The individual patient data pooled analysis of 4 studies (N=262) represents the largest evaluation of IVL by OCT

Consistent OCT core laboratory evaluation across all Disrupt CAD clinical programs

cad studies table cad studies table

* Patient enrollment in OCT sub-studies was open to all sites participating in the Disrupt CAD studies that routinely perform OCT imaging.
† Includes patients from the roll-in cohort.

 

1 Brinton et al. Circulation 2019;139:834-836
2 Ali et al. J Am Coll Cardiol Img 2017;10:897-906
3 Ali et al. Circ Cardiovasc Interv 2019;12:e008434
4 Hill et al. J Am Coll Cardiol 2020;76:2635-46
5 Saito et al. Circ J 2021;85(6):826-33
6 Kereiakes et al., J Am Coll Cardiol Intv 2021;14:1337-48

IVL demonstrated Large MSAs & Stent Expansion demonstrated by OCT analysis in Concentric Calcium post-IVL and Stenting

OCT demonstrated analysis table OCT demonstrated analysis table mobile

Moderated Poster, TCT 120: OCT Characterization of Shockwave IVL for Treatment of Calcified Coronary Lesions:

Patient-level Pooled Analysis of the Disrupt CAD OCT Sub-studies, Ziad A. Ali, TCT 2021.

OCT Images demonstrated Extensive Calcium Fracture After IVL Treatment With Excellent Stent Expansion Of Severely Calcified Lesions

visible calcium chart visible calcium fracture analysis

Moderated Poster, TCT 120: OCT Characterization of Shockwave IVL for Treatment of Calcified Coronary Lesions: Patient-level Pooled Analysis of the Disrupt CAD OCT Sub-studies, Ziad A. Ali, TCT 2021.

OCT May Not Detect Microfractures in Calcific Plaque That Increases Vessel Compliance

MicroCT Allows for Microfracture Visualization Post-IVL

pre and post-ivl images pre and post-ivl images

Moderated Poster, TCT 163: OCT Characterization of Eccentric Versus Concentric Calcium Treated With Shockwave IVL: Patient-level Pooled Analysis of the Disrupt CAD OCT Sub-studies. Ziad A. Ali, TCT 2021

Conclusions from Pooled OCT Analysis

  • The present individual patient data pooled analysis of 4 studies (N=262) represents the largest evaluation of IVL by OCT
  • OCT demonstrated extensive calcium fracture after IVL treatment with excellent stent expansion of severely calcified lesions
  • Visible calcium fracture and calcium characteristics were not predictors of stent expansion following treatment with IVL

Moderated Poster, TCT 120: OCT Characterization of Shockwave IVL for Treatment of Calcified Coronary Lesions: Patient-level Pooled Analysis of the Disrupt CAD OCT Sub-studies, Ziad A. Ali, TCT 2021.

Review the Full CAD Pooled OCT Presentation

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