\n\t\t<\/div>\n\n\t\t<!-- Optional Divider -->\n\t\t\n\t\t<!-- Space Below -->\n\t\t<div\n\t\t\tclass=\"space-below\"\n\t\t\tstyle=\"--belowDesktop: 0px; --belowMobile: 0px;\"\n\t\t\taria-hidden=\"true\"\n\t\t\trole=\"presentation\">\n\t\t<\/div>\n\n\t<\/div>\n<\/section>","protected":false},"excerpt":{"rendered":"<p>Shockwave Reducer is designed to treat the symptoms of refractory angina through a permanent, controlled narrowing of the coronary sinus.<\/p>\n","protected":false},"author":15,"featured_media":4044,"parent":9780,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"content-type":"","footnotes":""},"class_list":["post-4679","page","type-page","status-publish","has-post-thumbnail","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/shockwavemedical.com\/en-eu\/wp-json\/wp\/v2\/pages\/4679","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/shockwavemedical.com\/en-eu\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/shockwavemedical.com\/en-eu\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/shockwavemedical.com\/en-eu\/wp-json\/wp\/v2\/users\/15"}],"replies":[{"embeddable":true,"href":"https:\/\/shockwavemedical.com\/en-eu\/wp-json\/wp\/v2\/comments?post=4679"}],"version-history":[{"count":3,"href":"https:\/\/shockwavemedical.com\/en-eu\/wp-json\/wp\/v2\/pages\/4679\/revisions"}],"predecessor-version":[{"id":14719,"href":"https:\/\/shockwavemedical.com\/en-eu\/wp-json\/wp\/v2\/pages\/4679\/revisions\/14719"}],"up":[{"embeddable":true,"href":"https:\/\/shockwavemedical.com\/en-eu\/wp-json\/wp\/v2\/pages\/9780"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/shockwavemedical.com\/en-eu\/wp-json\/wp\/v2\/media\/4044"}],"wp:attachment":[{"href":"https:\/\/shockwavemedical.com\/en-eu\/wp-json\/wp\/v2\/media?parent=4679"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}