Key Findings

  • CAD pooled is the largest systematic assessment of coronary IVL to-date based on individual patient data from the Disrupt CAD I-IV clinical program.
  • Coronary IVL achieved high procedural success in one of the most severe and longest calcified vessel segments reported for any PCI trial to date. IVL delivered largely via transradial approach. ​
  • Coronary IVL was safe with low rates of MACE and very low rates of severe angiographic complications in these complex target lesions across multiple trials, centers and patient subgroups.​
  • Coronary IVL was consistently effective in achieving high acute gain and low residual stenosis across multiple trials, centers and patient subgroups. ​

Cad Pooled By the Numbers

procedural angiographic outcomes post stent procedural angiographic outcomes post stent

* Procedural angiographic outcomes post stent.

Learn More About Outcomes From the Largest Evaluation of IVL

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OCT SUBGROUP ANALYSIS

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Sex Subgroup Analysis

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Pooled Analysis Study Design

  • Individual patient-data (IPD) pooled analysis of the Disrupt CAD I-IV studies
  • Uniform study criteria, endpoints, adjudication, follow-up
  • Multivariate analysis: Predictors of MACE and procedural success
  • Safety and effectiveness sub-group analysis
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IVL has Very Low Rates of Angiographic Complications Despite Lesion Complexity

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IVL has Low Rates of MACE, Mostly Driven By In-Hospital Non‑Q‑Wave MI

in-hospital and 30-day mace bar graph in-hospital and 30-day mace bar graph

*Per protocol: CK-MB level >3x ULN at discharge (peri-procedural MI): 97% of NQWMI occurred prior to discharge

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