Head-to-Head ROLLING-STONE Registry Showcases Safety of IVL over Atherectomy
The ROLLING-STONE Registry is the largest, prospective, multi-center registry with a head-to-head comparison after propensity score matching (PSM) of Shockwave Intravascular Lithotripsy (IVL) versus rotational atherectomy (AT) in a real-world, all-comers population. The 1,005 patient registry compared the procedural success, intraprocedural complications and 30 day and 1 year MACE rates after PSM of IVL versus rotational atherectomy (RA) and orbital atherectomy (OA).
In this interview, we sat down with the lead investigator of the registry, Dr. Enrico Cerrato, San Luigi Gonzaga University Hospital and Rivoli Hospital, Italy, to discuss the outcomes of the ROLLING-STONE Registry and how he anticipates the results may impact the daily practice of interventional cardiologists.
Download the summary and watch our interview with Dr. Enrico Cerrato to learn more about the trial and to hear his perspective.
- Trial design: Prospective, multi-center, double-arm, all-comers study of 1,005 patients with moderate-severe calcification treated with atherectomy or IVL from 23 Italian institutions
- Safety endpoints: Freedom from MACE at 30 days and one year after PSM and inverse probability weighting (IPW) (core-lab adjudicated)
- Primary efficacy endpoint: Procedural success: stent delivery with residual stenosis <30% and absence of in-hospital MACE (core-lab adjudicated)
IVL demonstrates a favorable 30-day MACE and statistically significant lower 1-year MACE after PSM as compared to atherectomy
IVL demonstrates similar procedural success with favorable intraprocedural complications as compared to atherectomy
Cerrato, E. (2025, March). Intravascular Lithotripsy And/Or Mechanical Debulking Multicenter Registry For The Treatment Of Complex Calcified Coronary Arteries: Rolling Stone Registry. Cardiovascular Research Technologies (CRT) 2025.
