Breaking the Calcium Code: Understanding Shockwave IVL Mechanism of Action across Multiple Calcium Morphologies
Join Dr. Ziad Ali, Dr. Jai Khatri, Dr. Aloke Finn and Professor James Spratt as they discuss coronary artery calcification and the importance of understanding calcium morphologies in guiding treatment during percutaneous coronary intervention (PCI).
During the webinar, the Faculty review data from a recent cadaver-based comparative study that evaluated Intravascular Lithotripsy (IVL) alongside cutting balloons and ultra–high-pressure balloons using micro-CT, OCT, and histology. The study included calcium modification data from key calcium types—concentric, eccentric, and nodular calcium —and they explain why accurate assessment of calcium morphology is essential for selecting safe and effective treatment options. Findings from the study demonstrated that IVL consistently produces calcium fractures in most lesions, while minimizing vessel wall injury, whereas high-pressure balloons frequently damaged the vessel wall with less consistent fracture. An important consideration given the association between medial injury and adverse long-term outcomes.
Additionally, the Faculty also discuss Shockwave IVL’s mechanism of action, highlighting how ultrasonic pressure waves selectively fracture calcium based on acoustic impedance while preserving soft tissue. Clinical case examples illustrate the role of IVL in complex and high-risk lesions where procedural safety is critical, reinforcing IVL’s value as a low-risk and effective approach to calcium modification across a range of coronary anatomies.
Drs. Ali, Khatri, and Finn, and Professor Spratt are paid consultants of Shockwave Medical. Views expressed are those of the presenters and not necessarily those of Shockwave IVL.
Shockwave IVL: In the U.S.: Rx only. Prior to use, please reference the Important Safety Information for more information on indications, contraindications, warnings, precautions and adverse events. Please contact your local Shockwave representative for specific country availability.
