DISRUPT CAD Pooled | Shockwave Medical

CAD pooled is the largest systematic assessment of coronary IVL to-date based on individual patient data from the Disrupt CAD I-IV clinical program.
Coronary IVL achieved high procedural success in one of the most severe and longest calcified vessel segments reported for any PCI trial to date. IVL delivered largely via transradial approach.
Coronary IVL was safe with low rates of MACE and very low rates of severe angiographic complications in these complex target lesions across multiple trials, centers and patient subgroups.
Coronary IVL was consistently effective in achieving high acute gain and low residual stenosis across multiple trials, centers and patient subgroups.

procedural angiographic outcomes post stent

procedural angiographic outcomes post stent

* Procedural angiographic outcomes post stent.

OCT SUBGROUP ANALYSIS

Sex Subgroup Analysis

Individual patient-data (IPD) pooled analysis of the Disrupt CAD I-IV studies
Uniform study criteria, endpoints, adjudication, follow-up
Multivariate analysis: Predictors of MACE and procedural success
Safety and effectiveness sub-group analysis

cad i-iv itt population

cad i-iv itt population

angiographic complications chart

angiographic complications chart

in-hospital and 30-day mace bar graph

in-hospital and 30-day mace bar graph

*Per protocol: CK-MB level >3x ULN at discharge (peri-procedural MI): 97% of NQWMI occurred prior to discharge

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