DISRUPT CAD Pooled OCT Subgroup Analysis

Explore the OCT sub-analysis of individual patient data pooled from four coronary studies to see Shockwave Intravascular Lithotripsy (IVL) outcomes, fracture analysis and stent expansion predictors across various calcium arcs and nodule presence.

DISRUPT CAD POOLED OCT Analysis logo
DISRUPT CAD Pooled OCT Subgroup analysis logo

DISRUPT CAD Pooled OCT Analysis Conclusions

  • The present individual patient data pooled analysis of four studies (N=262) represents the largest evaluation of Shockwave IVL by OCT 
  • OCT demonstrated extensive calcium fracture after Shockwave IVL treatment with excellent stent expansion of severely calcified lesions 
  • Visible calcium fracture and calcium characteristics were not predictors of stent expansion following treatment with Shockwave IVL 

Moderated Poster, TCT 120: OCT Characterization of Shockwave IVL for Treatment of Calcified Coronary Lesions: Patient-level Pooled Analysis of the DISRUPT CAD OCT Sub-studies, Ziad A. Ali, TCT 2021. 

DISRUPT CAD I DISRUPT CAD II DISRUPT CAD III DISRUPT CAD IV DISRUPT CAD Pooled
Enrollment Dec 2015 – Sep 2016  May 2018 – Mar 2019  Jan 2019 – Mar 2020  Nov 2019 – Apr 2020 Dec 2015 – Apr 2020 
Study Design Prospective, multi-arm, single-arm
ITT (N) 601 1203  3844 645 6286
OCT Analysis* 282 57 106* 71* 262
OCT Core Laboratory Cardiovascular Research Foundation, New York, NY 
Target Lesions Severely calcified**, de novo coronary artery lesions 

*Patient enrollment in OCT sub-studies was open to all sites participating in the DISRUPT CAD studies that routinely perform OCT imaging.
** Includes patients from DISRUPT CAD III and IV. 

1: Brinton et al. Circulation 2019;139:834-836
2: Ali et al. J Am Coll Cardiol Img 2017;10:897-906
3: Ali et al. Circ Cardiovasc Interv 2019;12:e008434
4: Hill et al. J Am Coll Cardiol 2020;76:2635-46
5: Saito et al. Circ J 2021;85(6):826-33
6:Kereiakes et al., J Am Coll Cardiol Intv 2021;14:1337-48

Accordion Section

Review the full CAD Pooled OCT presentation

See All Clinical Evidence
See All Clinical Evidence
  • DISRUPT CAD I
    Single-arm, pre-market study demonstrating the safety and performance of Shockwave IVL in heavily calcified coronary lesions.
    Coronary IVL
  • DISRUPT CAD II
    European post-market study confirming DISRUPT CAD I results and showing strong safety and procedural success with Shockwave coronary IVL.
    Coronary IVL
  • DISRUPT CAD III
    Largest and most rigorous Shockwave study showcasing safety, effectiveness and ease of use of Shockwave coronary IVL. 
    Coronary IVL